Growth Factors And Their Receptors In Cell Differentiation Cancer And Cancer Therapy
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Growth Factors And Their Receptors In Cell Differentiation Cancer And Cancer Therapy
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Author : G V Sherbet
language : en
Publisher: Elsevier
Release Date : 2011-07-14
Growth Factors And Their Receptors In Cell Differentiation Cancer And Cancer Therapy written by G V Sherbet and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-14 with Medical categories.
Annotation G.V. Sherbet provides insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. The book focuses on the relationships and convergence of growth factors and their receptors in development and pathogenesis.
Growth Factors And Their Receptors In Cell Differentiation Cancer And Cancer Therapy
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Author : G. V. Sherbet
language : en
Publisher: Elsevier
Release Date : 2011-07
Growth Factors And Their Receptors In Cell Differentiation Cancer And Cancer Therapy written by G. V. Sherbet and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07 with Science categories.
Growth Factors And Their Receptors In Cancer Metastasis
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Author : Wen G. Jiang
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-11
Growth Factors And Their Receptors In Cancer Metastasis written by Wen G. Jiang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-11 with Medical categories.
about the involvement of signaling Transforming growth factor in tumor development and metastasis. plays a central role in the signaling network that controls morphogenesis, 2. THE BASICS OF growth and cell differentiation in SIGNALING multicellular organisms. The different members of this pleiotropic family of 2. 1. receptor signaling growth and differentiation factors seem to The family of growth factors regulate many processes in human disease consists of more than thirty members in and, in particular, tumor development. humans alone (15, 16). They cluster in Our understanding of how two major groups, the group composed of initiated signals are mediated has both the bone morphogenetic proteins increased dramatically in the last fifteen (BMP) and growth and differentiation years. Firstly, the prototype of factors (GDFs), and the group formed by this still constantly growing family, was the Activins, and Nodals. The two identified and cloned (1). Secondly, the groups differ in their use of receptors for family receptors were transmembrane receptors and the identified by expression cloning from subsequent activation of the mammalian tissue culture (2-7). Thirdly, transcriptional mediators (for recent genetic screens in Drosophila reviews see (13, 14, 17)).
Signal Transduction In Cancer
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Author : David A. Frank
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-12-31
Signal Transduction In Cancer written by David A. Frank and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-12-31 with Medical categories.
One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Transforming Growth Factor Beta In Cancer Therapy Volume Ii
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Author : Sonia B. Jakowlew
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-01-01
Transforming Growth Factor Beta In Cancer Therapy Volume Ii written by Sonia B. Jakowlew and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-01 with Medical categories.
Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology.
Egf Receptor In Tumor Growth And Progression
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Author : R.B. Lichtner
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Egf Receptor In Tumor Growth And Progression written by R.B. Lichtner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
The last 15 years have brought an understanding of growth and differentiation at the molecular level, expanding our knowledge of the origin and progression of cancer. Early breakthroughs defining growth control pathways came via studies of oncogenes, mutated signaling molecules that have lost the capacity to tum off their proliferative signal. Oncogenes with diverse growth-promoting activities have been discovered, covering the gamut from cell surface to nuclear signaling. Sequencing of these oncogenes revealed that they were mutated forms of captured cellular genes and displayed tyrosine kinase activity. The epidermal growth factor (EGF) receptor was the first of 40-50 transmembrane tyrosine kinase receptors to be cloned and sequenced. Beyond cell proliferation, activation of EGF receptor by its specific ligands controls important physiological processes, such as cell differentiation, apoptosis, cell migration, and cell shape. Activation of autocrine growth loops, consisting in solid human tumors of upregulated expression of EGFR together with increased production of ligands suggested its crucial role in autonomous tumor growth.
The Genetics Of Cancer
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Author : Gajanan V. Sherbet
language : en
Publisher: Academic Press
Release Date : 1997-06-22
The Genetics Of Cancer written by Gajanan V. Sherbet and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-06-22 with Medical categories.
Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology. Clonal evolution of the metastasis phenotype Cell Cycle regulation Apoptosis in tumour growth and metastasis Angiogenesis in cancer Cell surface glycoproteins and their receptors Proteinases and their inhibitors in cancer invasion Oncogenes and cancer metastasis Developmental genes Tumour suppressor genes Metastasis suppressor genes Dominant metastasis-associated genes
Oxford Textbook Of Oncology
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Author : David J. Kerr
language : en
Publisher: Oxford University Press
Release Date : 2016-01-28
Oxford Textbook Of Oncology written by David J. Kerr and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-28 with Medical categories.
Now in paperback, the Oxford Textbook of Oncology reflects current best practice in the multidisciplinary management of cancer, written and edited by internationally recognised leaders in the field. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.
Peptide Growth Factors And Their Receptors I
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Author : Michael B. Sporn
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Peptide Growth Factors And Their Receptors I written by Michael B. Sporn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors. Although there have been many symposia on this topic, and numerous publications of reviews dealing with selected subsets of growth factors, the entire field has never been covered in a single treatise. It is essential to do this at the present time, as the number of journal articles on peptide growth factors now makes it almost impossible for anyone person to stay informed on this subject by reading the primary literature. At the same time it is becoming increasingly apparent that these of universal importance in biology and medicine and that the substances are original classification of these molecules, based on the laboratory setting of their discovery, as "growth factors," "lymphokines," "cytokines," or "colony stimulating factors," was quite artifactual; they are in fact the basis of a com mon language for intercellular communication. As a set they affect essentially every cell in the body, and in this regard they provide the basis to develop a unified science of cell biology, germane to all of biomedical research. This treatise is divided into four main sections. After three introductory chapters, its principal focus is the detailed description of each of the major peptide growth factors in 26 individual chapters.
Therapeutic Strategies In Cancer Biology And Pathology
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Author : Gajanan V. Sherbet
language : en
Publisher: Elsevier
Release Date : 2013-07-26
Therapeutic Strategies In Cancer Biology And Pathology written by Gajanan V. Sherbet and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-26 with Medical categories.
Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. The emphasis in this book is on how appropriate these genes are as molecular targets and how practicable are the constituents of their signal transduction systems as potential candidates and how accessible they are to targeted therapy. Written in a straightforward and clear style with background information supporting the new research, this book will be useful for students and researchers in cancer therapies. Identifies molecular targets and their accessibility for therapeutic intervention Provides information on biological features of tumor development and dissemination Background information provided for each topic