Innate Immune Regulation And Cancer Immunotherapy
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Innate Immune Regulation And Cancer Immunotherapy
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Author : Rong-Fu Wang
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-02-02
Innate Immune Regulation And Cancer Immunotherapy written by Rong-Fu Wang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-02 with Medical categories.
Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.
Innate Immune Regulation And Cancer Immunotherapy
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Author :
language : en
Publisher: Springer
Release Date : 2011-11-30
Innate Immune Regulation And Cancer Immunotherapy written by and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-30 with categories.
New Insights Into Innate Immune Cell Based Immunotherapies In Cancer
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Author : Mary Poupot-Marsan
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-17
New Insights Into Innate Immune Cell Based Immunotherapies In Cancer written by Mary Poupot-Marsan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-17 with Medical categories.
Tumor Immunology And Immunotherapy
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Author : Robert C. Rees
language : en
Publisher: Oxford University Press, USA
Release Date : 2014
Tumor Immunology And Immunotherapy written by Robert C. Rees and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Medical categories.
Tumor immunology and immunotherapy provides a comprehensive account of cancer immunity and immunotherapy. Examining recent results, current areas of interest and the specific issues that are affecting the research and development of vaccines, this book provides insight into how these problems may be overcome as viewed by leaders in the field.
Cancer Immunotherapy
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Author : Jenni Punt
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-06-04
Cancer Immunotherapy written by Jenni Punt and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-04 with Medical categories.
Once alerted by the innate immune system to the presence of a pathogen or a cellular abnormality, the adaptive immune system responds by activating and expanding antigen-specific B and T lymphocytes. This chapter focuses specifically on the activation and activities of T lymphocytes, which coordinate the adaptive immune response. We open with a description of where and how naïve T cells first encounter antigen. We then examine what factors influence the differentiation of helper CD4+ T lymphocytes into one of several effector subsets, each of which secretes a distinct subset of cytokines. We follow with a discussion of the origin and function of cytotoxic CD8+ T cells, the lymphocyte with the capacity to directly kill tumor cells. We close with a brief summary of the unique challenges that face the adaptive immune system when it tried to mount a response to a tumor.
Cancer Immunotherapy
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Author : Kenneth F. May
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-06-04
Cancer Immunotherapy written by Kenneth F. May and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-04 with Medical categories.
The interplay of innate and adaptive antitumor immunity dictates the intensity and outcome of the endogenous anticancer response. Stress-induced molecules on tumor cells trigger innate immune reactions, whereas the processing and presentation of tumor-associated antigens evokes adaptive immune recognition. Innate and adaptive antitumor responses may impact tumor development in different ways. In some cases, endogenous reactions suppress tumor formation, while exerting a selective pressure that fosters the emergence of escape variants. Alternatively, some host responses promote tumor cell growth, invasion, and metastasis through the elaboration of inflammatory mediators and cytokines. Investigations have uncovered unique and overlapping roles for innate and adaptive anti tumor immunity, revealing a complex network of interactions among tumor cells, immune elements, and stromal components within the tumor microenvironment, which together shape the direction, quality, and dynamics of the anticancer response.
Innate Immune Cell Therapy Of Cancer
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Author : Asha B. Pillai
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-13
Innate Immune Cell Therapy Of Cancer written by Asha B. Pillai and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-13 with Science categories.
Adoptive cellular immunotherapy of cancer, particularly chimeric antigen receptor-transduced T cell (CAR-T) therapies, have enjoyed an explosion of clinical trials and translational and basic research in the past decade. The concept and design of the CAR, though originally intended to optimize targeting of innate natural killer cells (NK cells) to tumor-specific antigens, was laterally applied in the past decade to conventional autologous and later third-party allogeneic T cells with first-in-kind successes in leukemia immunotherapy in both adults and children. This approach also spawned the development of an entire industry focused on cancer immunotherapy, laying the foundation for the current paradigm shifts away from toxic chemo/radiotherapy to immune targeting. Aside from cytokine-release toxicities, specific obstacles plaguing existing CAR-T cell therapies include suboptimal killing by fatigued or senescent autologous patient-derived T cells derived, acquisition of tumor resistance to T-cell based immune therapies, and graft-versus-host disease (GVHD) associated with allogeneic conventional T cell therapies.
Immunotherapy Of Cancer
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Author : Mary L. Disis
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-12-15
Immunotherapy Of Cancer written by Mary L. Disis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-15 with Medical categories.
Expert bench and clinical scientists join forces to concurrently review both the state-of-the-art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunologic monitoring-and the new advances and directions in cancer immunotherapy are also fully examined.
Inflammation And Immunity In Cancer
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Author : Tsukasa Seya
language : en
Publisher: Springer
Release Date : 2015-03-26
Inflammation And Immunity In Cancer written by Tsukasa Seya and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-26 with Medical categories.
This book overviews cancer immunity from broad scientific fields, based on the concept that cancer is a sort of by-product of infection, inflammation, and host immune response. The innate and acquired arms of the immune system mainly participate in tumor immune surveillance, and their activation is critically modulated by the situation of the tumor microenvironment. Many types of immune cells join the formation of the microenvironment. In particular, macrophages and dendritic cells enter the tumor mass to be main players in the inflammatory milieu of tumors. After introducing these topics, the book discusses immunotherapy for cancer patients as an outgrowth of this concept of infection and inflammation. With the contributions of leading scientists actively involved in the field of antitumor immunity study, this book encourages readers to understand the mechanism of general cancers based on inflammation and will facilitate prevention and the development of therapeutics for cancer.
Immunotherapy Of Cancer
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Author : Yoshiyuki Yamaguchi
language : en
Publisher: Springer
Release Date : 2016-02-22
Immunotherapy Of Cancer written by Yoshiyuki Yamaguchi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-22 with Medical categories.
This timely book, published just as cancer immunotherapy comes of age, summarizes the rationale, present status, and future perspective for cancer immunotherapy. Included are explanations of the constitution of the immune system and immunocheckpoints, the mechanism of antigen presentation and recognition, valuable modalities, clinical trials and guidance, personalization, and biomarkers, all of which are essential for understanding the success of cancer immunotherapy. This innovative therapy has been investigated worldwide as the fourth line of cancer treatment after the standard treatments of surgery, chemotherapy, and radiotherapy. The progress in fundamental understanding of tumor immunology and the recent advances in clinical trials have opened new avenues with a cancer vaccine in 2010 and immunocheckpoint modulation in 2011, with their approval already granted in the United States. Today, there are no doubts, even among experts in cancer chemotherapy and radiotherapy, that the immune system plays a vital role in tumor eradication. Following American approval, many clinical trials of cancer immunotherapy are being conducted. With this book the reader will readily understand the paradigm shift in cancer treatment and will realize the importance of cancer immunotherapy. The great value of immunotherapy will be obvious, not only for tumor shrinkage but for prolonging patient survival.