Nucleic Acid Sensors And Antiviral Immunity

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Nucleic Acid Sensors And Antiviral Immunity

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Author : Dr. Prakash Sambhara
language : en
Publisher: CRC Press
Release Date : 2012-11-26

Nucleic Acid Sensors And Antiviral Immunity written by Dr. Prakash Sambhara and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-26 with Science categories.

The discovery of Toll-like receptors (TLRs) in the late 1990s ushered in a new age of discovery for innate immunity. The importance of TLRs for immunology and biomedical research was recognized with the Nobel Prize for Medicine or Physiology in 2011. The prize was shared by three scientists: Ralph Steinman (for the discovery of dendritic cells, whi

Nucleic Acid Sensors And Antiviral Immunity

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Author : Dr. Prakash Sambhara
language : en
Publisher: CRC Press
Release Date : 2012-11-26

Nucleic Acid Sensors And Antiviral Immunity written by Dr. Prakash Sambhara and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-26 with Science categories.

The discovery of Toll-like receptors (TLRs) in the late 1990s ushered in a new age of discovery for innate immunity. The importance of TLRs for immunology and biomedical research was recognized with the Nobel Prize for Medicine or Physiology in 2011. The prize was shared by three scientists: Ralph Steinman (for the discovery of dendritic cells, whi

Nucleic Acid Sensors And Antiviral Immunity

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Author : . Prakash Sambhara
language : en
Publisher: CRC Press
Release Date : 2019-12-02

Nucleic Acid Sensors And Antiviral Immunity written by . Prakash Sambhara and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-02 with categories.

The discovery of Toll-like receptors (TLRs) in the late 1990s ushered in a new age of discovery for innate immunity. The importance of TLRs for immunology and biomedical research was recognized with the Nobel Prize for Medicine or Physiology in 2011. The prize was shared by three scientists: Ralph Steinman (for the discovery of dendritic cells, which express TLRs and whose activation by them provides a link between innate and adaptive immunity), Jules Hoffman (who made the pioneering observation of Toll in fruit fly anti-fungal immunity) and Bruce Beutler (who uncovered the role of TLR4 in the response to LPS). Work on TLRs inspired many researchers, and led to a search for other receptors in innate immunity. There are now several additional families of such receptors known, notably RIG-I-like receptors (RLRs), C-type lectin receptors (CLRs) and AIM2-like receptors (ALRs). A notable feature is the detection of nucleic acids from pathogens, but also from host cells in certain contexts, particularly in autoimmune diseases. Nucleic Acid Sensors and Antiviral Immunity presents a timely and extensive account of the detection of nucleic acids in infection and inflammation. We have chapters by Beutler, Hoffman and Shizuo Akira, who is the most cited immunologist of the past ten years, for his work on innate immunity, which gives us an indication of the importance of the field. Several other pioneers in the field present comprehensive and highly lucid up-to-date accounts of their particular interests, revealing the large amount of activity in the past few years, as the literature continues to grow and become ever more complex. The fly yet again provides new insights, and anti-viral mechanisms in this key model organism are described. Other topics include the ability of viruses such as poxviruses, hepatitis C virus and HIV to interfere with detection and signalling; new insights into signalling including subcellular localization of signalling proteins, complex regulation o

Nucleic Acid Sensing And Immunity Part B

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Author :
language : en
Publisher: Academic Press
Release Date : 2019-03-21

Nucleic Acid Sensing And Immunity Part B written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-21 with Science categories.

Nucleic Acid Sensing and Immunity - PART B, Volume 345 gives a comprehensive overview of the nucleic acid machinery, from plants to mammalians, along with their regulation. Chapters in this updated volume include Nucleic acids sensing in allergic disorders, Nucleic acids sensing in autoimmune disorders, Nucleic acid sensing in inflammatory disorders, Viral nucleic acid sensing inflammasomes in intestinal host defense, Genome damage sensing leads to tissue homeostasis in Drosophila, Nucleic acids sensing in plants, Nucleic Acid sensing in invertebrates, amongst other topics. - Provides an accurate, state-of-the-art resource on RNA sensing - Includes the work of a well-known tumor immunologist - Links intestinal host defense and viral nucleic acid sensing - Presents a chapter on the negative regulation of DNA sensing, a timely topic

Nucleic Acids In Innate Immunity

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Author : Ken J. Ishii
language : en
Publisher: CRC Press
Release Date : 2008-05-22

Nucleic Acids In Innate Immunity written by Ken J. Ishii and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-22 with Medical categories.

Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation

Molecular Biology Of Rna

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Author : David Elliott
language : en
Publisher: Oxford University Press
Release Date : 2017-01-31

Molecular Biology Of Rna written by David Elliott and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-31 with Science categories.

RNA plays a central, and until recently, somewhat underestimated role in the genetics underlying all forms of life on earth. This versatile molecule not only plays a crucial part in the synthesis of proteins from a DNA template, but is also intrinsically involved in the regulation of gene expression, and can even act as a catalyst in the form of a ribozyme. This latter property has led to the hypothesis that RNA - rather than DNA - could have played an essential part in the origin of life itself. This landmark text provides a systematic overview of the exciting and rapidly moving field of RNA biology. Key pioneering experiments, which provided the underlying evidence for what we now know, are described throughout, while the relevance of the subject to human disease is highlighted via frequent boxes. For the second edition of Molecular Biology of RNA, more introductory material has been incorporated at the beginning of the text, to aid students studying the subject for the first time. Throughout the text, new material has been included - particularly in relation to RNA binding domains, non-coding RNAs, and the connection between RNA biology and epigenetics. Finally, a new closing chapter discusses how exciting new technologies are being used to explore current topical areas of research.

Nucleic Acid Sensing And Immunity Part A

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Author :
language : en
Publisher: Academic Press
Release Date : 2019-02-22

Nucleic Acid Sensing And Immunity Part A written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-22 with Science categories.

Nucleic Acid Sensing and Immunity - PART A, Volume 344, provides a comprehensive overview of the nucleic acid machinery, from plants to mammalians, as well as their regulation. Specific chapters in this updated release include Molecular bases of discrimination between self from non-self nucleic acids, Intracellular RNA sensing in mammalian cells, Nuclear DNA damage and nucleic acid sensing, Negative regulation of nucleic acid sensing, Dendritic cell responses to exogenous nucleic acids, Activating the nucleic acid-sensing machinery for anticancer immunity, and Nucleic acid sensing and inflammasomes, amongst other topics. - Provides an accurate, state-of-the-art resource on RNA sensing - Includes the work of a well-known tumor immunologist - Links intestinal host defense and viral nucleic acid sensing - Presents a chapter on the negative regulation of DNA sensing, a timely topic

Sensing Dna In Antiviral Innate Immunity

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Author : Chunfu Zheng
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-08

Sensing Dna In Antiviral Innate Immunity written by Chunfu Zheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-08 with Medical categories.

Nucleic Acid Associated Inflammation

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Author : Nadine Laguette
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-30

Nucleic Acid Associated Inflammation written by Nadine Laguette and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-30 with Medical categories.

Structural Immunology

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Author : Tengchuan Jin
language : en
Publisher: Springer Nature
Release Date : 2019-10-18

Structural Immunology written by Tengchuan Jin and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-18 with Medical categories.

This book presents a comprehensive overview of important immune molecules and their structure-function relationships. The immune system is highly complex, consisting of a network of molecules, cells, tissues and organs, and the immune reaction is involved in various physiological as well as pathological processes, including development, self-tolerance, infection, immunity, and cancer. Numerous molecules participate in immune recognition, inhibition and activation, and these important immune molecules can be roughly divided into cell surface receptors, intracellular receptors and intracellular signaling molecules. The study of how these immune molecules function at molecular level has laid the foundation for understanding the immune system. The book provides researchers and students with the latest research advances concerning the structural biology of key immune molecules/pathways, and offers immunologists essential insights into how these immune molecules function.