Immunophenotyping In Autoimmune Diseases And Cancer

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Immunophenotyping In Autoimmune Diseases And Cancer

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Author : Gábor J. Szebeni
language : en
Publisher: MDPI
Release Date : 2020-12-02

Immunophenotyping In Autoimmune Diseases And Cancer written by Gábor J. Szebeni and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-02 with Science categories.

The cooperation of highly specialized cell types maintains the homeostasis of multicellular organisms. The disturbance of that harmony contributes to the development of several diseases. Most of the cellular functions are executed by proteins, so it is essential to investigate biological processes at the protein level. Antibodies, complex biomolecules with high specificity, are used to recognize our protein of interest in a process known as “immunophenotyping”. One of the routinely used methods to study cellular proteins is flow cytometry, which detects cell surface or intracellular proteins at single-cell resolution. The other most frequent technique is the traditional immunohistochemical investigation of microscopic sections of human tissues. We called authors to publish their latest data studying cancer or autoimmune diseases by immunophenotyping.

Immunophenotyping In Autoimmune Diseases And Cancer

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Author : Gábor J. Szebeni
language : en
Publisher:
Release Date : 2020

Immunophenotyping In Autoimmune Diseases And Cancer written by Gábor J. Szebeni and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.

The cooperation of highly specialized cell types maintains the homeostasis of multicellular organisms. The disturbance of that harmony contributes to the development of several diseases. Most of the cellular functions are executed by proteins, so it is essential to investigate biological processes at the protein level. Antibodies, complex biomolecules with high specificity, are used to recognize our protein of interest in a process known as “immunophenotyping”. One of the routinely used methods to study cellular proteins is flow cytometry, which detects cell surface or intracellular proteins at single-cell resolution. The other most frequent technique is the traditional immunohistochemical investigation of microscopic sections of human tissues. We called authors to publish their latest data studying cancer or autoimmune diseases by immunophenotyping.

Emerging Concepts Targeting Immune Checkpoints In Cancer And Autoimmunity

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Author : Akihiko Yoshimura
language : en
Publisher: Springer
Release Date : 2017-11-25

Emerging Concepts Targeting Immune Checkpoints In Cancer And Autoimmunity written by Akihiko Yoshimura and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-25 with Medical categories.

This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.

Cancer And Autoimmunity

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Author : M.E. Gershwin
language : en
Publisher: Elsevier
Release Date : 2000-03-27

Cancer And Autoimmunity written by M.E. Gershwin and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-03-27 with Medical categories.

Of the two disciplines in parallel development for two decades, tumor immunology and transplantation immunology, the latter has thrived and has led to some of the most critical discoveries in immunobiology. The former continues to thwart both scientists and clinicians alike.The goal of immunologists in modern day research is to develop a simple and effective means to manipulate cancer in vivo, possibly encompassing several venues: identifying a phenotypic marker and the use of either active or passive immunization; include the use of passive reagents carrying "warheads" to selectively destroy cancer cells; or altering the basic process of cell survival.This excellent multidiscipline-authored volume presents a theme which has not been well described before. The papers include both basic and clinical science and range from sophisticated molecular biology to little more than phenomenology (e.g. the increased association of cancer in some autoimmune diseases and increased presentation of autoimmune phenomena in malignant condition). This, however, is state-of-the-art.This collection of themes will be of use not only to bench scientists, but also to clinicians who treat patients. The book represents progress at the cutting edge of this discipline, and points the way to further developments in the "black box" of immunology.

Modulating Cytokines As Treatment For Autoimmune Diseases And Cancer

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Author : Erwan Mortier
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-11

Modulating Cytokines As Treatment For Autoimmune Diseases And Cancer written by Erwan Mortier and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-11 with Medical categories.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Autoimmunity And Cancer

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Author : Soner Şahin
language : en
Publisher:
Release Date : 2022-08-25

Autoimmunity And Cancer written by Soner Şahin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-25 with categories.

The significance of autoimmune diseases increases day by day. Cancer is an important cause of mortality for which no definitive treatment has yet been found. Cancer can occur for many reasons. Studies have shown that autoimmunity underlies some types of cancer. On the contrary, antitumor immune responses may become cross-reactive with their own tissues, resulting in the development of autoimmunity. Further investigation of the relationship between autoimmunity and cancer will open new horizons for diagnosis and treatment of both groups of disease. This book presents studies of potential mechanisms linking autoimmunity and cancer and the relationship of malignancies with autoimmune disorders.

Holland Frei Cancer Medicine

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Author : Robert C. Bast, Jr.
language : en
Publisher: John Wiley & Sons
Release Date : 2017-03-10

Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-10 with Medical categories.

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Immunophenotyping

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Author : J Philip McCoy Jr
language : en
Publisher: Humana
Release Date : 2019-09-29

Immunophenotyping written by J Philip McCoy Jr and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-29 with Medical categories.

This volume presents the latest collection of immunophenotypic techniques and applications used in research and clinical settings. Chapters in this book cover topics such as constructions of high dimensions fluorescence and mass cytometry panels; fluorescence barcoding; using dried or lyophilized reagents; and immunophenotypic examples of specific cell types. The book concludes with a discussion on the critical roles of quality control and immunophenotyping in the clinical environment. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Immunophenotyping: Methods and Protocols is a valuable resource for any researchers, clinician, or scientist interested in learning more about this evolving field.

Cancer Immunotherapy Immuno Monitoring Mechanism Treatment Diagnosis And Emerging Tools

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Author : Chao Ma
language : en
Publisher: Frontiers E-books
Release Date : 2014-12-16

Cancer Immunotherapy Immuno Monitoring Mechanism Treatment Diagnosis And Emerging Tools written by Chao Ma and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-16 with Cancer categories.

In the past decade, significant progresses have taken place in the field of cancer immunotherapy. Tumor-targeting immunotherapies are being developed for most human cancers, including melanoma, prostate cancer, glioblastoma, sarcoma, lung carcinoma and hepatocellular carcinoma. The FDA has approved multiple molecular immunotherapeutics, such as Ipilimumab; cellular immunotherapies (e.g. adoptive cell transfer) are being tested in phase II/III clinical trials. Immunotherapetics has evolved into a sophisticated field: Multimodal therapeutic regimens are administrated to induce focused responses, curtail side- effects and improve therapeutic efficacy. The lack of effective clinical assessment tools remains a major challenge. Because of the intricacy of antitumor response, it is essential to scrutinize individual tumor-targeting immune cells and their functions at the finest details – molecules. In this regard, flow cytometry analysis modernized hematology and allows characterization of surface molecular signature on individual cells. More recently, microchip technologies and new variations of cytometry have enormously expanded the spectrum, throughout and multiplexity of single cell analysis. Nowadays, tens of millions of readouts can be generated through the course of a cancer immunotherapy to monitor the abundance, phenotype and a myriad of effector functions of single immune cells. At the same time, big data analytics and data mining methodologies have been adapted to achieve sensible diagnostic interpretations. Such a marriage of technology and analytics opens the door for informative point-of-care assessment of therapeutic efficacy and ensures timely therapeutic decisions. The new generation of personalized clinical diagnostics will revolutionize healthcare in the years to come.

Multiparameter Flow Cytometry In The Diagnosis Of Hematologic Malignancies

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Author : Anna Porwit
language : en
Publisher: Cambridge University Press
Release Date : 2018-01-25

Multiparameter Flow Cytometry In The Diagnosis Of Hematologic Malignancies written by Anna Porwit and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-25 with Medical categories.

This practical manual offers an active understanding of how to implement flow-cytometry when facing complex, haematological diseases.