Indole
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The Chemistry Of Indoles
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Author : Richard Sundberg
language : en
Publisher: Elsevier
Release Date : 2012-12-02
The Chemistry Of Indoles written by Richard Sundberg and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Organic Chemistry, Volume 18: The Chemistry of Indoles discusses the chemistry of indole derivatives. This book explores the potent biological activity of several indole derivatives and explains the structure of indole alkaloids. Organized into 10 chapters, this monograph starts with an overview of the most important types of reactions of the indole ring on a mechanical basis. This text then proceeds to review the methods of synthesizing indoles and describes the oxidations and rearrangements of indole derivatives. Other chapters explore the special features of the synthesis and reactivity of hydroxyindoles, acylindoles, and aminoindoles. This book discusses as well the properties of carboxyl groups, which is substituted on the benzenoid ring of the indole nucleus that is typical of aromatic carboxylic acids. The final chapter deals with the certain classes of indoles that are found in nature. Chemists, researchers, and readers interested in the chemistry of indoles will find this book extremely useful.
Indoles
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Author : Richard J. Sundberg
language : en
Publisher: Elsevier
Release Date : 1996-05-28
Indoles written by Richard J. Sundberg and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-05-28 with Science categories.
Indoles continue to be of great interest to the pharmaceutical industry and at the current time several thousand specific new derivatives are reported annually. Research has been driven by the wide range of indole derivatives which occur in nature and through the biological activity of many indole derivatives, of both natural and synthetic origin.This book provides a systematic guide to the most useful and important reactions in the field for both synthesis and synthetic modification of the indole ring. While including the most recently developed and promising methods, it also updates informationavailable on classical methods to give the reader an up-to-date and comprehensive view of the subject. The methods are illustrated by procedures drawn from the literature and by tables including examples chosen to indicate both the scope of applicabilityand variations in methodology. The organization of the book is based on the retrosynthetic concept of identifying the bond(s) formed in the reaction, which in turn identifies potential starting materials. Includes systematic summaries of the most important methods for the construction of indoles from aromatic precursors Discusses methods for preparing indoles by annelation of pyrroles Covers methods for adding or modifying substituent groups, including methods for introducing the tryptamine and tryptophan side-chainsExamines reduction/oxidation reactions that are specific for indoles Considers use of cycloaddition reactions for synthetic elaboration of indoles
Indole Ring Synthesis
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Author : Gordon W. Gribble
language : en
Publisher: John Wiley & Sons
Release Date : 2016-08-08
Indole Ring Synthesis written by Gordon W. Gribble and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-08 with Science categories.
Of the myriad of heterocycles known to man, the indole ring stands foremost for its remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in the terrestrial and marine environments. The indole ring continues to be discovered in natural products and to be employed in man-made pharmaceuticals and other materials. Given the enormous resurgence in indole ring synthesis over the past decade — highlighted by the power of transition metal catalysis — this authoritative guide addresses the need for a comprehensive presentation of the myriad of methods for constructing the indole ring, from the ancient to the modern, and from the obscure to the well-known. Following presentation of the classic indole ring syntheses and many newer methods, coverage continues with indole ring syntheses via pyrroles, indolines, oxindoles, isatins, radical and photochemical reactions, aryne cycloadditions. This extensive volume concludes with the modern transition metal–catalyzed indole ring syntheses that utilize copper, palladium, rhodium, gold, ruthenium, platinum, and other metals to fashion the indole ring Indole Ring Synthesis is a comprehensive, authoritative and up-to-date guide to the synthesis of this important heterocycle for organic chemists, pharmaceutical researchers and those interested in the chemistry of natural products.
Indole
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Author : Bridget Pratt
language : en
Publisher:
Release Date : 2019-03-12
Indole written by Bridget Pratt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-12 with categories.
In the foremost chapter of Indole: Synthesis, Functions and Reactions, derivatives of hydrogenated pyrido[4,3-b]indoles as potential neuroprotectors have been synthesized. Different substituents were introduced into position 8 of the carboline fragment of the molecule: methyl-, methoxy-, fluorine- and chlorine-ones. Biological tests have shown that all the studied compounds can modulate glutamate-dependent uptake of calcium ions in rats cerebral cortex synaptosomes. The authors go on to discuss how mushrooms and their mycelia from in vitro cultures have become increasingly common study subjects due to their health-promoting potential. The most frequently demonstrated properties of these mushrooms include antioxidative, anticancer, anti-inflammatory, immunostimulatory and anti-depressive effects. This activity stems from numerous mushroom metabolites, bioelements and physiologically active substances, including indole compounds. The final chapter provides an overview of the diverse synthetic approaches to generate pyrimido[4,5-b]indoles. Pyrimido-indoles are tricyclic ring systems produced when an indole group is fused with a pyrimidine ring. Of the two possible isomers of this ring system, the pyrimido[4,5-b]indoles are of particular interest relative to pyrimido[5,4-b]indoles due to their presence in a wide range of pharmacologically active molecules.
Indoles Volume 25 Part 4
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Author : J. Edwin Saxton
language : en
Publisher: John Wiley & Sons
Release Date : 2009-09-15
Indoles Volume 25 Part 4 written by J. Edwin Saxton and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-15 with Science categories.
Internationally renowned specialists present a comprehensive survey of the latest advances in this area. The biosynthetic and structural relationships of these compounds are summarized and newly discovered alkaloids described. Discusses versatile biomimetic procedures as well as the pharmacology and clinical applications of monoterpenoid indole alkaloids. Botanical names of all plants cited have been extensively referenced.
Synthetic Methods Of Indole Derivatives Named Reactions Used In The Synthesis Of Indole Derivatives
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Author : Kuldeep Singh
language : en
Publisher: Notion Press
Release Date :
Synthetic Methods Of Indole Derivatives Named Reactions Used In The Synthesis Of Indole Derivatives written by Kuldeep Singh and has been published by Notion Press this book supported file pdf, txt, epub, kindle and other format this book has been release on with Education categories.
Indole is the foremost heterocyclic compound in the entire heterocyclic system. Some of the ring heterocyclics are formed when the benzene ring is fused to five or six-membered heterocyclic compounds at the second and third positions of the benzene ring. It may include indole, benzofuran, quinoline, isoquinoline. Indole plays an integral role in chemical, biological and pharmacological activities. Indole nuclei carry immense importance as it built proteins in the form of amino acid tryptophan and depicts the Skelton of indole alkaloids. Indole binds with high affinity with the multiple receptors. Due to its huge medical importance such as antimicrobial, antiproliferative, antiviral, antifungal, antioxidant, antidiabetic, antihistamine, anti-inflammatory, analgesic, anticancer, antitubercular, antihypertensive, antimalarial, anticholinesterase and many more indole is found to be invariably crucial to study. The medical importance of indole amuses researchers to synthesize diverse types of indole derivatives as it also flair some new therapeutic effects. Indole moiety is a subpart of radical scavengers are found commonly in the body. Indole not only has biological importance but also acquires so many industrial applications say dyes, flavor enhancers, agriculture etc. It also has a significant role in commodity markets.
Indoles
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Author : Richard J. Sundberg
language : en
Publisher: Academic Press
Release Date : 1996-07-16
Indoles written by Richard J. Sundberg and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-07-16 with Science categories.
Indoles continue to be of great interest to the pharmaceutical industry and at the current time several thousand specific new derivatives are reported annually. Research has been driven by the wide range of indole derivatives which occur in nature and through the biological activity of many indole derivatives, of both natural and synthetic origin.This book provides a systematic guide to the most useful and important reactions in the field for both synthesis and synthetic modification of the indole ring. While including the most recently developed and promising methods, it also updates informationavailable on classical methods to give the reader an up-to-date and comprehensive view of the subject. The methods are illustrated by procedures drawn from the literature and by tables including examples chosen to indicate both the scope of applicabilityand variations in methodology. The organization of the book is based on the retrosynthetic concept of identifying the bond(s) formed in the reaction, which in turn identifies potential starting materials. Includes systematic summaries of the most important methods for the construction of indoles from aromatic precursors Discusses methods for preparing indoles by annelation of pyrroles Covers methods for adding or modifying substituent groups, including methods for introducing the tryptamine and tryptophan side-chainsExamines reduction/oxidation reactions that are specific for indoles Considers use of cycloaddition reactions for synthetic elaboration of indoles
Indole Alkaloids
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Author : W. I. Taylor
language : en
Publisher: Elsevier
Release Date : 2013-09-17
Indole Alkaloids written by W. I. Taylor and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-17 with Science categories.
A Course in Organic Chemistry Advanced Section, Volume 27: Indole Alkaloids: An Introduction to the Enamine Chemistry of Natural Products describes the chemistry of selected alkaloids that contain indolic or closely related nuclei. Some five hundred of these compounds have been obtained from about three hundred plants mostly of the family Apocynaceae. This book is composed of 12 chapters that specifically cover the chemistry of the complex indoles. The introductory chapters deal with the origin, isolation, characterization, basic chemistry, and simple derivatives of indole alkaloids. The remaining chapters examine the biogenesis, basic chemistry, stereochemistry, and structure of selected complex alkaloids of various origins. These chapters include tetrahydro-?-carboline, strychnos, iboga, picralima, and eburnamine alkaloids, cinchonamine, quinamine, and ajmaline-sarpagine bases. This text is of great value to organic chemists and researchers.
Indoles Volume 25 Part 2
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Author : William J. Houlihan
language : en
Publisher: John Wiley & Sons
Release Date : 2009-09-15
Indoles Volume 25 Part 2 written by William J. Houlihan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-15 with Science categories.
The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects – properties, synthesis, reactions, physiological and industrial significance – of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.
Indoles
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Author : William Joseph Houlihan
language : en
Publisher:
Release Date : 1971
Indoles written by William Joseph Houlihan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1971 with Indole categories.