Integration Interaction Of Oncologic Growth
DOWNLOAD
Download Integration Interaction Of Oncologic Growth PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Integration Interaction Of Oncologic Growth book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Integration Interaction Of Oncologic Growth
DOWNLOAD
Author : Gary G. Meadows
language : en
Publisher: Springer
Release Date : 2009-09-03
Integration Interaction Of Oncologic Growth written by Gary G. Meadows and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-03 with Medical categories.
A unique book on the interactions and interrelationships between tumor and host that modulate progression and metastasis. Several authors emphasize targeting the host rather than the tumor itself for therapeutic intervention to control cancer.
Integration Interaction Of Oncologic Growth
DOWNLOAD
Author : Gary G. Meadows
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-11-10
Integration Interaction Of Oncologic Growth written by Gary G. Meadows and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-10 with Medical categories.
A unique book on the interactions and interrelationships between tumor and host that modulate progression and metastasis. Several authors emphasize targeting the host rather than the tumor itself for therapeutic intervention to control cancer.
Growth Factors And Their Receptors In Cell Differentiation Cancer And Cancer Therapy
DOWNLOAD
Author : G V Sherbet
language : en
Publisher: Elsevier
Release Date : 2011-07-12
Growth Factors And Their Receptors In Cell Differentiation Cancer And Cancer Therapy written by G V Sherbet and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-12 with Science categories.
Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes Aids the development of therapeutic treatments for cancer Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research
Drug Delivery In Oncology
DOWNLOAD
Author : Felix Kratz
language : en
Publisher: John Wiley & Sons
Release Date : 2013-09-30
Drug Delivery In Oncology written by Felix Kratz and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-30 with Medical categories.
In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.
Ketogenic
DOWNLOAD
Author : Tim Noakes
language : en
Publisher: Elsevier
Release Date : 2023-06-22
Ketogenic written by Tim Noakes and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-22 with Technology & Engineering categories.
Ketogenic: The Science of Therapeutic Carbohydrate Restriction in Human Health presents the most up-to-date and evidence-based science and research available in the field of TCR, with the purpose of training medical and allied healthcare professionals on the effective therapeutic use of low-carbohydrate and ketogenic nutrition in clinical practice. This book explores the appropriate, safe, and effective use of TCR to improve patient outcomes in a broad range of chronic metabolic conditions and aims to promote health. Focused on lifestyle management, health support and the treatment of diseases rooted in poor nutrition, this book explores the role of food and lifestyle modification as medicine and is a valuable resource for nutritionists, dietitians and medical professionals who provide diet-related counselling, as well as those researching or studying related areas. Presents new best-practice guidelines for using TCR to treat, improve or reverse nutrition-related metabolic conditions and diseases that were previously thought to have a chronic, irreversible progression Provides an overview of the most recent evidence outlining the biochemistry and physiology pertaining to human nutrition and health Offers evolutionary and historical context to human nutrition Contains clinical practice guidelines for the implementation of TCR from medical practitioners who prescribe TCR in their practices, allowing readers to understand real-life concerns in the field Features case studies that provide practical examples of how to assess, monitor and intervene with patients that practitioners encounter in their practices Explains the physiology and biochemistry of the normal and pathophysiological state for each condition and links these to the application of TCR
The Role Of Model Integration In Complex Systems Modelling
DOWNLOAD
Author : Manish I. Patel
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-08
The Role Of Model Integration In Complex Systems Modelling written by Manish I. Patel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-08 with Technology & Engineering categories.
Model integration – the process by which different modelling efforts can be brought together to simulate the target system – is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale. A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules. The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value.
Cancer As A Metabolic Disease
DOWNLOAD
Author : Thomas Seyfried
language : en
Publisher: John Wiley & Sons
Release Date : 2012-05-18
Cancer As A Metabolic Disease written by Thomas Seyfried and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-18 with Science categories.
The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.
Multiscale Modeling Of Cancer
DOWNLOAD
Author : Vittorio Cristini
language : en
Publisher: Cambridge University Press
Release Date : 2010-09-09
Multiscale Modeling Of Cancer written by Vittorio Cristini and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-09 with Technology & Engineering categories.
Mathematical modeling, analysis and simulation are set to play crucial roles in explaining tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial scales. This book, the first to integrate state-of-the-art numerical techniques with experimental data, provides an in-depth assessment of tumor cell modeling at multiple scales. The first part of the text presents a detailed biological background with an examination of single-phase and multi-phase continuum tumor modeling, discrete cell modeling, and hybrid continuum-discrete modeling. In the final two chapters, the authors guide the reader through problem-based illustrations and case studies of brain and breast cancer, to demonstrate the future potential of modeling in cancer research. This book has wide interdisciplinary appeal and is a valuable resource for mathematical biologists, biomedical engineers and clinical cancer research communities wishing to understand this emerging field.
Pathway Based Modeling And Diagnosis Of Cancer Development And Progression
DOWNLOAD
Author : Han-Yu Brook Chuang
language : en
Publisher:
Release Date : 2010
Pathway Based Modeling And Diagnosis Of Cancer Development And Progression written by Han-Yu Brook Chuang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
The advent of whole-genome expression profiling technology has made it possible to identify transcriptional dysregulation that contribute to or result from disease mechanisms and can also serve as biomarkers for disease. However, expression-alone classification can be challenging in complex diseases due to factors such as genetic heterogeneity across patients or noise in mRNA levels. Moreover, it remains unclear how these marker genes interrelate within a larger functional network. We propose a novel approach to integrate gene expression with protein interactions to dissect cancer development and outcome. The new prognostic markers are not individual genes or proteins, but as sets of coherently expressed genes whose products interact within a larger human protein interaction network. In breast cancer, we show that this integrated strategy predict the risk of metastasis potential more accurately than previous approaches based only on gene expression. More than being more reproducible and robust, our network markers also give molecular models for how the cancer susceptibility genes might be associated with cancer metastasis. We next apply this network-based analysis to develop a new system for accurately stratifying patients of chronic lymphocytic leukemia (CLL) at different risk levels of disease progression. The network markers represent an array of disease pathways whose expression converge over time among patients regardless their initial risk levels, implicating novel understanding for cancer evolution and for the development of treatment strategies. Besides incorporating protein interaction network into gene expression analyses, we also identify condition-responsive genes within canonical pathways to infer dysfunctional pathway activation. Contrast to methods based on static pathway knowledge, our dynamic pathway markers lead to better clinical performance for various cancers, including leukemia, prostate cancer, breast cancer and lung cancer. Another way to address the difficulties seen in gene expression studies is to obtain direct measurement of protein levels and states by quantitative mass spectrometry. We develop a method to select protein markers based on the change in expression relative to the standard deviation of repeated measurements across experimental replicates. In CLL disease progression, our protein markers are shown to be involved in the same pathways and more prognostic of newly diagnosed patients. We further discuss strategies for targeted proteomic profiling with the guidance of protein interaction networks.
The British National Bibliography
DOWNLOAD
Author : Arthur James Wells
language : en
Publisher:
Release Date : 2005
The British National Bibliography written by Arthur James Wells and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Bibliography, National categories.