Emerging Concepts Targeting Immune Checkpoints In Cancer And Autoimmunity
DOWNLOAD
Download Emerging Concepts Targeting Immune Checkpoints In Cancer And Autoimmunity PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Emerging Concepts Targeting Immune Checkpoints In Cancer And Autoimmunity book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Emerging Concepts Targeting Immune Checkpoints In Cancer And Autoimmunity
DOWNLOAD
Author : Akihiko Yoshimura
language : en
Publisher: Springer
Release Date : 2017-11-25
Emerging Concepts Targeting Immune Checkpoints In Cancer And Autoimmunity written by Akihiko Yoshimura and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-25 with Medical categories.
This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.
Immune Checkpoint Inhibitors
DOWNLOAD
Author : Afsheen Raza
language : en
Publisher: BoD – Books on Demand
Release Date : 2023-03-08
Immune Checkpoint Inhibitors written by Afsheen Raza and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-08 with Medical categories.
Immune Checkpoint Inhibitors - New Insights and Recent Progress explores a vast array of subjects related to immune checkpoint inhibitors and presents novel insights in this emerging field. Chapters address such topics as mechanistic approaches of emerging immune checkpoint inhibitors, their role in clinical and pre-clinical trials, the manipulation of the system by immune-related adverse events that hinder the utility of these immune molecules, and the predictive and prognostic aspects of these molecules as biomarkers of response in immunotherapy. The book is useful for students, clinicians, and scientists to gain updated information on managing patients treated with immune checkpoint inhibitors.
The Role Of Immune Checkpoint Molecules In Solid And Hematopoietic Stem Cell Transplantation
DOWNLOAD
Author : Vera Rebmann
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-07
The Role Of Immune Checkpoint Molecules In Solid And Hematopoietic Stem Cell Transplantation written by Vera Rebmann and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-07 with Medical categories.
Advancements In Immunology And Immunotherapy For Breast Cancer
DOWNLOAD
Author : Tomoharu Sugie
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-20
Advancements In Immunology And Immunotherapy For Breast Cancer written by Tomoharu Sugie and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-20 with Medical categories.
Combinational Immunotherapy Of Cancer Novel Targets Mechanisms And Strategies
DOWNLOAD
Author : Xuyao Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-15
Combinational Immunotherapy Of Cancer Novel Targets Mechanisms And Strategies written by Xuyao Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-15 with Medical categories.
Cancer immunotherapy, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has revolutionized the paradigm in cancer treatment. However, the clinical outcome of immunotherapy varies considerably among patients and only a minority of patients achieve long-term clinical benefits. This is largely attributed to the fact that existing cancer immunotherapies, which concentrate on several classical targets (CTAL-4, PD-1/PD-L1, etc.) and limited types of immune cell populations (T cells), are insufficient to cope with the complexity of highly heterogeneous tumor microenvironment (TME). This calls for more efforts to not only expand our toolbox for manipulating anticancer immunity but also diversify our combinational strategies. To this end, it is urgent to deeper our understanding of cancer immunotherapy by using both experimental and computational methodologies from multi-scale perspectives: 1) novel targets from either tumor cells or non-tumor cells within TME (e.g., tumor intrinsic resistance drivers, new immune checkpoints, neoantigens), 2) in-depth characterization of more immune cell populations (e.g., macrophages, Tregs, B cells) and their interactions and dynamics within TME, 3) landscape of actionable targets in patient populations for combination design. These efforts will open the avenue of rational design of combinational immunotherapies, allowing researchers and clinicians to design novel targeting therapeutics or to optimally orchestrate combinatory strategies aiming to surmount resistance mechanisms and improve clinical outcomes.
The Pituitary
DOWNLOAD
Author : Shlomo Melmed
language : en
Publisher: Academic Press
Release Date : 2022-05-20
The Pituitary written by Shlomo Melmed and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-20 with Medical categories.
The Pituitary, Fifth Edition continues the tradition of a cogent blend of basic science and clinical medicine. The comprehensive text written by expert pituitary scholars is devoted to the pathogenesis, diagnosis and treatment of pituitary disorders. The new fifth edition has been extensively revised to reflect the most recent data on new research advances in tumorigenesis and new therapeutic approaches for pituitary tumors, particularly in acromegaly and Cushing disease. Notably, new chapters devoted to the Pituitary-Immune Interface and Pituitary Radiotherapy have been included, along with a chapter on Aggressive Pituitary Adenomas developed to align with the WHOs Classification of Pituitary Tumors. Furthermore, new authors have been invited, ensuring a fresh perspective on critical issues in the field. This extensive body of knowledge is useful for students, trainees, physicians, and scientists who need to understand critical pituitary functions and how to care for patients with pituitary disorders. - Provides a detailed description of the wide spectrum of clinical disorders emanating from the dysfunction of the "master gland and the fundamental science underlying pituitary dysfunction - Brings together pituitary experts from all areas of research and practice who take readers all the way from bench research to genomic and proteomic analysis, clinical analysis, and new therapeutic approaches - Describes the mechanisms for disease pathogenesis, including both subcellular and extrinsic mechanisms that subserve normal and disordered pituitary hormone secretion and action
Lymphocyte Activation
DOWNLOAD
Author : L. E. Samelson
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1994
Lymphocyte Activation written by L. E. Samelson and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.
Williams Textbook Of Endocrinology E Book
DOWNLOAD
Author : Shlomo Melmed
language : en
Publisher: Elsevier Health Sciences
Release Date : 2024-04-03
Williams Textbook Of Endocrinology E Book written by Shlomo Melmed and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-03 with Medical categories.
**Selected for 2025 Doody's Core Titles® with "Essential Purchase" designation in Endocrinology/Metabolic Disease**Now fully revised and updated, Williams Textbook of Endocrinology, 15th Edition, remains your go-to reference for authoritative content on the full spectrum of adult and pediatric endocrine system disorders. World-renowned authors and editors expertly bridge the gap between basic science and clinical information, keeping you up to date with recent advances in medications, therapies, clinical trials, and more. This essential reference is a must-have resource for endocrinologists, endocrine surgeons, gynecologists, internists, pediatricians, and other clinicians who need current, comprehensive coverage of this multifaceted field. - Presents current information in a highly illustrated, user-friendly format for quick reference - Includes new chapters on Skeletal Regulation of Metabolism, Digitized Approaches to Diabetes Therapeutics, and MODY and Atypical Diabetes - Reflects updated approaches to transgender medicine as well as new coverage of viral infections, including COVID-19 - Covers hot topics such as personalized medicine; the latest methodologies and trends regarding cancer genomics, precision oncology, and cell biology; and updates in key areas such as adrenal dysfunction and diabetes - Provides state-of-the-art coverage of diabetes, metabolic syndrome, metabolic bone disorders, obesity and thyroid disease, as well as pituitary, gonadal, and adrenal disorders, and much more—all designed to help you provide optimal care to every patient - Features contributions from today's thought leaders in endocrinology - Contains a selected reading list and highlighted key references nominated by the editors
Emerging Concepts On The Nkg2d Receptor Nkg2d Ligand Axis In Health And Diseases
DOWNLOAD
Author : Nadia Guerra
language : en
Publisher: Frontiers Media SA
Release Date : 2020-05-22
Emerging Concepts On The Nkg2d Receptor Nkg2d Ligand Axis In Health And Diseases written by Nadia Guerra and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-22 with categories.
Rheumatology E Book
DOWNLOAD
Author : Marc C. Hochberg
language : en
Publisher: Elsevier Health Sciences
Release Date : 2022-07-29
Rheumatology E Book written by Marc C. Hochberg and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-29 with Medical categories.
Covering both the scientific basis of rheumatology and practical, clinical information for rheumatologists and trainees, Rheumatology, 8th Edition, remains a leading text in this fast-changing field. Dr. Marc Hochberg and his team of worldwide editors and authors keep you abreast of recent advances in the field— all in a user-friendly, accessible manner. Fully updated from cover to cover, this two-volume text is designed to meet the needs of all practicing and academic rheumatologists as well as arthritis-related health care professionals and scientists interested in rheumatic and musculoskeletal diseases. - Covers the epidemiology, pathogenesis, clinical manifestations, therapeutic approach, and management of all major as well as rarely encountered rheumatic and musculoskeletal diseases. - Discusses clinical examination, imaging principles, differential diagnosis, established and novel therapies, perioperative evaluation, pain management, basic science, and genetics of rheumatic and musculoskeletal diseases. - Uses a consistent, logical, reader-friendly format with templated chapters, concise text, and large-scale, state-of-the-art illustrations for efficient visual reference. - Contains new chapters covering pre-clinical disease and how to address these patients, common comorbidities in rheumatoid arthritis; emerging therapies for systemic sclerosis; immune mediated complications of checkpoint inhibitors; the epidemiology of COVID-19 and rheumatic and musculoskeletal diseases, emerging treatments for osteoarthritis, and big data analytics. - Provides updates to key topics such as systems biology and its impact on our understanding of the pathogenesis of rheumatic and musculoskeletal diseases, the microbiome in rheumatic musculoskeletal diseases, how to manage chronic pain in the patient with a rheumatic disease, drugs and reproductive health, and emerging therapies for patients with RA, SLE, spondyloarthritis, inflammatory muscle disease, and vasculitis. - Shares the knowledge and expertise of numerous new contributing authors, as well as new co-editor Dr. Désirée van der Heijde, who is an expert in psoriatic arthritis, spondyloarthritis, imaging, and clinical epidemiology. - Provides access to concise videos depicting the use of ultrasound for diagnosis and treatment. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. If you encounter issues with your eBook please contact Elsevier eBook+ support via [email protected].