Influence Of Stress On Cell Growth And Product Formation
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Influence Of Stress On Cell Growth And Product Formation
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Author : Karl Schügerl
language : en
Publisher: Springer
Release Date : 2003-06-30
Influence Of Stress On Cell Growth And Product Formation written by Karl Schügerl and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-06-30 with Science categories.
Stresses which arise in bioreactors can influence process performance considerably. Recent molecular biological investigations indicate that stress caused by fluid dynamical effects and extreme values of process variables and toxic substances cause similar responses in the cells. These molecular fundamentals, as well as quantitative evaluation of fluid dynamical stresses and, their effects on microorganisms, animal and plant cells and proteins are treated in this volume.
Cell And Tissue Reaction Engineering
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Author : Regine Eibl
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-09-30
Cell And Tissue Reaction Engineering written by Regine Eibl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-30 with Science categories.
The completion of the Human Genome Project and the rapid progress in cell bi- ogy and biochemical engineering, are major forces driving the steady increase of approved biotech products, especially biopharmaceuticals, in the market. Today mammalian cell products (“products from cells”), primarily monoclonals, cytokines, recombinant glycoproteins, and, increasingly, vaccines, dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells (“cells as product”) for regenerative medicine have also been introduced in the market. Their efficient production requires comprehensive knowledge of biological as well as biochemical mammalian cell culture fundamentals (e.g., cell characteristics and metabolism, cell line establishment, culture medium optimization) and related engineering principles (e.g., bioreactor design, process scale-up and optimization). In addition, new developments focusing on cell line development, animal-free c- ture media, disposables and the implications of changing processes (multi-purpo- facilities) have to be taken into account. While a number of excellent books treating the basic methods and applications of mammalian cell culture technology have been published, only little attention has been afforded to their engineering aspects. The aim of this book is to make a contribution to closing this gap; it particularly focuses on the interactions between biological and biochemical and engineering principles in processes derived from cell cultures. It is not intended to give a c- prehensive overview of the literature. This has been done extensively elsewhere.
Secondary Plant Products
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Author : E. E. Conn
language : en
Publisher: Academic Press
Release Date : 2013-10-22
Secondary Plant Products written by E. E. Conn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Science categories.
Approx.798 pages
Plant Biotechnology And Molecular Markers
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Author : S. Srivastava
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-01-16
Plant Biotechnology And Molecular Markers written by S. Srivastava and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-16 with Science categories.
The genesis of the volume, Plant Biotechnology and Molecular Markers, has been the occasion of the retirement of Professor Sant Saran Bhojwani from the Department of Botany, University of Delhi. For Professor Bhojwani, retirement only means relinquishing the chair as being a researcher and a teacher which has always been a way of life to him. Professor Bhojwani has been an ardent practitioner of modern plant biology and areas like Plant Biotechnology and Molecular Breeding have been close to his heart. The book contains original as well as review articles contributed by his admirers and associates who are experts in their area of research. While planning this contributory book our endeavour has been to incorporate articles that cover the entire gamut of Plant Biotechnology, and also applications of Molecular Markers. Besides articles on in vitro fertilization and micropropagation, there are articles on forest tree improvement through genetic engineering. Considering the importance of conservation of our precious natural wealth, one article deals with cryopreservation of plant material. Chapter on molecular marker considers DNA indexing as markers of clonal fidelity of in vitro regenerated plants and prevention against bio-piracy. A couple of write-ups also cover stage-specific gene markers, DNA polymorphism and genetic engineering, including raising of stress tolerant plants to sustain productivity and help in reclamation of degraded land.
Plant Tissue Culture Engineering
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Author : S. Dutta Gupta
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-07-10
Plant Tissue Culture Engineering written by S. Dutta Gupta and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-10 with Science categories.
It is my privilege to contribute the foreword for this unique volume entitled: “Plant Tissue Culture Engineering,” edited by S. Dutta Gupta and Y. Ibaraki. While there have been a number of volumes published regarding the basic methods and applications of plant tissue and cell culture technologies, and even considerable attention provided to bioreactor design, relatively little attention has been afforded to the engineering principles that have emerged as critical contributions to the commercial applications of plant biotechnologies. This volume, “Plant Tissue Culture Engineering,” signals a turning point: the recognition that this specialized field of plant science must be integrated with engineering principles in order to develop efficient, cost effective, and large scale applications of these technologies. I am most impressed with the organization of this volume, and the extensive list of chapters contributed by expert authors from around the world who are leading the emergence of this interdisciplinary enterprise. The editors are to be commended for their skilful crafting of this important volume. The first two parts provide the basic information that is relevant to the field as a whole, the following two parts elaborate on these principles, and the last part elaborates on specific technologies or applications.
Physiological Stress Responses In Bioprocesses
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Author : Sven-Olof Enfors
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-05-06
Physiological Stress Responses In Bioprocesses written by Sven-Olof Enfors and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-05-06 with Medical categories.
This review series covers trends in modern biotechnology. All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science, are treated. Electronic version available at http://link.springer.de/series/abe/
Bioreactors For Tissue Engineering
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Author : Julian Chaudhuri
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-01-16
Bioreactors For Tissue Engineering written by Julian Chaudhuri and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-16 with Medical categories.
For the first time in a single volume, the design, characterisation and operation of the bioreactor system in which the tissue is grown is detailed. Bioreactors for Tissue Engineering presents an overall picture of the current state of knowledge in the engineering of bioreactors for several tissue types (bone, cartilage, vascular), addresses the issue of mechanical conditioning of the tissue, and describes the use of techniques such as MRI for monitoring tissue growth. This unique volume is dedicated to the fundamentals and application of bioreactor technology to tissue engineering products. Not only will it appeal to graduate students and experienced researchers in tissue engineering and regenerative medicine, but also to tissue engineers and culture technologists, academic and industrial chemical engineers, biochemical engineers and cell biologists who wish to understand the criteria used to design and develop novel systems for tissue growth in vitro.
Handbook Of Marine Microalgae
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Author : Se-Kwon Kim
language : en
Publisher: Academic Press
Release Date : 2015-04-30
Handbook Of Marine Microalgae written by Se-Kwon Kim and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-30 with Science categories.
Handbook of Microalgae: Biotechnology Advances offers complete coverage of marine microalgae, including biology, production techniques, biotechnological applications, economic perspectives of applications, and environmental effects of marine microalgae blooms. With contributions from world experts, Handbook of Microalgae: Biotechnology Advances focuses on microalgae from an organism perspective to offer a complete picture from evolution to biofuel. Focuses on a comprehensive approach from an organism point of view Contains full coverage of all aspects of microalgae from biology through biotechnological and biomedical applications Includes biological properties of commercial algal species Provides microalgae screening and identification methods, culturing methods and new aspects of processing
Disposable Bioprocessing Systems
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Author : Sarfaraz K. Niazi
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Disposable Bioprocessing Systems written by Sarfaraz K. Niazi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Written by a researcher with experience designing, establishing, and validating biological manufacturing facilities worldwide, this is the first comprehensive introduction to disposable systems for biological drug manufacturing. It reviews the current state of the industry; tackles questions about safety, costs, regulations, and waste disposal; and guides readers to choose disposable components that meet their needs. This practical manual covers disposable containers, mixing systems, bioreactors, connectors and transfers, controls and sensors, downstream processing systems, filling and finishing systems, and filters. The author also shares his predictions for the future, calling disposable bioprocessing technology a "game changer."
Disposable Bioreactors
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Author : Regine Eibl
language : en
Publisher: Springer
Release Date : 2009-12-02
Disposable Bioreactors written by Regine Eibl and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-02 with Science categories.
Over the past five years, the immense financial pressure on the development and manufacturing of biopharmaceuticals has resulted in the increasing use and acce- ance of disposables, which are discarded after harvest and therefore intended only for single use. In fact, such disposables are implemented in all the main bioprocess production stages today and an even higher growth than those in the biopharmac- tical market is predicted (reaching double figures). Alongside disposable filter capsules, membrane chromatography units, tubing, connectors, flexible containers processing or containing fluids, freezer systems, mixers and pumps, and fully c- trolled disposable bioreactors of up to 2,000 L culture volume are already available on the market. Numerous studies highlight the advantages of disposable bioreactors and reveal their potential for simple, safe and fast seed inoculum production, process devel- ment and small as well as middle volume production (e.g. bioactive substances, viruses for vaccines and gene therapies etc.). They suggest that such disposable bioreactors (typically characterized by the cultivation chamber or bag from plastic materials) may be advantageous for plant, animal and microbial cells. Running industrial activities such as CFD-modelling, development of single-use process monitoring and control technology, and standardized film formulations are attempting to resolve the limitations of the current disposable bioreactors. These achievements, along with substantial improvements in product yield, will reduce the use of stainless steel in the biomanufacturing facilities of the future.