In Silico Approach Towards Magnetic Fluid Hyperthermia Of Cancer Treatment
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In Silico Approach Towards Magnetic Fluid Hyperthermia Of Cancer Treatment
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Author : Muhammad Suleman
language : en
Publisher: Elsevier
Release Date : 2023-02-28
In Silico Approach Towards Magnetic Fluid Hyperthermia Of Cancer Treatment written by Muhammad Suleman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-28 with Medical categories.
In Silico Approach Towards Magnetic Fluid Hyperthermia in Cancer Treatment: Modeling and Simulation presents mathematical modeling and simulation approaches contrary to costly and time consuming in-vivo and in-vitro studies. Finite element method-based models of all hyperthermia processes of liver, brain and breast tumors are simulated on COMSOL Multiphysics software. Problems of constant versus variable heat sources, the backflow problem, the enhanced permeation and retention effect, the flow around Happel’s sphere in cells model structure, the deformation effect in poroelastic brain tumor, 3D flow through porous tissue, the reacting nanofluid flows, and optimization of parameters have been simulated for quantitative analysis. This important reference aids in hyperthermia treatment planning in clinical applications and provides an important compendium for practitioners as well as non-medical practicing scientists and engineers and is resource for both research and medical practice in hyperthermia treatment planning in clinical applications. Includes the diversities of cancer treatment modalities for their eradication with minimum damage to surrounding normal tissue Addresses tumors of different organs including liver, brain and breast Deals with mathematical modeling and simulation approaches contrary to costly and time consuming in-vivo and in-vitro studies Provides insights on how to use hyperthermia in cancer treatments in addition to other conventional types of treatments
Magnetic Nanoparticle Hyperthermia As An Adjuvant Cancer Therapy With Chemotherapy
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Author : Alicia Ailie Petryk
language : en
Publisher:
Release Date : 2013
Magnetic Nanoparticle Hyperthermia As An Adjuvant Cancer Therapy With Chemotherapy written by Alicia Ailie Petryk and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Magnetic nanoparticle-based hyperthermia for cancer treatment is a promising technology, particularly when applied as part of an adjuvant strategy with established cancer therapies (chemotherapy, radiation and surgery). In Europe, early clinical trials are being done using magnetic nanoparticle hyperthermia. The studies presented within this thesis examine several different aspects of the use of magnetic nanoparticles in hyperthermia therapies, particularly as an adjuvant treatment strategy with the chemotherapy cisplatinum. Magnetic nanoparticle (mNP) hyperthermia and microwave (915MHz) based hyperthermia were compared for treatment efficacy using induced murine flank tumors. Treatments were evaluated for normal tissue effects, cytotoxicity and resulting therapeutic ratio. In the case of the microwave comparison, mNPH demonstrated an improvement in treatment efficacy, although below statistical significance. However, there was less normal tissue damage with the mNP therapy. When examined as an adjuvant therapy with cisplatinum, it was determined that there is an enhancement of chemotherapy based therapeutic effect, when combined with magnetic nanoparticle hyperthermia. The importance of nanoparticle incubation, which results in changes in nanopartlcle distribution and cellular uptake, was also investigated. Optimization of nanoparticle distribution is essential for creating controlled and effective treatments. These studies indicated that when nanoparticles were allowed to incubate within the tumors of mice, the heating rate of the mNP was decreased. However, the tumor regrowth delay was similar to that seen with immediately activated nanoparticles. This was true both with and without cisplatinum adjuvant therapy. Systemically delivered nanoparticles for the treatment of metastatic cancer is also an attractive therapeutic approach. Cell pellets of different volumes were utilized to determine if cytotoxicity could be achieved with intracellular nanoparticles alone. Results indicate that a minimum number of cells/thermal mass is necessary to achieve intracellular nanoparticle based cytotoxic hyperthermia. In vivo, the use of cisplatinum to modify the tumor environment was investigated as a means to improve the nanoparticle concentration within the tumor. After pretreatment with cisplatinum, nanoparticle concentrations within the tumor increased as much as 3.1 times.
Hyperthermia In Cancer Treatment A Primer
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Author : Gian F. Baronzio
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-05-08
Hyperthermia In Cancer Treatment A Primer written by Gian F. Baronzio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-08 with Medical categories.
Following an introductory overview, Hyperthermia In Cancer Treatment: A Primer comprehensively describes the biological reasons for associating hyperthermia with radiation and chemotherapy and the biological and clinical effects of hyperthermia on cancerous and normal tissues. The volume’s 20 chapters are arranged in three principal parts: physical and methodological studies, biologic principles, and clinical studies.
Oncothermia Principles And Practices
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Author : Andras Szasz
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-11-23
Oncothermia Principles And Practices written by Andras Szasz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-23 with Medical categories.
Oncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option. This book is the first attempt to elucidate the theory and practice of oncothermia, based on rigorous mathematical and biophysical analysis, not centered on the temperature increase. It is supported by numerous in-vitro and in-vivo findings and twenty years of clinical experience. This book will help scientists, researchers and medical practitioners in understanding the scientific and conceptual underpinnings of oncothermia and will add another valuable tool in the fight against cancer. Professor Andras Szasz is the inventor of oncothermia and the Head of St Istvan University's Biotechnics Department in Hungary. He has published over 300 papers and lectured at various universities around the world. Dr. Oliver Szasz is the managing director of Oncotherm, the global manufacturer and distributor of medical devices for cancer treatment used in Europe & Asia since the late 1980s. Dr. Nora Szasz is currently a management consultant in healthcare for McKinsey & Co.
Magnetic Nanoparticles In Human Health And Medicine
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Author : Costica Caizer
language : en
Publisher: John Wiley & Sons
Release Date : 2021-09-08
Magnetic Nanoparticles In Human Health And Medicine written by Costica Caizer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-08 with Science categories.
Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer therapeutics—featuring discussion of current problems, proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.
Magnetic Nanoparticles In Biosensing And Medicine
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Author : Nicholas J. Darton
language : en
Publisher: Cambridge University Press
Release Date : 2019-02-14
Magnetic Nanoparticles In Biosensing And Medicine written by Nicholas J. Darton and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-14 with Medical categories.
Drawing together topics from a wide range of disciplines, and featuring up-to-date examples of clinical usage and research applications, this text provides a comprehensive insight into the fundamentals of magnetic biosensors and the applications of magnetic nanoparticles in medicine.
Polymeric And Natural Composites
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Author : Md Saquib Hasnain
language : en
Publisher: Springer Nature
Release Date : 2021-07-14
Polymeric And Natural Composites written by Md Saquib Hasnain and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-14 with Technology & Engineering categories.
This book provides understanding of raw materials, manufacturing and biomedical applications of different polymeric and natural composites such as drug delivery, growth factor delivery, orthopedics, dentistry and wound dressing.
Computational Science Iccs 2022
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Author : Derek Groen
language : en
Publisher: Springer Nature
Release Date : 2022-06-21
Computational Science Iccs 2022 written by Derek Groen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-21 with Computers categories.
The four-volume set LNCS 13350, 13351, 13352, and 13353 constitutes the proceedings of the 22ndt International Conference on Computational Science, ICCS 2022, held in London, UK, in June 2022.* The total of 175 full papers and 78 short papers presented in this book set were carefully reviewed and selected from 474 submissions. 169 full and 36 short papers were accepted to the main track; 120 full and 42 short papers were accepted to the workshops/ thematic tracks. *The conference was held in a hybrid format
Nanotheranostics
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Author : Mahendra Rai
language : en
Publisher: Springer Nature
Release Date : 2019-11-22
Nanotheranostics written by Mahendra Rai and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-22 with Medical categories.
This book is specifically designed to provide information about various nanocarriers currently developed under the emerging field of nanotheranostics for a sustained, controlled, and targeted co-delivery of diagnostic and therapeutic agents. Diverse theranostic applications of nanotechnology and their limitations are also addressed. It integrates nanobiotechnology with theranostic applications. The combined term nanotheranostics has diverse application particularly in chemotherapy and other infectious diseases.Among other topics addressed are antimicrobial resistance, targeting intra-cellular pathogens, viruses and bacteria, chemotherapy, cancer therapeutics, and inflammatory disorders. This interdisciplinary volume is essential for a diverse group of readers including nanotechnologists, microbiologists, biotechnologists, bioengineering and bioprocess industry.
Magnetic Fluid Hyperthermia
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Author : Ulrich Engelmann
language : en
Publisher:
Release Date : 2019-03-07
Magnetic Fluid Hyperthermia written by Ulrich Engelmann and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-07 with categories.
Magnetic fluid hyperthermia (MFH) uses magnetic nanoparticles (MNP) to transform the energy of an alternating magnetic field into heat via magnetic relaxation. This enables organ-confined cancer treatment by delivering cell-damaging temperatures higher than 43°C inside tumors. However, MNP-cell interaction restricts MNP mobility and causes MNP agglomeration, severely limiting the MNP heating behavior. Based on in vitro experiments, this book addresses the applicability of MFH to pancreatic tumor cells and discusses optimizations of intracellular MNP heating for clinical application. The impact of MNP-cell interaction on heating efficiency is quantified and compared to MNP systems mimicking intracellular conditions. Besides, Monte-Carlo simulation of MNP magnetic relaxation is used to predict optimal field parameters and MNP properties to maximize MFH efficiency under medical constraints.