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Nucleic Acids In Innate Immunity

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Nucleic Acids In Innate Immunity

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Author : Ken J. Ishii
language : en
Publisher: CRC Press
Release Date : 2008-05-22

Nucleic Acids In Innate Immunity written by Ken J. Ishii and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-22 with Medical categories.

Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation

Molecular Biology Of Rna

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Author : David Elliott
language : en
Publisher: Oxford University Press
Release Date : 2017-01-31

Molecular Biology Of Rna written by David Elliott and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-31 with Science categories.

RNA plays a central, and until recently, somewhat underestimated role in the genetics underlying all forms of life on earth. This versatile molecule not only plays a crucial part in the synthesis of proteins from a DNA template, but is also intrinsically involved in the regulation of gene expression, and can even act as a catalyst in the form of a ribozyme. This latter property has led to the hypothesis that RNA - rather than DNA - could have played an essential part in the origin of life itself. This landmark text provides a systematic overview of the exciting and rapidly moving field of RNA biology. Key pioneering experiments, which provided the underlying evidence for what we now know, are described throughout, while the relevance of the subject to human disease is highlighted via frequent boxes. For the second edition of Molecular Biology of RNA, more introductory material has been incorporated at the beginning of the text, to aid students studying the subject for the first time. Throughout the text, new material has been included - particularly in relation to RNA binding domains, non-coding RNAs, and the connection between RNA biology and epigenetics. Finally, a new closing chapter discusses how exciting new technologies are being used to explore current topical areas of research.

Crispr Cas Systems

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Author : Rodolphe Barrangou
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-13

Crispr Cas Systems written by Rodolphe Barrangou and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-13 with Science categories.

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

Dna Repair Machinery In Innate And Adaptive Immunity

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Author : Feilong Meng
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-01

Dna Repair Machinery In Innate And Adaptive Immunity written by Feilong Meng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-01 with Science categories.

Nucleic Acid Sensors And Antiviral Immunity

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Author : Dr. Prakash Sambhara
language : en
Publisher: CRC Press
Release Date : 2012-11-26

Nucleic Acid Sensors And Antiviral Immunity written by Dr. Prakash Sambhara and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-26 with Science categories.

The discovery of Toll-like receptors (TLRs) in the late 1990s ushered in a new age of discovery for innate immunity. The importance of TLRs for immunology and biomedical research was recognized with the Nobel Prize for Medicine or Physiology in 2011. The prize was shared by three scientists: Ralph Steinman (for the discovery of dendritic cells, whi

Innate Immunity In Health And Disease

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Author : Shailendra K. Saxena
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-08-25

Innate Immunity In Health And Disease written by Shailendra K. Saxena and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-25 with Medical categories.

The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.

Structural Immunology Of Molecular Innate Immunity

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Author : Hyun Ho Park
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-31

Structural Immunology Of Molecular Innate Immunity written by Hyun Ho Park and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-31 with Medical categories.

Innate immunity has a critical role in the early stage of the host defense response by the timely recognition of pathogenic or danger signals by various cell surface or cytoplasmic receptors. This is followed by signal transduction via various adaptor and effector molecules. The main functions of innate immunity are to identify and remove the invading pathogens, to recruit various immune cells to the site of infection, and to prepare the adaptive immune response. The Innate immune system has been intensively studied for several decades and now we can begin to understand this system on a molecular level.

Self And Nonself

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Author : Carlos López-Larrea
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-03-07

Self And Nonself written by Carlos López-Larrea and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-07 with Medical categories.

In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.

Nucleic Acid Sensors And Antiviral Immunity

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Author : Dr. Prakash Sambhara
language : en
Publisher: CRC Press
Release Date : 2012-11-26

Evolutionary Concepts In Immunology

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Author : Robert Jack
language : en
Publisher: Springer
Release Date : 2019-06-13

Evolutionary Concepts In Immunology written by Robert Jack and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-13 with Medical categories.

Immunology is a nodal subject that links many areas of biology. It permeates the biosciences, and also plays crucial roles in diagnosis and therapy in areas of clinical medicine ranging from the control of infectious and autoimmune diseases to tumour therapy. Monoclonal antibodies and small molecule modulators of immunity are major factors in the pharmaceutical industry and now constitute a multi billion dollar business. Students in these diverse areas are frequently daunted by the complexity of immunology and the astonishing array of unusual mechanisms that go to make it up. Starting from Dobzhansky’s famous slogan, “Nothing in biology makes sense except in the light of evolution”, this book will serve to illuminate how evolutionary forces shaped immunity and thus provide an explanation for how many of its counter intuitive oddities arose. By doing so it will provide a conceptual framework on which students may organise the rapidly growing flood of immunological knowledge.

Nucleic Acids In Innate Immunity

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