Influence Of Radiotherapy And Tamoxifen On Contralateral Cancer Risk In Women With Hereditary Breast Cancer
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Influence Of Radiotherapy And Tamoxifen On Contralateral Cancer Risk In Women With Hereditary Breast Cancer
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Author : Mark Robson
language : en
Publisher:
Release Date : 2002
Influence Of Radiotherapy And Tamoxifen On Contralateral Cancer Risk In Women With Hereditary Breast Cancer written by Mark Robson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Women with breast cancer arising as a consequence of germline mutations in BRCA1 or BRCA2 are at significant risk of contralateral breast cancer (CBC). Examination of factors influencing contralateral risk will provide insight into prevention strategies for unaffected women with BRCA mutations. A combined analysis performed with the JGH indicates tamoxifen may reduce CBC risk by 53% (attached). To evaluate CBC risk factors, the funded study is assessing the impact of tamoxifen and radiotherapy on CBC risk. In the present funding period, in accordance with the Statement of Work, continued review of clinical records was performed, with identification of pathology blocks that will be cut to provide the samples for genotyping. Medical records from 1990 and 1991 were not reliably retrievable, leading us to expand the cohort eligibility dates to 199E. As of this report, we have reviewed 692 records in this interval, of whom 453 are eligible and for whom data has been entered. Data cleaning is in process and acquisition of tissue samples will begin shortly, followed by genotyping after anonymization. Combining these data with our original cohort of 329 cancers in 305 patients (JNCI 1999), we will have achieved 78% of our accrual goal of 1000 cases.
Influence Of Radiotherapy And Tamoxifen On Contralateral Cancer Risk In Women With Hereditary Breast Cancer
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Author :
language : en
Publisher:
Release Date : 2004
Influence Of Radiotherapy And Tamoxifen On Contralateral Cancer Risk In Women With Hereditary Breast Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Women with hereditary breast cancer are at high risk for contralateral breast cancer (CBC). To evaluate factors influencing CBC risk in women with BRCA mutations the funded study was designed to assess the impact of tamoxifen and radiotherapy on CBC. Records from a total of 874 Ashkenazi women with breast cancer diagnosed between 1990 and 1996 were reviewed to expand the initial cohort of 305 women treated between 1980 and 1990. Changes in medical record storage and HlPAA privacy regulations prevented the gathering of required basic clinical and/or follow-up information for an unacceptably large proportion of subjects. Because of the significant loss of patients to follow-up and lack of pathology material for genotyping alternative methods of attaining the study goals were sought. Specifically concatenation of the original 1980-1990 data-set with a similar ascertainment from another institution was performed and suggested a 53% contralateral risk reduction with adjuvant tamoxifen. A further 103 patients undergoing breast-conserving treatment were analyzed. This clinical ascertainment did not clearly support a benefit from tamoxifen (HR 0.71, 95% C.I. 0.23-2.2). However an expansion of the clinical ascertainment did suggest a benefit from tamoxifen (HR 0.37, 95% C.I 0.35) and no negative effect from radiation.
New Malignancies Among Cancer Survivors
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Author :
language : en
Publisher:
Release Date : 2006
New Malignancies Among Cancer Survivors written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Cancer categories.
Basic Radiation Oncology
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Author : Murat Beyzadeoglu
language : en
Publisher: Springer Nature
Release Date : 2022-01-01
Basic Radiation Oncology written by Murat Beyzadeoglu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-01 with Medical categories.
This practical, up-to-date, bedside-oriented radiation oncology book encompasses the essential aspects of the subject with coverage on radiation physics, radiobiology, and clinical radiation oncology. The first two sections examine concepts that are crucial in radiation physics and radiobiology. The third section describes radiation treatment regimens appropriate for the main cancer sites and tumor types.
Radiation Oncology
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Author : Gokhan Ozyigit
language : en
Publisher: Springer
Release Date : 2019-01-28
Radiation Oncology written by Gokhan Ozyigit and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-28 with Medical categories.
This book is an evidence-based guide to current use of radiation therapy for the treatment of malignancies at major disease sites. It is designed to meet the needs of residents, fellows, and practicing radiation oncologists and will assist in selection and delineation of tumor volumes/fields and dose prescription for intensity-modulated radiation therapy, including volumetric modulated arc therapy for stereotactic radiosurgery or stereotactic body radiotherapy. Each tumor site-related chapter presents, from the perspective of an academic expert, informative cases at different stages in order to clarify specific clinical concepts. The coverage includes case presentation, a case-related literature review, patient preparation, simulation, contouring, treatment planning, image-guided treatment delivery, follow-up, and toxicity management. The text is accompanied by illustrations ranging from slice-by-slice delineations on planning CT images to finalized plan evaluations based on detailed acceptance criteria. The expert knowledge and evidence contained in this comprehensive book will give readers the confidence to manage common cancers without outside referral and to meet the clinical challenges faced in everyday practice.
Hereditary Breast Cancer
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Author : Claudine Isaacs
language : en
Publisher: CRC Press
Release Date : 2019-08-30
Hereditary Breast Cancer written by Claudine Isaacs and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-30 with categories.
Intended for medical oncologists, surgeons, obstetricians, gynecologists, geneticists, genetic counselors, and primary care physicians, this text presents the epidemiological, biological, and clinical issues associated with hereditary breast cancer. It offers clear guidance on the application and utilization of cancer risk assessment models, genetic counseling and testing of high risk patients, and screening and prevention options for individuals at risk of hereditary breast cancer. Addressing every essential aspect of hereditary breast cancer, this source offers comprehensive analyses of hereditary breast cancer-associated syndromes, low penetrance genes, and hereditary breast cancer associated with mutations in the BRCA1 and BRCA2 genes.
Cancer And The Heart
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Author : Michael S. Ewer
language : en
Publisher: PMPH-USA
Release Date : 2013
Cancer And The Heart written by Michael S. Ewer and has been published by PMPH-USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Drugs categories.
The book begins with the basic science behind the medical applications of the knowledge: cardiovascular biology, pathways, and their relationship to cancer treatment and principles of chemotherapy and immunotherapy. The second section consists of an overview and classification of anti-cancer drugs and a look at their cardiotoxicity. The third section looks at cardiac imaging in the cancer patient, including cardiac ultrasound, Doppler imaging, nuclear imaging, magnetic resonance imaging, and computed tomography in the cancer patient. In section four, management of cardiac disease in the cancer patient is discussed, including cardiac rhythm disturbances and heart failure. Cardiac emergencies and interventions are described as is preoperative assessment of the cancer patient for non- cardiovascular surgery. The final section includes a range of topics such as the pericardium, cardiovascular effects of endocrine treatments, primary cardiac tumors and malignancies of the myocardium and pericardium. Cardiac monitoring during clinical trials and pulmonary concerns are also addressed, as are psychosocial, social, economic, and legal issues of the cancer patient with heart disease.
Breast Cancer In Young Women
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Author : Oreste Gentilini
language : en
Publisher: Springer Nature
Release Date : 2020-02-07
Breast Cancer In Young Women written by Oreste Gentilini and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-07 with Medical categories.
This contributed book covers all aspects concerning the clinical scenario of breast cancer in young women, providing physicians with the latest information on the topic. Young women are a special subset of patients whose care requires dedicated expertise. The book, written and edited by internationally recognized experts who have been directly involved in the international consensus guidelines for breast cancer in young women, pays particular attention to how the disease and its planned treatment can be effectively communicated to young patients. Highly informative and carefully structured, it provides both theoretical and practice-oriented insight for practitioners and professionals involved in the different phases of treatment, from diagnosis to intervention, to follow-up – without neglecting the important role played by prevention.
Absolute Clinical Radiation Oncology Review
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Author : Daniel M. Trifiletti
language : en
Publisher: Springer
Release Date : 2019-01-22
Absolute Clinical Radiation Oncology Review written by Daniel M. Trifiletti and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-22 with Medical categories.
This book provides a quick reference guide for clinicians in radiation oncology. It is designed to be an intuitive and easily reviewed study guide for board or maintenance of certification examinations, as well as a quick reference for residents and established radiation oncologists who need a refresher. The text begins with a general pearls chapter that radiation oncologists should consider in all aspects of their practice, including cancer visibility, dosing, counseling recommendations, and toxicity management. The subsequent chapters then delve into different cancer disease sites, including pediatrics, central nervous system, head and neck, thoracic, breast, gastrointestinal, gynecologic, genitourinary, hematologic, soft tissue, palliative, and radiophysics/radiobiology. Within each chapter, each disease and its recommended approach is then summarized in only a few pages, allowing a focus on the most essential information. Bullet points, figures, tables, and images make for an intuitive reader experience. Recommendations are taken from the American Society for Radiation Oncology (ASTRO), the European Society for Radiation Oncology (ESTRO), and the National Comprehensive Cancer Network (NCCN). Planning guides for imaging, diagnosis, and staging offer readers a starting point in approaching each patient based on disease origin, and dosing guidelines then detail consideration for treatment methods. Each chapter additionally includes disease-specific pearls and key points to test the knowledge reviewed in the chapters. Experts in the disease sites from the United States serve as senior authors on each chapter. The authors include all diseases associated with radiation oncology training to ensure a comprehensive resource for exam studying and clinical care. Residents, trainees, and established radiation oncologists find this an ideal study resource for both board and certification exams, as well as an easily accessible aid during practice.
Hereditary Breast Cancer
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Author : Claudine Isaacs
language : en
Publisher: CRC Press
Release Date : 2007-09-19
Hereditary Breast Cancer written by Claudine Isaacs and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-19 with Medical categories.
Intended for medical oncologists, surgeons, obstetricians, gynecologists, geneticists, genetic counselors, and primary care physicians, this text presents the epidemiological, biological, and clinical issues associated with hereditary breast cancer. It offers clear guidance on the application and utilization of cancer risk assessment models, geneti