Synthetic Methods Of Indole Derivatives Named Reactions Used In The Synthesis Of Indole Derivatives
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Synthetic Methods Of Indole Derivatives Named Reactions Used In The Synthesis Of Indole Derivatives
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Author : Kuldeep Singh
language : en
Publisher: Notion Press
Release Date :
Synthetic Methods Of Indole Derivatives Named Reactions Used In The Synthesis Of Indole Derivatives written by Kuldeep Singh and has been published by Notion Press this book supported file pdf, txt, epub, kindle and other format this book has been release on with Education categories.
Indole is the foremost heterocyclic compound in the entire heterocyclic system. Some of the ring heterocyclics are formed when the benzene ring is fused to five or six-membered heterocyclic compounds at the second and third positions of the benzene ring. It may include indole, benzofuran, quinoline, isoquinoline. Indole plays an integral role in chemical, biological and pharmacological activities. Indole nuclei carry immense importance as it built proteins in the form of amino acid tryptophan and depicts the Skelton of indole alkaloids. Indole binds with high affinity with the multiple receptors. Due to its huge medical importance such as antimicrobial, antiproliferative, antiviral, antifungal, antioxidant, antidiabetic, antihistamine, anti-inflammatory, analgesic, anticancer, antitubercular, antihypertensive, antimalarial, anticholinesterase and many more indole is found to be invariably crucial to study. The medical importance of indole amuses researchers to synthesize diverse types of indole derivatives as it also flair some new therapeutic effects. Indole moiety is a subpart of radical scavengers are found commonly in the body. Indole not only has biological importance but also acquires so many industrial applications say dyes, flavor enhancers, agriculture etc. It also has a significant role in commodity markets.
Indoles
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Author : Richard J. Sundberg
language : en
Publisher: Academic Press
Release Date : 1996-07-16
Indoles written by Richard J. Sundberg and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-07-16 with Science categories.
Indoles continue to be of great interest to the pharmaceutical industry and at the current time several thousand specific new derivatives are reported annually. Research has been driven by the wide range of indole derivatives which occur in nature and through the biological activity of many indole derivatives, of both natural and synthetic origin.This book provides a systematic guide to the most useful and important reactions in the field for both synthesis and synthetic modification of the indole ring. While including the most recently developed and promising methods, it also updates informationavailable on classical methods to give the reader an up-to-date and comprehensive view of the subject. The methods are illustrated by procedures drawn from the literature and by tables including examples chosen to indicate both the scope of applicabilityand variations in methodology. The organization of the book is based on the retrosynthetic concept of identifying the bond(s) formed in the reaction, which in turn identifies potential starting materials. Includes systematic summaries of the most important methods for the construction of indoles from aromatic precursors Discusses methods for preparing indoles by annelation of pyrroles Covers methods for adding or modifying substituent groups, including methods for introducing the tryptamine and tryptophan side-chainsExamines reduction/oxidation reactions that are specific for indoles Considers use of cycloaddition reactions for synthetic elaboration of indoles
Indoles
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Author : Richard J. Sundberg
language : en
Publisher: Elsevier
Release Date : 1996-05-28
Indoles written by Richard J. Sundberg and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-05-28 with Science categories.
Indoles continue to be of great interest to the pharmaceutical industry and at the current time several thousand specific new derivatives are reported annually. Research has been driven by the wide range of indole derivatives which occur in nature and through the biological activity of many indole derivatives, of both natural and synthetic origin.This book provides a systematic guide to the most useful and important reactions in the field for both synthesis and synthetic modification of the indole ring. While including the most recently developed and promising methods, it also updates informationavailable on classical methods to give the reader an up-to-date and comprehensive view of the subject. The methods are illustrated by procedures drawn from the literature and by tables including examples chosen to indicate both the scope of applicabilityand variations in methodology. The organization of the book is based on the retrosynthetic concept of identifying the bond(s) formed in the reaction, which in turn identifies potential starting materials. Includes systematic summaries of the most important methods for the construction of indoles from aromatic precursors Discusses methods for preparing indoles by annelation of pyrroles Covers methods for adding or modifying substituent groups, including methods for introducing the tryptamine and tryptophan side-chainsExamines reduction/oxidation reactions that are specific for indoles Considers use of cycloaddition reactions for synthetic elaboration of indoles
The Chemistry Of Indoles
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Author : Richard Sundberg
language : en
Publisher: Elsevier
Release Date : 2012-12-02
The Chemistry Of Indoles written by Richard Sundberg and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Organic Chemistry, Volume 18: The Chemistry of Indoles discusses the chemistry of indole derivatives. This book explores the potent biological activity of several indole derivatives and explains the structure of indole alkaloids. Organized into 10 chapters, this monograph starts with an overview of the most important types of reactions of the indole ring on a mechanical basis. This text then proceeds to review the methods of synthesizing indoles and describes the oxidations and rearrangements of indole derivatives. Other chapters explore the special features of the synthesis and reactivity of hydroxyindoles, acylindoles, and aminoindoles. This book discusses as well the properties of carboxyl groups, which is substituted on the benzenoid ring of the indole nucleus that is typical of aromatic carboxylic acids. The final chapter deals with the certain classes of indoles that are found in nature. Chemists, researchers, and readers interested in the chemistry of indoles will find this book extremely useful.
Synthesis Of Derivatized Indoles By Photocatalyzed Reactions In Batch And Microreactors
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Author : Helena Simek Tosino
language : en
Publisher: Logos Verlag Berlin GmbH
Release Date : 2024-06-03
Synthesis Of Derivatized Indoles By Photocatalyzed Reactions In Batch And Microreactors written by Helena Simek Tosino and has been published by Logos Verlag Berlin GmbH this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-03 with Science categories.
This work investigated a novel photochemical cyclization to form indole derivatives from o-alkynylated F-tagged aniline derivatives, and wide applicability to synthesize differently functionalized indole systems bearing various substituents in the positions N-1, C-2, C-3, C-5 and C-6 was shown. Additionally, this reaction was systematically studied in a kinetic study in an in-house assembled capillary photo-microreactor. Further derivatization of the final F-tagged 3-acylindoles by the cleavage of the perfluorinated chain yielded a library of novel indole-3-carboxylic acid and indole-3-carboxylic acid ester derivatives. A straightforward and efficient four-step methodology for the synthesis of desired indole derivatives with high yields for single steps and the whole sequence was developed. Variing the conditions of single steps showed that all three steps of the reaction route to the cyclization precursors can be performed using the same solvent and base, providing the possibility to conduct this sequence as a continuous-flow without the need for in-line solvent switch or base exchange and without compromises with respect to the selectivity and yields of single steps.
Visible Light Driven Fused Indole Synthesis
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Author : Chandra Sekhar
language : en
Publisher: Mohammed Abdul Malik
Release Date : 2024-03
Visible Light Driven Fused Indole Synthesis written by Chandra Sekhar and has been published by Mohammed Abdul Malik this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03 with Science categories.
Visible Light-Driven Fused Indole Synthesis, authored by Chandra Sekhar, is a comprehensive guide on the photochemical construction of fused indole frameworks using visible light photocatalysis. The book covers a wide range of topics related to organic chemistry, including synthetic methods, catalysis, green chemistry, organic photochemistry, and reaction mechanisms. One of the key focuses of the book is the synthesis of heterocyclic compounds, specifically indole derivatives, using visible light-driven photocatalysis. The author explains how this method of synthesis enables the use of sustainable chemistry, and offers a greener and more efficient alternative to traditional methods of chemical synthesis. The book delves into the molecular design and organic functionalization of various organic compounds, exploring the role of Lewis acids, photoredox catalysts, and other chemical intermediates in the process. It also covers the various energy transfer mechanisms involved in the process of photoactivation, and the use of carbonyl compounds and redox reactions in organic transformation. Additionally, the book explores the synthesis of aromatic compounds and N-heterocycles, and their potential use in the discovery of natural products and alkaloids. It also covers the excited state chemistry of organic materials, cascade reactions, and enantioselective synthesis using organic substrates. Overall, Visible Light-Driven Fused Indole Synthesis provides a valuable resource for researchers, students, and professionals in the field of synthetic organic chemistry, offering insight into the latest advances and techniques in the field.
Synthesis Of Indole Derivatives And Allied Compounds And Their Connection With Naturally Occurring Products
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Author : Kenneth Guy Blaikie
language : en
Publisher:
Release Date : 1923
Synthesis Of Indole Derivatives And Allied Compounds And Their Connection With Naturally Occurring Products written by Kenneth Guy Blaikie and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1923 with categories.
Indole
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Author : Bridget Pratt
language : en
Publisher:
Release Date : 2019-03-12
Indole written by Bridget Pratt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-12 with categories.
In the foremost chapter of Indole: Synthesis, Functions and Reactions, derivatives of hydrogenated pyrido[4,3-b]indoles as potential neuroprotectors have been synthesized. Different substituents were introduced into position 8 of the carboline fragment of the molecule: methyl-, methoxy-, fluorine- and chlorine-ones. Biological tests have shown that all the studied compounds can modulate glutamate-dependent uptake of calcium ions in rats cerebral cortex synaptosomes. The authors go on to discuss how mushrooms and their mycelia from in vitro cultures have become increasingly common study subjects due to their health-promoting potential. The most frequently demonstrated properties of these mushrooms include antioxidative, anticancer, anti-inflammatory, immunostimulatory and anti-depressive effects. This activity stems from numerous mushroom metabolites, bioelements and physiologically active substances, including indole compounds. The final chapter provides an overview of the diverse synthetic approaches to generate pyrimido[4,5-b]indoles. Pyrimido-indoles are tricyclic ring systems produced when an indole group is fused with a pyrimidine ring. Of the two possible isomers of this ring system, the pyrimido[4,5-b]indoles are of particular interest relative to pyrimido[5,4-b]indoles due to their presence in a wide range of pharmacologically active molecules.
Synthesis Of Indole Derivatives
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Author : Kathleen Marie Griego
language : en
Publisher:
Release Date : 1973
Synthesis Of Indole Derivatives written by Kathleen Marie Griego and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1973 with Clinical chemistry categories.
Name Reactions In Heterocyclic Chemistry
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Author : Jie Jack Li
language : en
Publisher: Wiley-Interscience
Release Date : 2004-12-27
Name Reactions In Heterocyclic Chemistry written by Jie Jack Li and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-12-27 with Science categories.
Covers important name reactions relevant to heterocyclic chemistry The field of heterocyclic chemistry has long presented a special challenge for chemists. Because of the enormous amount and variety of information, it is often a difficult topic to cover for undergraduate and graduate chemistry students, even in simplified form. Yet the chemistry of heterocyclic compounds and methods for their synthesis form the bedrock of modern medicinal chemical and pharmaceutical research. Thus there is a great need for high quality, up-to-date, and authoritative books on heterocyclic synthesis helpful to both the professional research chemist as well as the advanced student. Name Reactions in Heterocyclic Chemistry provides a one-stop repository for this important field of organic chemistry. The primary topics include three- and four-membered heterocycles, five-membered heterocycles including indoles, furans, thiophenes, and oxazoles, six-membered heterocycles including quinolines, isoquinolines, and pyrimidines, and other heterocycles. Each name reaction is summarized in seven sections: Description Historical perspective Mechanism Variations and improvements Synthetic utility Experimental References Authored by a team of world-renowned contributors - some of whom have discovered the very reactions they describe - Name Reactions in Heterocyclic Chemistry represents a state-of-the-art resource for students and researchers alike.