Targeting The Tumor Microenvironment For A More Effective And Efficient Cancer Immunotherapy
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Targeting The Tumor Microenvironment For A More Effective And Efficient Cancer Immunotherapy
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Author : Salem Chouaib
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-02
Targeting The Tumor Microenvironment For A More Effective And Efficient Cancer Immunotherapy written by Salem Chouaib and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-02 with categories.
Nanobody Based Cancer Immunotherapy And Immunoimaging
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Author : Zahra Sharifzadeh
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-07
Nanobody Based Cancer Immunotherapy And Immunoimaging written by Zahra Sharifzadeh and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-07 with Science categories.
Oncoimmunology
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Author : Laurence Zitvogel
language : en
Publisher: Springer
Release Date : 2017-12-13
Oncoimmunology written by Laurence Zitvogel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-13 with Medical categories.
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
Nanotheranostics For Cancer Applications
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Author : Prakash Rai
language : en
Publisher: Springer
Release Date : 2018-11-12
Nanotheranostics For Cancer Applications written by Prakash Rai and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-12 with Technology & Engineering categories.
This book is the first to focus specifically on cancer nanotheranostics. Each of the chapters that make up this comprehensive volume is authored by a researcher, clinician, or regulatory agency member known for their expertise in this field. Theranostics, the technology to simultaneously diagnose and treat a disease, is a nascent field that is growing rapidly in this era of personalized medicine. As the need for cost-effective disease diagnosis grows, drug delivery systems that can act as multifunctional carriers for imaging contrast and therapy agents could provide unique breakthroughs in oncology. Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response and initiate secondary treatments if required. In oncology, chemotherapeutics have been routinely used. Some drugs have proven effective but all carry risks of adverse side effects. There is growing interest in using remotelytriggered drug delivery systems to limit cytotoxicity in the diseased area. This book reviews the use of theranostic nanoparticles for cancer applications over the past decade. First, it briefly discusses the challenges and limitations of conventional cancer treatments, and presents an overview of the use of nanotechnology in treating cancer. These introductory chapters are followed by those exploring cancer diagnosis and a myriad of delivery methods for nanotherapeutics. The book also addresses multifunctional platforms, treatment monitoring, and regulatory considerations. As a whole, the book aims to briefly summarize the development and clinical potential of various nanotheranostics for cancer applications, and to delineate the challenges that must be overcome for successful clinical development and implementation of such cancer theranostics.
Enhancing T Cell Function Innovations In Cancer Immunotherapy
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Author : Xuefeng Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2025-05-22
Enhancing T Cell Function Innovations In Cancer Immunotherapy written by Xuefeng Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-22 with Medical categories.
Cancer immunotherapy has been revolutionized by targeting specific immune subsets within the tumor microenvironment, where T cells play a pivotal role. Gene-engineered T cell strategies and immune checkpoint blockade (ICB) therapies have emerged as powerful approaches to reinvigorate tumor-infiltrating T cells, demonstrating considerable promise in clinical outcomes. However, challenges persist, particularly the limited in vivo persistence of adoptively transferred T cells and the variable patient response rates to ICB therapy. Key barriers include T cell exhaustion and the immunosuppressive milieu of the tumor microenvironment. Consequently, a deep understanding of functional modulation of these immune subsets is urgently needed to enhance the efficacy and safety of various T cell therapies, such as Tumor-infiltrating T lymphocytes (TIL-T), T cell receptor-engineered T cells (TCR-T), and Chimeric antigen receptor T cells (CAR-T). This Research Topic aims to explore and identify crucial targets and pathways for overcoming immune dysregulation in the tumor microenvironment. We seek to advance our understanding of these complexities by discussing innovative techniques that could augment T cell antitumor functionality. Contributions that unveil novel approaches or refine existing methods to boost the therapeutic potential of T cells in cancer treatment are particularly encouraged.
Oxford Textbook Of Cancer Biology
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Author : Francesco Pezzella
language : en
Publisher: Oxford University Press
Release Date : 2019-05-02
Oxford Textbook Of Cancer Biology written by Francesco Pezzella and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-02 with Medical categories.
The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field. Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development. The book then illustrates, as once cells become neoplastic, their signalling network is altered and pathological behaviour follows. It explores the changes that cancer cells can induce in nearby normal tissue, the new relationship established between them and the stroma, and the interaction between the immune system and tumour growth. The authors illustrate the contribution provided by high throughput techniques to map cancer at different levels, from genomic sequencing to cellular metabolic functions, and how information technology, with its vast amounts of data, is integrated with traditional cell biology to provide a global view of the disease. The effect of the different types of treatments on the biology of the neoplastic cells are explored to understand on the one side, why some treatments succeed, and on the other, how they can affect the biology of resistant and recurrent disease. The book concludes by summarizing what we know to date about cancer, and in what direction our understanding of cancer is moving. Edited by leading authorities in the field with an international team of contributors, this book is an essential resource for scholars and professionals working in the wide variety of sub-disciplines that make up today's cancer research and treatment community. It is written not only for consultation, but also for easy cover-to-cover reading.
Engineered Immune Cells In Cancer Immunotherapy Eicci
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Author : Cristina Maccalli
language : en
Publisher: Frontiers Media SA
Release Date : 2023-02-28
Engineered Immune Cells In Cancer Immunotherapy Eicci written by Cristina Maccalli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-28 with Medical categories.
Advances In Dna And Mrna Based Strategies For Cancer Immunotherapy Part B
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Author :
language : en
Publisher: Academic Press
Release Date : 2025-08-01
Advances In Dna And Mrna Based Strategies For Cancer Immunotherapy Part B written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-08-01 with Medical categories.
Advances in Immunology, Volume 166, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. - Presents current developments and comprehensive reviews in immunology - Provides the latest in a longstanding and respected serial on the subject matter - Focuses on recent advances in the field of immunology
Targeting Key Cellular Signaling Network For Cancer Chemotherapy And Immunotherapy
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Author : Bo Zhai
language : en
Publisher: Frontiers Media SA
Release Date : 2024-06-04
Targeting Key Cellular Signaling Network For Cancer Chemotherapy And Immunotherapy written by Bo Zhai and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-04 with Medical categories.
The cellular signaling network refers to the complex system formed by the interactions between various signaling molecules and receptors within and between cells. It consists of multiple signaling pathways that mediate intricate cellular interactions both internally and externally. The development of cancer is closely associated with the intricate signaling transduction network within cells, where multiple signaling pathways are interconnected and collectively regulate the biological phenotypes of tumor cells.
Combinational Immunotherapy Of Cancer Novel Targets Mechanisms And Strategies
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Author : Xuyao Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-15
Combinational Immunotherapy Of Cancer Novel Targets Mechanisms And Strategies written by Xuyao Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-15 with Medical categories.
Cancer immunotherapy, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has revolutionized the paradigm in cancer treatment. However, the clinical outcome of immunotherapy varies considerably among patients and only a minority of patients achieve long-term clinical benefits. This is largely attributed to the fact that existing cancer immunotherapies, which concentrate on several classical targets (CTAL-4, PD-1/PD-L1, etc.) and limited types of immune cell populations (T cells), are insufficient to cope with the complexity of highly heterogeneous tumor microenvironment (TME). This calls for more efforts to not only expand our toolbox for manipulating anticancer immunity but also diversify our combinational strategies. To this end, it is urgent to deeper our understanding of cancer immunotherapy by using both experimental and computational methodologies from multi-scale perspectives: 1) novel targets from either tumor cells or non-tumor cells within TME (e.g., tumor intrinsic resistance drivers, new immune checkpoints, neoantigens), 2) in-depth characterization of more immune cell populations (e.g., macrophages, Tregs, B cells) and their interactions and dynamics within TME, 3) landscape of actionable targets in patient populations for combination design. These efforts will open the avenue of rational design of combinational immunotherapies, allowing researchers and clinicians to design novel targeting therapeutics or to optimally orchestrate combinatory strategies aiming to surmount resistance mechanisms and improve clinical outcomes.