Improving The Clinical Effectiveness Of Metagenomic Next Generation Sequencing Mngs In Infection Disease Diagnosis And Treatment Linking The Ngs Specialists And Clinicians Volume Ii
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Improving The Clinical Effectiveness Of Metagenomic Next Generation Sequencing Mngs In Infection Disease Diagnosis And Treatment Linking The Ngs Specialists And Clinicians Volume Ii
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Author : Beiwen Zheng
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-28
Improving The Clinical Effectiveness Of Metagenomic Next Generation Sequencing Mngs In Infection Disease Diagnosis And Treatment Linking The Ngs Specialists And Clinicians Volume Ii written by Beiwen Zheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-28 with Science categories.
Timely and accurate pathogen diagnosis is critical for effective treatment, outbreak prevention and precise antibiotics administration of infectious diseases, which remains a challenge in clinical practice. Metagenomic next generation sequencing (mNGS) allows researchers and laboratory specialists to analyze the mixed collection of sequencing reads in human clinical samples, including sequences from bacteria, viruses, fungi and parasites besides the host. This new technology shows great potential in pathogen diagnosis. The sensitivity and faster turnaround time are higher than conventional clinical microbiology tests, especially for fastidious and atypical pathogens. However, current mNGS based pathogen detection and diagnosis are facing challenges from both technical and practical aspects. First, sequencing noise can be introduced from different steps such as samples preparation, sequencing, data analysis and reporting algorithm. Also, the interpretation of the results such as detection limits and detection rates are not straightforward to clinicians, compared with traditional culture-based technologies. Such challenges and considerations should be fully addressed before the wild application of mNGS as a pathogen detection tool. Further, these clarifications might help to properly find the best clinical application scenarios, refine the medical treatments, and improve the clinical effectiveness of mNGS in complex infectious diseases. This Research Topic is focused on the application of mNGS for infectious diseases diagnosis and treatment, including experiment process and clinical usage. Its purpose is to level up the clarification of NGS process, to support the development of efficient experiment methods, data interpretation algorithms and to report good examples of related clinical applications. We hope this Research Topic could facilitate the discovery of novel methods and help NGS specialists and clinicians to know mutual concerns and work together to improve the clinical effectiveness of mNGS.
Improving The Clinical Effectiveness Of Metagenomic Next Generation Sequencing Mngs In Infection Disease Diagnosis And Treatment Linking The Ngs Specialists And Clinicians
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Author :
language : en
Publisher: Frontiers Media SA
Release Date : 2023-10-17
Improving The Clinical Effectiveness Of Metagenomic Next Generation Sequencing Mngs In Infection Disease Diagnosis And Treatment Linking The Ngs Specialists And Clinicians written by and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-17 with Science categories.
Pediatric Osteoarticular Infections
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Author : Anil Agarwal
language : en
Publisher: JP Medical Ltd
Release Date : 2013-01-30
Pediatric Osteoarticular Infections written by Anil Agarwal and has been published by JP Medical Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-30 with Medical categories.
This concise guide brings orthopaedic surgeons and paediatricians up to date with the latest developments in the management of bone and joint (osteoarticular) infections in children. Beginning with an introduction to the causes and development of osteoarticular disorders, the following chapters discuss their clinical features, laboratory diagnosis and treatment options, both surgical and conservative. Each chapter describes a different infection and its management, with a separate chapter examining drug-resistant osteoarticular tuberculosis and co-infection with HIV. The final section discusses advances and research in the condition. Key points Concise guide to the diagnosis and management of bone and joint infections in children Each chapter discusses a different infection and covers conservative and surgical treatment Final chapter describes new advances and research Includes more than 150 full colour images and illustrations
Pandemics Insurance And Social Protection
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Author : María del Carmen Boado-Penas
language : en
Publisher: Springer Nature
Release Date : 2022
Pandemics Insurance And Social Protection written by María del Carmen Boado-Penas and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Applied mathematics categories.
This open access book collects expert contributions on actuarial modelling and related topics, from machine learning to legal aspects, and reflects on possible insurance designs during an epidemic/pandemic. Starting by considering the impulse given by COVID-19 to the insurance industry and to actuarial research, the text covers compartment models, mortality changes during a pandemic, risk-sharing in the presence of low probability events, group testing, compositional data analysis for detecting data inconsistencies, behaviouristic aspects in fighting a pandemic, and insurers' legal problems, amongst others. Concluding with an essay by a practicing actuary on the applicability of the methods proposed, this interdisciplinary book is aimed at actuaries as well as readers with a background in mathematics, economics, statistics, finance, epidemiology, or sociology.
Advances In Bioinformatics
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Author : Vijai Singh
language : en
Publisher: Springer Nature
Release Date :
Advances In Bioinformatics written by Vijai Singh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Psittacosis Surveillance
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Author : Center for Disease Control
language : en
Publisher:
Release Date : 1978
Psittacosis Surveillance written by Center for Disease Control and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Psittacosis categories.
Computational Intelligence Techniques For Combating Covid 19
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Author : Sandeep Kautish
language : en
Publisher: Springer Nature
Release Date : 2021
Computational Intelligence Techniques For Combating Covid 19 written by Sandeep Kautish and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Biomedical engineering categories.
This book presents the latest cutting edge research, theoretical methods, and novel applications in the field of computational intelligence and computational biological approaches that are aiming to combat COVID-19. The book gives the technological key drivers behind using AI to find drugs that target the virus, shedding light on the structure of COVID-19, detecting the outbreak and spread of new diseases, spotting signs of a COVID-19 infection in medical images, monitoring how the virus and lockdown is affecting mental health, and forecasting how COVID-19 cases and deaths will spread across cities and why. Further, the book helps readers understand computational intelligence techniques combating COVID-19 in a simple and systematic way. Provides a comprehensive reference covering innovations and development of theories, conceptual models and computational algorithms focused on COVID-19; Asserts all relevant research, key themes, complex adaptive systems, metrics and paradigms dedicated towards COVID-19, enabled with evolutionary methods of computational sciences; Explores how AI and computational techniques can help to predict which patients with the virus would go on to develop Acute Respiratory Distress Syndrome (ARDS).
Metagenomics For Microbiology
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Author : Jacques Izard
language : en
Publisher: Academic Press
Release Date : 2014-11-07
Metagenomics For Microbiology written by Jacques Izard and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-07 with Science categories.
Concisely discussing the application of high throughput analysis to move forward our understanding of microbial principles, Metagenomics for Microbiology provides a solid base for the design and analysis of omics studies for the characterization of microbial consortia. The intended audience includes clinical and environmental microbiologists, molecular biologists, infectious disease experts, statisticians, biostatisticians, and public health scientists. This book focuses on the technological underpinnings of metagenomic approaches and their conceptual and practical applications. With the next-generation genomic sequencing revolution increasingly permitting researchers to decipher the coding information of the microbes living with us, we now have a unique capacity to compare multiple sites within individuals and at higher resolution and greater throughput than hitherto possible. The recent articulation of this paradigm points to unique possibilities for investigation of our dynamic relationship with these cellular communities, and excitingly the probing of their therapeutic potential in disease prevention or treatment of the future. Expertly describes the latest metagenomic methodologies and best-practices, from sample collection to data analysis for taxonomic, whole shotgun metagenomic, and metatranscriptomic studies Includes clear-headed pointers and quick starts to direct research efforts and increase study efficacy, eschewing ponderous prose Presented topics include sample collection and preparation, data generation and quality control, third generation sequencing, advances in computational analyses of shotgun metagenomic sequence data, taxonomic profiling of shotgun data, hypothesis testing, and mathematical and computational analysis of longitudinal data and time series. Past-examples and prospects are provided to contextualize the applications.
Infectious Eye Diseases
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Author : Alejandro Rodriguez-Garcia
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-10-27
Infectious Eye Diseases written by Alejandro Rodriguez-Garcia and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-27 with Medical categories.
Infectious eye disorders represent one of the most feared, sight-threatening, and challenging clinical ocular conditions. Visual loss due to eye infection significantly impacts patients’ productivity and quality of life. The development of accurate diagnostic tests and better treatment alternatives results from intensive and innovative medical research committed to improving the standard of care of patients suffering from these blinding diseases. This book focuses on the most recent advances in diagnostic techniques for common infectious disorders, including viral, fungal, and contact lens-related keratitis, infectious uveitis, endophthalmitis, and COVID-19-related eye infection. It also describes the current therapeutic strategies that significantly reduce the rate of ocular complications and improve the visual outcome of patients suffering from such devastating disorders.
Integrated Omics Approaches To Infectious Diseases
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Author : Saif Hameed
language : en
Publisher: Springer
Release Date : 2022-07-21
Integrated Omics Approaches To Infectious Diseases written by Saif Hameed and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-21 with Medical categories.
This book examines applications of multi-omics approaches for understanding disease etiology, pathogenesis, host-pathogen interactions. It also analyzes the genetics, immunological and metabolic mechanisms underlying the infections. The book also explores genomics, transcriptomics, translational-omics, and metabolomics approaches to understand the pathogenesis and identify potential drug targets. It reviews the role of epigenetic reprogramming in shaping the host-pathogen interactions and presents bioinformatics application in the identification of drug targets. Further, it examines the potential applications of RNA sequencing and non-coding RNA profiling to identify the pathogenesis. Lastly, it offers the current challenges, technological advances, and prospects of using multi-omics technologies in infectious biology.