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Inflammation And Stroke

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Inflammation And Stroke

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Author : Giora Z. Feuerstein
language : en
Publisher: Springer
Release Date : 2012-12-06

Inflammation And Stroke written by Giora Z. Feuerstein and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Stroke is a leading cause of death in developed countries. However, current therapeutic strategies for stroke have been largely unsuccessful. One possible explanation is that research and pharmacological management have focused on very early events in brain ischemia. New research has shown that brain ischemia and trauma elicit strong inflammatory reactions driven by both external and brain cells. The recognition of inflammation as a fundamental response to brain ischemia provides novel opportunities for new anti-inflammatory therapies. For the first time, an international body of researchers presents the latest findings about the cellular and humoral aspects of immune and inflammatory reactions in the brain. The work may have an impact on the treatment of neuroinjuries and ancillary brain diseases, and increase the understanding of the roles infections and immune reactions play in the brain milieu.

Neuroinflammation In Stroke

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Author : Ulrich Dirnagl
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17

Neuroinflammation In Stroke written by Ulrich Dirnagl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.

The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.

Inflammation And Stroke

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Author : Giora Z. Feuerstein
language : en
Publisher: Birkhauser Basel
Release Date : 2001

Inflammation And Stroke written by Giora Z. Feuerstein and has been published by Birkhauser Basel this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.

Neuroinflammation

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Author : Mario Di Napoli
language : en
Publisher:
Release Date : 2008

Neuroinflammation written by Mario Di Napoli and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Cerebral ischemia categories.

Ischemic stroke is a devastating clinical event. Increasing evidence suggests that inflammatory mechanisms are involved in the progression of post ischemic-induced brain injury. Cerebral ischemia is accompanied by a marked inflammatory reaction that is initiated by ischemia-induced expression of cytokines, adhesion molecules, and other inflammatory mediators, including prostanoids, extracellular proteases, reactive oxygen species and nitric oxide, leading to the accumulation of inflammatory cells, such as leukocytes and microglia. The inflammatory reaction, which has a rapid onset and continues after the stroke, is thought to acutely contribute to the evolution of tissue injury. Many compounds have been identified in cerebral ischemia, which are known to promote and sustain inflammatory responses. Better understanding of the role of the post ischemic-induced inflammatory response and its potential for modulation might have profound implications for patient treatment. Pre-clinical studies suggest that interventions that are aimed at attenuating such inflammation reduce the progression of brain damage that occurs during the late stages of cerebral ischemia. In particular, strategies that block the activity of inflammation-related enzymes reduce ischemic damage with an extended therapeutic window. In this review, a summary of the available literature on the inflammatory responses after cerebral ischemia and ischemic stroke is presented along with discussion of some of the emerging opportunities for potential therapeutic strategies. Although at the moment, clinical trials using anti-inflammatory strategies did not show benefit in patients with ischemic stroke, there is a strong rationale for continuing to explore the efficacy of anti-inflammatory therapies in the treatment of the late stages of cerebral ischemia. It is plausible that in the near future, additional strategies using neuroprotective drug cocktails that target inflammation could offer exciting new promise in the therapeutic approach to ischemic stroke.

Immunological Mechanisms And Therapies In Brain Injuries And Stroke

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Author : Jun Chen
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-09

Immunological Mechanisms And Therapies In Brain Injuries And Stroke written by Jun Chen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-09 with Medical categories.

Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system. This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes.

Advancement In The Pathophysiology Of Cerebral Stroke

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Author : Ranjana Patnaik
language : en
Publisher: Springer
Release Date : 2019-05-13

Advancement In The Pathophysiology Of Cerebral Stroke written by Ranjana Patnaik and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-13 with Medical categories.

This book provides detailed and comprehensive mechanistic insights of the various risk factors that lead to the ischemic stroke and the novel therapeutic interventions against it. The first section discusses the different ischemic cerebral stroke-induced inflammatory pathways and dysfunctionality of blood-brain barrier. The later sections of the book deals with the role of endoplasmic reticulum stress and mitophagy in cerebral stroke and introduces the different neuroimaging techniques such as Computed tomography (CT), Magnetic resonance imaging (MRI), Positron emission tomography (PET) and Single-Photon emission computed tomography (SPECT) that are used to identify the arterial blockages. The final section comprises of chapters that focus on various neuroprotective strategies and emerging therapeutic interventions for combating stroke pathophysiology. The chapters cover the role of stem cell therapy, the therapeutic effect of low-frequency electromagnetic radiations (LF-EMR), and implications of non-coding RNAs such as micro-RNAs as the biomarkers for diagnosis, prognosis, and therapy in ischemic stroke.

Innate Inflammation And Stroke

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Author : Wolfgang Eisert
language : en
Publisher: Wiley-Blackwell
Release Date : 2010-11-08

Innate Inflammation And Stroke written by Wolfgang Eisert and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-08 with Medical categories.

This volume features contributions from both researchers and clinicians on innate inflammation in the central nervous system. The focus of the volume is on molecular and cellular mechanisms that are altered by innate inflammation and the translation to cerebrovascular risk. Also included are examinations of animal studies reflecting the pathophysiological consequences following acute or chronic ischemia with the reference to time course and level of innate inflammation as well as formation of reactive oxygen species of different kind. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Advancement In The Pathophysiology Of Cerebral Stroke

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Author : Ranjana Patnaik
language : en
Publisher:
Release Date : 2019

Advancement In The Pathophysiology Of Cerebral Stroke written by Ranjana Patnaik and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Cerebrovascular disease categories.

Hidden Causes Of Heart Attack And Stroke

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Author : Christian Wilde
language : en
Publisher:
Release Date : 2003-04

Hidden Causes Of Heart Attack And Stroke written by Christian Wilde and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-04 with Health & Fitness categories.

Written to empower you to interface intelligently with your doctors in protecting yourself and your family from America's number one killer. Written in everyday language, this book prepares you to discuss the cutting edge blood tests for C-reactive protein, inherited and acquired hidden risk factors and how to neutralize them by natural means. Rarely has a book drawn such enthusiastic endorsements from leaders in cardiology, even recommended for doctors. HEA000000

Experimental Stroke

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Author : Guo-Yuan Yang
language : en
Publisher:
Release Date : 2010-05-13

Experimental Stroke written by Guo-Yuan Yang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-13 with categories.

This book compiles the efforts of 20 experts in the field to review the latest advances in experimental stroke, with its strong emphasis on neurogenesis, angiogenesis and neuroprotection after cerebral ischemic stroke. It also provides current data for pharmacologic therapy, including anti-Inflammation, for stroke. Several chapters address cell death and apoptotsis after stroke as well as its replacement strategies by stem cells. Other chapters deal with the relation between stroke and neuroimmunology, BBB disruption and electrophysiological changes. Also covered is magnetic resonance imaging in ischemic brain. In a variety of preclinical models of stroke, pre-conditional and post-conditional stroke models will be discussed.

Inflammation And Stroke

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