Improving And Accelerating Therapeutic Development For Nervous System Disorders
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Improving And Accelerating Therapeutic Development For Nervous System Disorders
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2014-02-06
Improving And Accelerating Therapeutic Development For Nervous System Disorders written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-06 with Medical categories.
Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Therapeutic Development In The Absence Of Predictive Animal Models Of Nervous System Disorders
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-06-24
Therapeutic Development In The Absence Of Predictive Animal Models Of Nervous System Disorders written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-24 with Medical categories.
Compared with other disease areas, central nervous system (CNS) disorders have had the highest failure rate for new compounds in advanced clinical trials. Most CNS drugs fail because of efficacy, and the core issue underlying these problems is a poor understanding of disease biology. Concern about the poor productivity in neuroscience drug development has gained intensity over the past decade, amplified by a retraction in investment from the pharmaceutical industry. This retreat by industry has been fueled by the high failure rate of compounds in advanced clinical trials for nervous system disorders. In response to the de-emphasis of CNS disorders in therapeutic development relative to other disease areas such as cancer, metabolism, and autoimmunity, the National Academies of Sciences, Engineering, and Medicine initiated a series of workshops in 2012 to address the challenges that have slowed drug development for nervous system disorders. Motivated by the notion that advances in genetics and other new technologies are beginning to bring forth new molecular targets and identify new biomarkers, the Academies hosted the third workshop in this series in September 2016. Participants discussed opportunities to accelerate early stages of drug development for nervous system disorders in the absence of animal models that reflect disease and predict efficacy. This publication summarizes the presentations and discussions from the workshop.
Translational Medicine In Cns Drug Development
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Author : George G. Nomikos
language : en
Publisher: Academic Press
Release Date : 2019-06-18
Translational Medicine In Cns Drug Development written by George G. Nomikos and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-18 with Medical categories.
Translational Medicine in CNS Drug Development, Volume 29, is the first book of its kind to offer a comprehensive overview of the latest developments in translational medicine and biomarker techniques. With extensive coverage on all aspects of biomarkers and personalized medicine, and numerous chapters devoted to the best strategies for developing drugs that target specific disorders, this book presents an essential reference for researchers in neuroscience and pharmacology who need the most up-to-date techniques for the successful development of drugs to treat central nervous system disorders. Despite increases in the number of individuals suffering from CNS-related disorders, the development and approval of drugs for their treatment have been hampered by inefficiencies in advancing compounds from preclinical discovery to the clinic. However, in the past decades, game-changing strides have been made in our understanding of the pathophysiology of CNS disorders and the relationship of drug exposure in plasma and CNS to pharmacodynamic measures in both animals and humans. - Includes comprehensive coverage of biomarker tools and the role of personalized medicine in CNS drug development - Discusses strategies for drug development for a full range of CNS indications, with particular attention to neuropsychiatric and neurocognitive disorders - Includes chapters written by international experts from industry and academia
Financial Incentives To Encourage Development Of Therapies That Address Unmet Medical Needs For Nervous System Disorders
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2015-10-22
Financial Incentives To Encourage Development Of Therapies That Address Unmet Medical Needs For Nervous System Disorders written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-22 with Medical categories.
The Institute of Medicine (IOM) Forum on Neuroscience and Nervous System Disorders, in collaboration with the IOM Forum on Drug Discovery, Development, and Translation, convened a workshop on January 20-21, 2015, to explore policy changes that might increase private sector investment in research and development innovation that fills unmet medical needs for central nervous system (CNS) disorders. Workshop participants strategized about how to incentivize companies to fortify their CNS drug development programs, shrinking obstacles that currently deter ventures. Representatives from academia, government agencies, patient groups, and industry gathered to share information and viewpoints, and to brainstorm about budget-neutral policy changes that could help widen the pipeline toward drugs that address unmet needs for CNS disorders. This report summarizes the presentations and discussion of the workshop.
Microfluidics In Pharmaceutical Sciences
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Author : Dimitrios A. Lamprou
language : en
Publisher: Springer Nature
Release Date : 2024-06-21
Microfluidics In Pharmaceutical Sciences written by Dimitrios A. Lamprou and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-21 with Medical categories.
The book covers the basics of microfluidics, current applications in areas such as formulation, drug delivery, drug screening and development, monitoring and diagnostics, and case studies from a teaching perspective to undergraduate and postgraduate students, allowing application of the content in a flipped classroom. Multiple choice questions are included at the end of each chapter. All chapter authors are pioneers and world leaders. This is an ideal book for students, researchers, and industry professionals working on microfluidics in the pharmaceutical sciences.
Bioelectronic Medicines New Frontiers In Autonomic Neuromodulation
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Author : Arun Sridhar
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-05
Bioelectronic Medicines New Frontiers In Autonomic Neuromodulation written by Arun Sridhar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-05 with Science categories.
Comprehensive Medicinal Chemistry Iii
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Author :
language : en
Publisher: Elsevier
Release Date : 2017-06-03
Comprehensive Medicinal Chemistry Iii written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-03 with Technology & Engineering categories.
Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs
Targeted Therapy For The Central Nervous System
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Author : Viral Patel
language : en
Publisher: Elsevier
Release Date : 2024-10-07
Targeted Therapy For The Central Nervous System written by Viral Patel and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-07 with Medical categories.
Targeted Therapy for the Central Nervous System: Formulation, Clinical Challenges, and Regulatory Strategies presents research on various delivery methods of drugs to the central nervous system and brain. This volume examines targeted therapies for neurodegenerative disorders and succinctly outlines the future of drug delivery systems, highlighting significant advancements specifically relating to central nervous system delivery. This book will be of great interest to researchers working in the field of neuroscience and pharmacology as well as clinicians (pharmacists, radiologists, psychiatrists). - Provides a current, thorough means on how drugs are delivered to the neurological system - Figures a connection amongst the physiology of drug delivery pertaining to the central nervous system, fundamentals of drug delivery, and distribution principles - Gives an accounting of clinical trials and regulatory approaches for the formulations targeting brain
Biomaterials And Neurodegenerative Disorders
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Author : Gaurav Kumar
language : en
Publisher: Springer Nature
Release Date : 2025-01-22
Biomaterials And Neurodegenerative Disorders written by Gaurav Kumar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-22 with Science categories.
The book covers the fundamental aspects of biomaterials, including their introduction, types, synthesis, and characterization. It delves into the field of neuro-compatible biomaterials, examining nervous tissue response and the role of biomaterials in neuroprotection. It discusses clinical trials and applications along with intellectual property rights in neuroprotective biomaterials. The book also explores the innovative neuro-targeted drug delivery system and its potential in improving treatment outcomes. Lastly, it explores biomaterials' impact on neurodegeneration and neuro diagnosis, providing valuable insights for researchers, academicians and doctoral students working in the field of Neuroscience, Neuroprotection, Biomaterial based Neurotherapeutics, Biomaterial based Neuro diagnosis and Biomaterial mediated drug delivery.
Introduction For Heart 3d Bioprinting Book 3
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Author : Edenilson Brandl
language : en
Publisher: Edenilson Brandl
Release Date : 2024-05-18
Introduction For Heart 3d Bioprinting Book 3 written by Edenilson Brandl and has been published by Edenilson Brandl this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-18 with Medical categories.
The field of 3D bioprinting stands at the forefront of medical and technological innovation, promising to revolutionize healthcare as we know it. This book, Introduction for Heart 3D Bioprinting - The 3D Bioprinting + Introduction for Heart 3D Bioprinting, is conceived as a comprehensive guide to this rapidly evolving domain, focusing particularly on the applications of 3D bioprinting in heart disease treatment and the broader implications for medical research and practice. In recent years, advances in 3D bioprinting have paved the way for the creation of complex biological structures, including tissues and organs, which hold the potential to transform therapeutic strategies and outcomes. This technology's ability to fabricate patient-specific organs from biocompatible materials offers a glimpse into a future where organ shortages and transplant rejections become relics of the past. The contents of this book are meticulously structured to provide a thorough overview of 3D bioprinting, beginning with fundamental concepts and progressing to intricate applications. We delve into topics such as the use of transparent biomaterials for sustainable organ printing, innovations in vascularization, and the integration of advanced software in the creation of bioprinted models. Each chapter is designed to highlight both the immense potential and the challenges faced in this field. Particular emphasis is placed on the bioprinting of heart tissues, given the critical need for effective treatments for cardiovascular diseases, which remain the leading cause of death globally. We explore the latest research, materials, and methods used to print functional heart tissues and organs, aiming to bridge the gap between current medical capabilities and future possibilities. Additionally, this book addresses the broader impact of 3D bioprinting on healthcare, including its economic implications, ethical considerations, and the potential for personalized medicine. Topics such as the bioprinting of organs for pharmaceutical testing, the creation of models for studying rare and complex diseases, and the production of personalized implants are discussed in detail. This book is intended for a diverse audience, including medical professionals, researchers, students, and anyone with a keen interest in the future of healthcare. By providing a comprehensive overview of current advancements and future directions, we hope to inspire continued innovation and collaboration in the field of 3D bioprinting. As you embark on this journey through the pages of Introduction for Heart 3D Bioprinting, we invite you to imagine the transformative possibilities that lie ahead and to contribute to the ongoing efforts to make these possibilities a reality. The future of medicine is being printed layer by layer, and we are just beginning to uncover the profound ways in which this technology will shape our world.