Insights In Cardiovascular And Smooth Muscle Pharmacology 2023
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Insights In Cardiovascular And Smooth Muscle Pharmacology 2023
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Author : Simon Lebek
language : en
Publisher: Frontiers Media SA
Release Date : 2025-01-17
Insights In Cardiovascular And Smooth Muscle Pharmacology 2023 written by Simon Lebek and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-17 with Science categories.
Cardiovascular diseases have evolved as the main cause of morbidity and mortality worldwide with the frequency expected to increase in the next coming years. Cardiovascular disease summarizes a variety of different pathologies, including but not limited to heart failure, atrial and ventricular arrhythmias, inherited cardiomyopathies, or toxic cardiomyopathy (e.g., alcoholic). Plus, the interaction with important comorbidities, like for example sleep-disordered breathing, further reduces patients’ outcome. Despite recent treatment advances, especially in heart failure patients with reduced ejection fraction, patients’ prognosis remains dramatically reduced, necessitating new therapeutic strategies. This could be achieved by patient-individualized approaches optimized for the various cardiovascular disease entities and their comorbidities. Therefore, detailed understanding of each individual pathomechanism is required.
Genetics Of Familial Hypercholesterolemia New Insight Volume Ii
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Author : Alpo Juhani Vuorio
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-04
Genetics Of Familial Hypercholesterolemia New Insight Volume Ii written by Alpo Juhani Vuorio and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-04 with Science categories.
Pain And Pain Related Neuropsychiatric Disorders From Mechanistic Insights To Innovative Therapeutic Strategies
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Author : Álvaro Llorente-Berzal
language : en
Publisher: Frontiers Media SA
Release Date : 2025-04-07
Pain And Pain Related Neuropsychiatric Disorders From Mechanistic Insights To Innovative Therapeutic Strategies written by Álvaro Llorente-Berzal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-07 with Science categories.
Chronic pain is an important personal and socio-economic burden, affecting more than 30% of people worldwide. It is highly disabling and associated with long-term affective and cognitive sequelae. Despite synergistic advances in basic and clinical research, some of the most severe conditions remain poorly managed, shifting from nociceptive nature to neuropathic and nociplastic components and major neuropsychiatric complications. Therefore, the understanding of pathophysiological mechanisms and the discovery of new pharmacological targets and innovative approaches are strongly awaited. Important advances in basic research focus on the mechanistic aspect, offering no direct implication for novel therapeutic strategies. Conversely, the use of innovative therapies is not easily considered in clinical practice, breaking the process of translation for therapy. The primary goal of this Research Topic is to create a synergistic circularity of knowledge, merging clinical challenges with the latest pathophysiological findings in the field of pain and related neuropsychiatric disorders, with implications for pharmacological innovation. In addition, with a view to sustainability, particular attention will be given to compounds of natural origin, from new cannabinoids, alkaloids, and capsaicinoids to tannins, flavonoids, and other substances or approaches.
Reviews In Cardiovascular Pharmacology 2023
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Author : Yusof Kamisah
language : en
Publisher: Frontiers Media SA
Release Date : 2025-02-27
Reviews In Cardiovascular Pharmacology 2023 written by Yusof Kamisah and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-27 with Science categories.
Cardiovascular diseases are a principal cause of death globally. Cardiovascular diseases include hypertension, atherosclerosis, ischemic heart disease, and heart failure which cause a hike in socioeconomic burden. The disorders can occur due to unhealthy lifestyle like smoking and high-fat diet, genetic, and age. Both experimental and clinical studies are in progress, in search for drugs with improved efficacy and lesser side effects. These studies and experimental research aim to develop novel cardiovascular drugs, many of which are used clinically to alleviate the symptoms and severity of the diseases. For instance, combined therapy of sacubitril/valsartan for patients with heart failure demonstrates better clinical outcomes than the use of valsartan alone. Moreover, recently, clinical indications of originally non-cardiovascular drugs such as sodium-glucose co-transporter-2 inhibitors (antidiabetic drugs) are repurposed for the treatment of cardiovascular diseases. Therefore, it is ultimately eminent for the research community to be updated with recent advances in cardiovascular pharmacotherapy. Reviews in Cardiovascular Pharmacology: 2023 will publish high-quality scholarly review papers on key topics in Cardiovascular Pharmacology. It aims to highlight recent progress in the field, whilst emphasizing important directions and new possibilities for future inquiries. We anticipate the research presented will promote discussion in the Cardiovascular Pharmacology community that will translate to best practice applications in clinical, public health and policy settings.
Insights In Vascular Physiology 2024
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Author : Christopher Garland
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-18
Insights In Vascular Physiology 2024 written by Christopher Garland and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-18 with Science categories.
We are now in the third decade of the 21st Century, and especially in recent years, scientists have made exceptional achievements, leading to major advancements in the fast-growing field of Vascular Physiology. This Frontiers Research Topic aims to highlight the latest advancements in vascular physiology and pathophysiology, including novel developments, current challenges, latest discoveries, recent advances, and future perspectives. It is edited by Topic Editors Prof. Irena Levitan (University of Illinois Chicago, USA), Prof. Christopher Garland (University of Oxford, UK) and Prof. Luis A. Martinez-Lemus (University of Missouri, USA). The Research Topic solicits forward-looking contributions from the editorial board members that describe the state of the art, outlining, recent developments and major accomplishments that have been achieved and that need to occur to move the field forward. Authors are encouraged to identify the greatest challenges in the sub-disciplines, and how to address those challenges. This article collection will inspire, inform and provide direction and guidance to researchers in the field.
The Mechanisms Of Fibrotic Disorders And Pharmacological Therapies
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Author : Yaying Sun
language : en
Publisher: Frontiers Media SA
Release Date : 2025-05-21
The Mechanisms Of Fibrotic Disorders And Pharmacological Therapies written by Yaying Sun and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-21 with Science categories.
Fibrosis, characterized by uncontrolled extracellular matrix deposition, is a common phenomenon seen in different organs and tissues, bringing about disastrous influence on the function. Fibrosis can be induced by aging and diseases, such as sarcopenia during aging, renal fibrosis following diabetes, liver fibrosis following non-alcohol fatty liver disease; can be elicited by trauma or surgery, such as shoulder stiffness and elbow stiffness; and can also be a feature of the tumor, in which is also known as epithelial-mesenchymal transition. Currently, anti-fibrosis therapies are investigated broadly, while the complexity of this condition retards the development of effect modalities remarkably. Therefore, a better understanding of the mechanisms of fibrosis-related disorders is of urgent need. Recent decades have witnessed remarkable advancement in multi-omic investigations and the progress of pharmacogenomics. Countless potential targets are unveiled by integrating the data of genomics and pharmacology. Since fibrosis and related disorders have various manifestations at the cellular level, proteomic level, and transcriptional level, integrative analysis is of vital importance in identifying targets. Moreover, the interplay between different cells in fibrotic tissue is also finely described by single-cell sequencing and spatial-transcriptome, et al, greatly broadening the understanding of the progress of fibrosis. Therefore, this research topic aims to study the underlying mechanisms of fibrosis and related diseases with specific attention to molecular targets. We welcome research revealing the mechanisms of fibrosis and studies to identify novel molecules against fibrogenesis.
Insights In Atherosclerosis And Vascular Medicine 2021
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Author : Masanori Aikawa
language : en
Publisher: Frontiers Media SA
Release Date : 2023-02-28
Insights In Atherosclerosis And Vascular Medicine 2021 written by Masanori Aikawa and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-28 with Medical categories.
Pharmacology For The Surgical Technologist E Book
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Author : Tiffany Howe
language : en
Publisher: Elsevier Health Sciences
Release Date : 2023-10-25
Pharmacology For The Surgical Technologist E Book written by Tiffany Howe and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-25 with Medical categories.
Learn pharmacology from the text designed specifically for surgical technologists! Pharmacology for the Surgical Technologist, 6th Edition prepares you to work in an operating room by providing an in-depth understanding of surgical medications. It covers everything a surgical technologist needs to know, including basic pharmacology, dosage calculations, safe handling of medications, terminology, and drug effects and side effects. For Surgical First Assistant courses, many chapters include coverage of advanced practice. Written by a surgical technology educator and a practicing surgical technologist, this book covers all areas of pharmacology and anesthesia that are designated in the AST Core Curriculum for Surgical Technology. - Pharmacology content is specifically tailored to meet the unique needs of the Surgical Technologist and includes all areas designated in the AST Core Curriculum for Surgical Technology. - Chapter study questions help you measure your knowledge and apply learning to practice, while also serving as a review tool for classroom and certification exams. - Advanced practice content, centering on issues specific to the Surgical First Assistant, provides you with information to help advance your career and keep this text as a professional reference. - Caution feature boxes focus attention on drug and surgical safety issues, while Insight boxes provide in-depth, cutting-edge information on specific products, procedures, and processes in the operating room. - Additional learning features include Tech Tips from experts, Notes that simplify difficult concepts, Quick Question boxes that quiz you on foundational knowledge, and Make It Simple boxes that review medical terminology. - Comprehensive glossary supports key terms highlighted throughout the text. - NEW! Content updates reflect the most recent version of the AST Core Curriculum for Surgical Technology, including new information on anesthesia, specifically patient monitoring devices, airway management, complications, and routes of administration. - NEW! Chapter review questions on the Evolve companion website offer extra opportunity for you to assess your knowledge.
Kaplan S Cardiac Anesthesia E Book
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Author : Joel A. Kaplan
language : en
Publisher: Elsevier Health Sciences
Release Date : 2023-06-09
Kaplan S Cardiac Anesthesia E Book written by Joel A. Kaplan and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-09 with Medical categories.
Current, comprehensive, and evidence-based, Kaplan's Cardiac Anesthesia: Perioperative and Critical Care Management, 8th Edition, offers practical guidance from today's international leaders in cardiac anesthesiology, helping you to optimize perioperative outcomes, avoid complications, and ensure maximum patient safety. Dr. Joel A. Kaplan, along with an expert team of associate editors, guides you through today's clinical challenges, including expanded coverage of critical care, the newest approaches to perioperative assessment and management, state-of-the art diagnostic techniques, and cardiovascular and coronary physiology. - Covers the full spectrum of contemporary cardiothoracic anesthesia practice, including preoperative assessment, physiology, pharmacology, monitoring, transesophageal echocardiography, coagulation, specific cardiac procedures, extracorporeal circulation, postoperative pain treatment, and management of the complex patient with cardiac disease. - Includes expanded coverage of critical care topics, reflecting the increased perioperative care now provided by anesthesiologists in the ICU. - Contains new chapters on Structural Heart Disease Procedures; Cardiorespiratory Effects of COVID-19; Critical Care Ultrasound; Intensive Unit Management of Patients on Mechanical Circulatory Support; and Postoperative Care of the Heart and Lung Transplant Patient. - Features more than 900 full-color illustrations, decision trees, charts, and graphs (over one-third are new) that aid in visual understanding of complex topics. - Provides access to over 120 videos, including a range of echocardiography clips. - Contains balanced, dependable, and updated content on all aspects of the anesthetic management of cardiac surgical procedures, as well as cardiology procedures performed in catheterization and electrophysiologic laboratories. - Places new emphasis on cardiac devices requiring perioperative care, including cardiac implanted electrical devices and ventricular assist devices. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Diabetes And Cardiovascular Disease New Therapeutic Interventions
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Author : Ludwig Weckbach
language : en
Publisher: Frontiers Media SA
Release Date : 2024-08-22
Diabetes And Cardiovascular Disease New Therapeutic Interventions written by Ludwig Weckbach and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-22 with Science categories.
Diabetes, also known as diabetes mellitus (DM), is a disease that occurs when the glucose level in the blood becomes too high (hyperglycaemia). Chronic hyperglycaemia is accompanied by both biochemical and pathological complications such as retinopathy, nephropathy, neuropathy, and cardiovascular diseases. Diabetes mellitus can be classified into two types: type I which results from the destruction of pancreatic β-cells, leading to insulin insufficiency and type II diabetes mellitus, which is mainly related to insulin resistance. Optimal control of blood glucose levels remains the cornerstone of managing DM. To date, the major classes of antidiabetic medications used to treat diabetes include: biguanides, dipeptidyl peptidase 4 (DPP-4) inhibitors, sulfonylureas, meglitinides, thiazolidinediones (TZDs), sodium-glucose cotransporter (SGLT2) inhibitors, α-glucosidase inhibitors, glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonists and the various types of insulin. Several of these drugs may have, besides their antidiabetic properties, also important cardiovascular complications for the patients taking them.