Immunomodulation Of Pancreatic Islets

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Immunomodulation Of Pancreatic Islets

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Author : Lanza
language : en
Publisher: CRC-Press
Release Date : 1994

Immunomodulation Of Pancreatic Islets written by Lanza and has been published by CRC-Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.

Immunomodulation Of Pancreatic Islets

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Author : Lanza
language : en
Publisher: CRC-Press
Release Date : 1997-09-01

Immunomodulation Of Pancreatic Islets written by Lanza and has been published by CRC-Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-09-01 with Medical categories.

Pancreatic Islet Transplantation Immunomodulation Of Pancreatic Islets

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Author : Robert Paul Lanza
language : en
Publisher:
Release Date : 1994

Pancreatic Islet Transplantation Immunomodulation Of Pancreatic Islets written by Robert Paul Lanza and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Diabetes categories.

Procurement Of Pancreatic Islets

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Author :
language : en
Publisher: CRC-Press
Release Date : 1997-09-01

Procurement Of Pancreatic Islets written by and has been published by CRC-Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-09-01 with Medical categories.

Immune Modulation With Amniotic Epithelial Cells In Pancreatic Islet Transplantation

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Author : Khalid Qureshi
language : en
Publisher:
Release Date : 2012

Immune Modulation With Amniotic Epithelial Cells In Pancreatic Islet Transplantation written by Khalid Qureshi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.

Chronic systemic immunosuppression in pancreatic islet transplantation restricts its clinical application. This study aims to explore the potential of cell-mediated immune-modulation as an alternative to conventional immunosuppressive regimens; specifically investigating the innate immunosuppressive properties of human amniotic epithelial cells (AEC). Cell constructs composed of human islets and AEC (islet:AEC) were bio-engineered in rotational culture. Insulin secretory capacity and immuno-modulatory potential were characterised using appropriate in vitro assays. Fluorescence immunocytochemistry and multiplex arrays was used to identify putative mediators of the immunosuppressive response in isolated AEC monocultures. Islets and islet:AEC constructs demonstrated sustained, physiologically-appropriate insulin secretion. Resting peripheral blood mononuclear cells (PBMC) were activated on exposure to human islets but this response was significantly (p

Immunoisolation Of Pancreatic Islets

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Author : Lanza
language : en
Publisher: CRC-Press
Release Date : 1994

Immunoisolation Of Pancreatic Islets written by Lanza and has been published by CRC-Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.

Immunomodulatory Biomaterials

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Author : Stephen F. Badylak
language : en
Publisher: Woodhead Publishing
Release Date : 2021-07-30

Immunomodulatory Biomaterials written by Stephen F. Badylak and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-30 with Medical categories.

Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an “inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response Provides a single reference for understanding and utilizing the host response in biomaterials design An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Mesenchymal Stem Cells And Immunomodulation

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Author : Charles J. Malemud
language : en
Publisher: Springer
Release Date : 2018-07-13

Mesenchymal Stem Cells And Immunomodulation written by Charles J. Malemud and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-13 with Science categories.

This essential volume explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to discover methods of suppressing the causal inflammatory response. It also further defines the methodologies required to develop research on MSCs in vitro into established preclinical animal models including those which are proven replicas of autoimmunity and pre-term labor, to name but two. Mesenchymal Stem Cells and Immunomodulation, part of Springer’s Stem Cell Biology and Regenerative Medicine, is an invaluable resource for researchers and clinicians working with stem cells, autoimmune disease, oncology, and reproductive medicine.

Xenotransplantation

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Author : David K.C. Cooper
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Xenotransplantation written by David K.C. Cooper and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

This is a time ofexcitement and progress in the field ofxenotransplantation. The work described in this book traces the development of the science of cross-spe cies transplantation, summarizes the current state ofour knowledge, and focuses on approaches directed toward future clinical application. The important question is not whether xenotransplantation will succeed, but rather how and under what circumstances xenografts will provide predictable enough results to warrant clinical application. The fact that the best results to date in clinical xenografting were achieved over three decades ago should not be a matter of discouragement, but rather a stimulus to apply new approaches to this area of work. The shortage of human organs for transplantation is cited frequently as the driving force behind the increased interest in xenotransplantation. This shortage is an undeniable fact, but there are additional potential advantages of xenotrans plantation, such as the ability to schedule replacement surgery on an elective basis and the modification of animals, organs, and tissues to improve acceptabil ity in the human host. The advances in the basic science ofxenotransplantation outlined in this book give hope that the immunologic barriers to xenotransplantation will be overcome and that transplanted organs and tissues will succeed consistently in humans. However, if our experience with human allografts provides an analogy, we may anticipate that clinical progress in xenografts will be plagued by failures and rewarded by successes, often without a complete understanding of the mechan isms involved.

Pancreatic Islet Biology

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Author : Anandwardhan A. Hardikar
language : en
Publisher: Springer
Release Date : 2016-10-25

Pancreatic Islet Biology written by Anandwardhan A. Hardikar and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-25 with Science categories.

This comprehensive volume discusses in vitro laboratory development of insulin-producing cells. It encompasses multiple aspects of islet biology—from embryonic development and stem cell differentiation to clinical studies in islet transplantation, regulation of islet beta-cell regeneration, pancreatic progenitors, mathematical modelling of islet development, epigenetic regulation, and much more. The chapter authors represent leading laboratories from around the world who contribute their international perspectives and global expertise. Collectively, they provide the reader with a concise yet detailed knowledge of processes and current developments in islet regenerative biology. Pancreatic Islet Biology, part of the Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers and clinicians in stem cells or endocrinology, especially those focusing on diabetes.