Implication Of Quorum Sensing System In Biofilm Formation And Virulence


Implication Of Quorum Sensing System In Biofilm Formation And Virulence
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Implication Of Quorum Sensing System In Biofilm Formation And Virulence


Implication Of Quorum Sensing System In Biofilm Formation And Virulence
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Author : Pallaval Veera Bramhachari
language : en
Publisher: Springer
Release Date : 2019-01-28

Implication Of Quorum Sensing System In Biofilm Formation And Virulence written by Pallaval Veera Bramhachari and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-28 with Medical categories.


This book illustrates the importance and significance of Quorum sensing (QS), it’s critical roles in regulating diverse cellular functions in microbes, including bioluminescence, virulence, pathogenesis, gene expression, biofilm formation and antibiotic resistance. Microbes can coordinate population behavior with small molecules called autoinducers (AHL) which serves as a signal of cellular population density, triggering new patterns of gene expression for mounting virulence and pathogenesis. Therefore, these microbes have the competence to coordinate and regulate explicit sets of genes by sensing and communicating amongst themselves utilizing variety of signals. This book descry emphasizes on how bacteria can coordinate an activity and synchronize their response to external signals and regulate gene expression. The chapters of the book provide the recent advancements on various functional aspects of QS systems in different gram positive and gram negative organisms. Finally, the book also elucidates a comprehensive yet a representative description of a large number of challenges associated with quorum sensing signal molecules viz. virulence, pathogenesis, antibiotic synthesis, biosurfactants production, persister cells, cell signaling and biofilms, intra and inter-species communications, host-pathogen interactions, social interactions & swarming migration in biofilms.



Implication Of Quorum Sensing And Biofilm Formation In Medicine Agriculture And Food Industry


Implication Of Quorum Sensing And Biofilm Formation In Medicine Agriculture And Food Industry
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Author : Pallaval Veera Bramhachari
language : en
Publisher: Springer Nature
Release Date : 2019-11-26

Implication Of Quorum Sensing And Biofilm Formation In Medicine Agriculture And Food Industry written by Pallaval Veera Bramhachari and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-26 with Medical categories.


The book illustrates the role of quorum sensing in the food industry, agriculture, veterinary sciences, and medicine. It highlights the importance of quorum sensing in regulating diverse cellular functions in microbes, including virulence, pathogenesis, controlled-gene expression systems, and antibiotic resistance. This book also describes the role of quorum sensing in survival behavior and antibiotic resistance in bacteria. Further, it reviews the major role played by quorum sensing in food spoilage, biofilm formation, and food-related pathogenesis. It also explores the methods for the detection and quantification of quorum sensing signals. It also presents antimicrobial and anti-quorum sensing activities of medicinal plants. Finally, the book elucidates a comprehensive yet representative description of basic and applied aspects of quorum sensing inhibitors. This book serves an ideal guide for researchers to understand the implications of quorum sensing in the food industry, medicine, and agriculture.



Implication Of Quorum Sensing And Biofilm Formation In Medicine Agriculture And Food Industry


Implication Of Quorum Sensing And Biofilm Formation In Medicine Agriculture And Food Industry
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Author : Pallaval Veera Bramhachari
language : en
Publisher:
Release Date : 2019

Implication Of Quorum Sensing And Biofilm Formation In Medicine Agriculture And Food Industry written by Pallaval Veera Bramhachari and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Agriculture categories.


The book illustrates the role of quorum sensing in the food industry, agriculture, veterinary sciences, and medicine. It highlights the importance of quorum sensing in regulating diverse cellular functions in microbes, including virulence, pathogenesis, controlled-gene expression systems, and antibiotic resistance. This book also describes the role of quorum sensing in survival behavior and antibiotic resistance in bacteria. Further, it reviews the major role played by quorum sensing in food spoilage, biofilm formation, and food-related pathogenesis. It also explores the methods for the detection and quantification of quorum sensing signals. It also presents antimicrobial and anti-quorum sensing activities of medicinal plants. Finally, the book elucidates a comprehensive yet representative description of basic and applied aspects of quorum sensing inhibitors. This book serves an ideal guide for researchers to understand the implications of quorum sensing in the food industry, medicine, and agriculture.



Fundamentals Of And Applications Based On Quorum Sensing And Quorum Sensing Interference


Fundamentals Of And Applications Based On Quorum Sensing And Quorum Sensing Interference
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Author : Cristina García-Aljaro
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-23

Fundamentals Of And Applications Based On Quorum Sensing And Quorum Sensing Interference written by Cristina García-Aljaro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-23 with categories.


Background Bacteria use quorum sensing (QS) circuits to coordinate various activities (among which biofilm formation and the expression of virulence factors) based on the presence of signaling molecules. Different families of signal molecules have been identified in Gram positive and Gram negative bacteria (e.g. autoinducer peptides and acyl homoserine lactones). Similarly, different quorum sensing antagonists interfering with these system have been found in nature, promoting a new and promising field of research, quorum sensing interference. One of the most intensively studied applications of quorum sensing interference is its use as an alternative or synergycally with antibiotics to fight (antibiotic-resistant) bacterial pathogens. Many studies have been published claiming quorum sensing inhibitory activity of natural and synthetic compounds. However, after decades of research, several questions regarding the suitability of this approach to fight bacterial pathogens remain unanswered, including the risk that pathogens will develop resistance against quorum quenching. Meanwhile, the interest in quorum sensing has increased considerably, and this has broadened the fields where it can find biotechnological, environmental and industrial applications, such as anti biofouling, steering fermentations, bioremediation and wastewater treatment. Goal and scope The goal of this Research Topic is to broaden the knowledge of the phenotypes regulated by quorum sensing and the advances in quorum sensing interference. Deciphering microorganism language and the different phenotypes regulated by microbial signalling systems is a frontier for the development of new tools for the management of microorganisms to fulfil human needs with a broad application in different areas such as medicine, environmental sciences and industry.



Trends In Quorum Sensing And Quorum Quenching


Trends In Quorum Sensing And Quorum Quenching
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Author : V. Ravishankar Rai
language : en
Publisher: CRC Press
Release Date : 2020-05-04

Trends In Quorum Sensing And Quorum Quenching written by V. Ravishankar Rai and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-04 with Science categories.


The book on Trends in Quorum Sensing and Quorum Quenching: New Perspectives and Applications focuses on the recent advances in the field of quorum sensing in bacteria and the novel strategies developed for quorum sensing inhibition. The topics covered are multidisciplinary and wide-ranging,and includes quorum sensing phenomenon in pathogenic bacteria, food spoilers, and agriculturally relevant bacteria. The applications of quorum sensing inhibitors such as small molecules, bioactives, natural compounds, and quorum quenching enzymes in controlling bacterial infections in clinical settings, agriculture and aquaculture are discussed. The potential use of quorum quenching enzymes for mitigating biofouling is also covered. Special focus is given to exploring quorum sensing inhibitors from microbes and flora inhabiting biodiversity rich regions including tropical rain forests and marine environments. Key features: Covers the fundamental aspects, the progress and challenges in the field of quorum sensing and quorum quenching Reviews quorum sensing in Gram-positive and Gram-negative bacteria of clinical, agricultural, and industrial relevance Discusses the application and future trends of quorum sensing inhibitors from lab to clinical and environmental settings Provides comprehensive coverage on molecular mechanisms in bacterial signaling



Quorum Sensing Vs Quorum Quenching A Battle With No End In Sight


Quorum Sensing Vs Quorum Quenching A Battle With No End In Sight
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Author : Vipin Chandra Kalia
language : en
Publisher: Springer
Release Date : 2016-08-23

Quorum Sensing Vs Quorum Quenching A Battle With No End In Sight written by Vipin Chandra Kalia and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Science categories.


Microbial relationships with all life forms can be as free living, symbiotic or pathogenic. Human beings harbor 10 times more microbial cells than their own. Bacteria are found on the skin surface, in the gut and other body parts. Bacteria causing diseases are the most worrisome. Most of the infectious diseases are caused by bacterial pathogens with an ability to form biofilm. Bacteria within the biofilm are up to 1000 times more resistant to antibiotics. This has taken a more serious turn with the evolution of multiple drug resistant bacteria. Health Departments are making efforts to reduce high mortality and morbidity in man caused by them. Bacterial Quorum sensing (QS), a cell density dependent phenomenon is responsible for a wide range of expressions such as pathogenesis, biofilm formation, competence, sporulation, nitrogen fixation, etc. Majority of these organisms that are important for medical, agriculture, aquaculture, water treatment and remediation, archaeological departments are: Aeromonas, Acinetobacter, Bacillus, Clostridia, Enterococcus, Pseudomonas, Vibrio and Yersinia spp. Biosensors and models have been developed to detect QS systems. Strategies for inhibiting QS system through natural and synthetic compounds have been presented here. The biotechnological applications of QS inhibitors (QSIs) in diverse areas have also been dealt with. Although QSIs do not affect growth and are less likely to impose selective pressure on bacteria, however, a few reports have raised doubts on the fate of QSIs. This book addresses a few questions. Will bacteria develop mechanisms to evade QSIs? Are we watching yet another defeat at the hands of bacteria? Or will we be acting intelligently and survive the onslaughts of this Never Ending battle?



Quorum Sensing


Quorum Sensing
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Author : Giuseppina Tommonaro
language : en
Publisher: Academic Press
Release Date : 2019-04-15

Quorum Sensing written by Giuseppina Tommonaro and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-15 with Medical categories.


Quorum sensing (QS) is a process of bacterial cooperative behaviour that has an effect on gene regulation. This cell-to-cell communication system involves the production of signalling molecules according to cell density and growth stage. Virulence, the ability to infest a habitat and cause disease, is also governed by such communication signals. Quorum Sensing: Molecular mechanism and biotechnological application collects, describes and summarizes the most interesting results obtained from experts working on QS mechanisms. It contributes to the understanding of the molecular basis that regulates this mechanism, and describes new findings in fields of application. This volume describes the QS mechanism from its molecular basis to medical applications such as antibiotic therapy and involvement of QS in pathologies. This reference also analyzes its potential use in biotechnological applications such as food packaging, drug delivery, and marine biofilm. The broad scope of this title will be of significant use to researchers across several fields with interest in QS, including to microbiologists, chemists, biochemists and ecologists. Describes Quorum Sensing (QS) mechanisms from their molecular basis, to their clinical applications Spans several fields in relation to QS, including microbiology, chemistry, biochemistry and ecology Considers QS as an approach to the discovery of new antibiotics Looks at QS as a means to understand the microbial world and towards use of bacteria and their products in biotechnological applications Summarizes key results on QS mechanisms' molecular basis and fields of application



Bacterial Cell To Cell Communication


Bacterial Cell To Cell Communication
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Author : Donald R. Demuth
language : en
Publisher: Cambridge University Press
Release Date : 2006-02-23

Bacterial Cell To Cell Communication written by Donald R. Demuth and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-02-23 with Science categories.


Many bacterial diseases are caused by organisms growing together as communities or biofilms. These microorganisms have the capacity to coordinately regulate specific sets of genes by sensing and communicating amongst themselves utilizing a variety of signals. This book examines the mechanisms of quorum sensing and cell-to-cell communication in bacteria and the roles that these processes play in regulating virulence, bacterial interactions with host tissues, and microbial development. Recent studies suggest that microbial cell-to-cell communication plays an important role in the pathogenesis of a variety of disease processes. Furthermore, some bacterial signal molecules may possess immunomodulatory activity. Thus, understanding the mechanisms and outcomes of bacterial cell-to-cell communication has important implications for appreciating host-pathogen interactions and ultimately may provide new targets for antimicrobial therapies that block or interfere with these communication networks.



Natural Products


Natural Products
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Author : Moupriya Nag
language : en
Publisher: CRC Press
Release Date : 2023-12-01

Natural Products written by Moupriya Nag and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-01 with Science categories.


Microbial biofilm plays an important role in the life cycle of microorganisms surviving in diverse and harsh environments such as extremes of temperatures, pH, salinity, nutrient scarcity etc. Biofilm formation is a survival strategy adopted by microorganisms allowing colonization in new niches by dispersal of microbes from the microbial clusters embedded within an outer polymer layer produced by the microorganism itself. This layer comprises of extracellular polymeric substances (EPS) that helps the indwelling microbes to grow and divide in a protected environment against invaders like antimicrobial agents, surfactant, biocides and phagocytic cells of host organisms. Thus, EPS matrix prevents the penetration of antimicrobials thereby allowing the indwelling microbes to survive and give rise to antimicrobial resistance posing threat to human health. The present book highlights a detailed analysis of the mechanism of biofilm formation in both Gram positive and Gram-negative bacteria and the role of quorum sensing signaling mechanism in the genetic regulation pathway. The book titled "Natural Products: Alternative therapeutics as Quorum Sensing (QS) inhibitors" provides a detailed and systematic review of mechanism of quorum sensing in both Gram positive and Gram-negative bacteria and alternative pharmacological developments as a potent solution to the rise of antimicrobial resistance during biofilm formation. Features: A systematic overview of the mechanism of quorum sensing in the development of microbial biofilms Biofilm formation and its role in the emergence of antimicrobial resistance. Recent pharmacological development of antibiofilm remedies involving biogenic compounds. This book serves as a reference book for researchers investigating the progression of events during microbial biofilm formation starting from the genetic cascade regulating quorum sensing to secretion of autoinducers and design of safer methodologies for the successful eradication of microbial biofilm. It may also be used as a textbook for a undergraduate level course in microbiology or microbial biotechnology.



Bacterial Signaling


Bacterial Signaling
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Author : Reinhard Krämer
language : en
Publisher: John Wiley & Sons
Release Date : 2009-12-09

Bacterial Signaling written by Reinhard Krämer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-09 with Science categories.


Providing a comprehensive insight into cellular signaling processes in bacteria with a special focus on biotechnological implications, this is the first book to cover intercellular as well as intracellular signaling and its relevance for biofilm formation, host pathogen interactions, symbiotic relationships, and photo- and chemotaxis. In addition, it deals in detail with principal bacterial signaling mechanisms -- making this a valuable resource for all advanced students in microbiology. Dr. Krämer is a world-renowned expert in intracellular signaling and its implications for biotechnology processes, while Dr. Jung is an expert on intercellular signaling and its relevance for biomedicine and agriculture.