Combinational Immunotherapy Of Cancer Novel Targets Mechanisms And Strategies
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Combinational Immunotherapy Of Cancer Novel Targets Mechanisms And Strategies
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Author : Xuyao Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-15
Combinational Immunotherapy Of Cancer Novel Targets Mechanisms And Strategies written by Xuyao Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-15 with Medical categories.
Cancer immunotherapy, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has revolutionized the paradigm in cancer treatment. However, the clinical outcome of immunotherapy varies considerably among patients and only a minority of patients achieve long-term clinical benefits. This is largely attributed to the fact that existing cancer immunotherapies, which concentrate on several classical targets (CTAL-4, PD-1/PD-L1, etc.) and limited types of immune cell populations (T cells), are insufficient to cope with the complexity of highly heterogeneous tumor microenvironment (TME). This calls for more efforts to not only expand our toolbox for manipulating anticancer immunity but also diversify our combinational strategies. To this end, it is urgent to deeper our understanding of cancer immunotherapy by using both experimental and computational methodologies from multi-scale perspectives: 1) novel targets from either tumor cells or non-tumor cells within TME (e.g., tumor intrinsic resistance drivers, new immune checkpoints, neoantigens), 2) in-depth characterization of more immune cell populations (e.g., macrophages, Tregs, B cells) and their interactions and dynamics within TME, 3) landscape of actionable targets in patient populations for combination design. These efforts will open the avenue of rational design of combinational immunotherapies, allowing researchers and clinicians to design novel targeting therapeutics or to optimally orchestrate combinatory strategies aiming to surmount resistance mechanisms and improve clinical outcomes.
Combinational Immunotherapy Of Cancer Novel Targets Mechanisms And Strategies
DOWNLOAD
Author : Xuyao Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-15
Combinational Immunotherapy Of Cancer Novel Targets Mechanisms And Strategies written by Xuyao Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-15 with Medical categories.
Cancer immunotherapy, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has revolutionized the paradigm in cancer treatment. However, the clinical outcome of immunotherapy varies considerably among patients and only a minority of patients achieve long-term clinical benefits. This is largely attributed to the fact that existing cancer immunotherapies, which concentrate on several classical targets (CTAL-4, PD-1/PD-L1, etc.) and limited types of immune cell populations (T cells), are insufficient to cope with the complexity of highly heterogeneous tumor microenvironment (TME). This calls for more efforts to not only expand our toolbox for manipulating anticancer immunity but also diversify our combinational strategies. To this end, it is urgent to deeper our understanding of cancer immunotherapy by using both experimental and computational methodologies from multi-scale perspectives: 1) novel targets from either tumor cells or non-tumor cells within TME (e.g., tumor intrinsic resistance drivers, new immune checkpoints, neoantigens), 2) in-depth characterization of more immune cell populations (e.g., macrophages, Tregs, B cells) and their interactions and dynamics within TME, 3) landscape of actionable targets in patient populations for combination design. These efforts will open the avenue of rational design of combinational immunotherapies, allowing researchers and clinicians to design novel targeting therapeutics or to optimally orchestrate combinatory strategies aiming to surmount resistance mechanisms and improve clinical outcomes.
Cutaneous Melanoma
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Author : Charles M. Balch
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 1985
Cutaneous Melanoma written by Charles M. Balch and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medical categories.
Community Series In Novel Insights Into Immunotherapy Targeting Tumor Microenvironment In Ovarian Cancer Volume I
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Author : Xiao Liang
language : en
Publisher: Frontiers Media SA
Release Date :
Community Series In Novel Insights Into Immunotherapy Targeting Tumor Microenvironment In Ovarian Cancer Volume I written by Xiao Liang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medical categories.
Personalized Management Of Gastric Cancer
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Author : Jia Wei
language : en
Publisher: Springer
Release Date : 2017-05-15
Personalized Management Of Gastric Cancer written by Jia Wei and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-15 with Medical categories.
This book offers essential information on basic and translational research in gastric cancer, while also illustrating potential opportunities for its application in clinical practice. Gastric cancer is the fourth-most-common cancer globally and the second-leading cause of cancer deaths. It is known to be a heterogeneous disease with varied responses to “one-size-fits-all” treatments. Expanding our knowledge of cancer cell genetics may help us to explore more effective treatments in gastric cancer. The research on molecular mechanisms and its clinical applications, both presented here, will help readers gain an in-depth understanding of gastric cancer and its effective treatment. The book’s four sections cover personalized medicine, precise regional therapy, immunotherapy and nanomedicine in gastric cancer. Each part presents the state of art, recent advances and the authors’ experiences. Moreover, several interesting cases are described to demonstrate how gastric cancer patients benefit from translational research. This informative and attractively presented book on precision treatment in gastric cancer, including experimental findings and clinical treatment options, offers a valuable resource for oncologists and graduate students working in the field of gastric cancer.
Molecular Oncology Principles And Recent Advances
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Author : Javier Camacho
language : en
Publisher: Bentham Science Publishers
Release Date : 2012-02-07
Molecular Oncology Principles And Recent Advances written by Javier Camacho and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-07 with Medical categories.
"Cancer is one of the major causes of death worldwide. Despite hundreds of clinical trials currently in progress for cancer patients, the success rate is still very low. Understanding the molecular aspects of cancer development, the discovery of new molecu"
Drug And Therapy Development For Triple Negative Breast Cancer
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Author : Pravin Kendrekar
language : en
Publisher: John Wiley & Sons
Release Date : 2023-06-12
Drug And Therapy Development For Triple Negative Breast Cancer written by Pravin Kendrekar and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-12 with Medical categories.
Drug and Therapy Development for Triple Negative Breast Cancer The first comprehensive and up-to-date compilation of modern diagnostic and treatment methods for triple negative breast cancer In Drug and Therapy Development for Triple Negative Breast Cancer, a team of distinguished practitioners delivers an in-depth and authoritative discussion of contemporary methods for treating triple negative breast cancer (TNBC). The editors have included material that covers its molecular causes, initial detection, diagnostic tools, treatment procedures, pharmacology, and new and experimental therapies—including nanotherapeutics and photothermal therapies. As the first comprehensive compilation of modern treatment methods for TNBC, this reference is an unmatched source of information about current and future treatment approaches, including machine learning methods for earlier detection and more accurate diagnosis. Readers will also find: A thorough introduction to HER receptors in breast cancers Comprehensive explorations of the etiology and therapy of hormone receptor-positive breast cancer and the early-stage diagnosis of breast cancer Application of artificial intelligence to breast cancer diagnosis New insights on the role of DNA replication stress and genome instability in breast cancer Perfect for medicinal and pharmaceutical chemists, Drug and Therapy Development for Triple Negative Breast Cancer will also benefit oncologists and professionals working in the pharmaceutical industry or in hospital settings.
Targeting The Tumor Microenvironment For A More Effective And Efficient Cancer Immunotherapy
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Author : Salem Chouaib
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-02
Targeting The Tumor Microenvironment For A More Effective And Efficient Cancer Immunotherapy written by Salem Chouaib and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-02 with categories.
Brain Cancers New Perspectives And Therapies
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Author : Maria Grazia Bottone
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-18
Brain Cancers New Perspectives And Therapies written by Maria Grazia Bottone and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-18 with Science categories.
Cytokine Based Immunotherapy Part A
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Author :
language : en
Publisher: Academic Press
Release Date : 2025-09-01
Cytokine Based Immunotherapy Part A written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-09-01 with Science categories.
Cytokine-Based immunotherapy, Volume 396, Part A delves into the intricate world of cytokines, vital signaling proteins that orchestrate the immune response and their pivotal role in modulating various immune functions. From their fundamental mechanisms to their therapeutic applications, this book offers a thorough examination of the latest trends and developments in leveraging cytokines for immunotherapy. The book includes chapters such as Cytokine-driven cancer immune evasion mechanisms, which explores how cytokines contribute to cancer cells' ability to evade the immune system. Cytokine-based immunotherapy in hematolymphoid malignancies is also explored, discussing the use of cytokines in treating blood cancers.Targeting TNF-alpha examines the immunotherapeutic approach for alleviating neuropathic pain. The key role of immunomodulatory cytokines for the development of novel nk cell-based cancer therapies focuses on the importance of cytokines in developing new cancer treatments. Finally, complexities in the clinical development of TGFβ inhibitors covers the challenges in creating inhibitors for TGFβ. - Provide a comprehensive overview of cytokine-based immunotherapy, covering key concepts, mechanisms, and applications in the field of immunotherapy - Details the role of various cytokines in modulating immune responses, including their functions in immune activation, regulation, and response to pathogens - Explores the current and emerging therapeutic applications of cytokine-based immunotherapy in treating various diseases, such as cancer, autoimmune disorders, and infectious diseases