Integration Of Pharmaceutical Discovery And Development
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Integration Of Pharmaceutical Discovery And Development
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Author : Ronald T. Borchardt
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-01-19
Integration Of Pharmaceutical Discovery And Development written by Ronald T. Borchardt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-19 with Science categories.
In the late 1980s, it became painfully evident to the pharmaceutical industry that the old paradigm of drug discovery, which involved highly segmented drug - sign and development activities, would not produce an acceptable success rate in the future. Therefore, in the early 1990s a paradigm shift occurred in which drug design and development activities became more highly integrated. This new str- egy required medicinal chemists to design drug candidates with structural f- tures that optimized pharmacological (e. g. , high affinity and specificity for the target receptor), pharmaceutical (e. g. , solubility and chemical stability), bioph- maceutical (e. g. , cell membrane permeability), and metabolic/pharmacokinetic (e. g. , metabolic stability, clearance, and protein binding) properties. Successful implementation of this strategy requires a multidisciplinary team effort, incl- ing scientists from drug design (e. g. , medicinal chemists, cell biologists, en- mologists, pharmacologists) and drug development (e. g. , analytical chemists, pharmaceutical scientists, physiologists, and molecular biologists representing the disciplines of pharmaceutics, biopharmaceutics, and pharmacokinetics/drug metabolism). With this new, highly integrated approach to drug design now widely utilized by the pharmaceutical industry, the editors of this book have provided the sci- tific community with case histories to illustrate the nature of the interdisciplinary interactions necessary to successfully implement this new approach to drug d- covery. In the first chapter, Ralph Hirschmann provides a historical perspective of why this paradigm shift in drug discovery has occurred.
Translating Molecules Into Medicines
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Author : Shobha N. Bhattachar
language : en
Publisher: Springer
Release Date : 2017-04-21
Translating Molecules Into Medicines written by Shobha N. Bhattachar and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-21 with Medical categories.
Tackling translational medicine with a focus on the drug discovery development-interface, this book integrates approaches and tactics from multiple disciplines, rather than just the pharmaceutical aspect of the field. The authors of each chapter address the paradox between the molecular understanding of diseases, drug discovery, and drug development. Laying out the detailed trends from various fields, different chapters are dedicated to target engagement, toxicological safety assessments, and the compelling relationship of optimizing early clinical studies with design strategies. The book also highlights the importance of balancing the three pillars: sufficient efficacy, acceptable safety and appropriate pharmacokinetics, all of which are crucial to successful efforts in discovery and development. With discussions regarding the combined approaches of molecular research, personalized medicine, pre-clinical and clinical development, as well as targeted therapies—this compendium is a flexible fit, perfect for professionals in the pharmaceutical industry and related academic fields.
Complete Accounts Of Integrated Drug Discovery And Development
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Author : Jaan A. Pesti
language : en
Publisher:
Release Date : 2020-10-09
Complete Accounts Of Integrated Drug Discovery And Development written by Jaan A. Pesti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-09 with Science categories.
These engaging accounts walk readers through the drug discovery and development processes, from identification of a target compound to the development of large-scale processes. The authors hail from leading pharmaceutical companies, grounding the text in real-world applications. These accounts also touch on reaction safety and development costs, providing insight into often closed-door procedures. These relevant examples from industry are informative to chemists in both industry and academia, especially those interested in discovering and developing drug candidates.
Predictive Admet
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Author : Jianling Wang
language : en
Publisher: John Wiley & Sons
Release Date : 2014-02-28
Predictive Admet written by Jianling Wang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-28 with Medical categories.
This book helps readers integrate in silico, invitro, and in vivo ADMET (absorption,distribution, metabolism, elimination and toxicity) and PK(pharmacokinetics) data with routine testing applications so thatpharmaceutical scientists can diagnose ADMET problems and presentappropriate recommendations to move drug discovery programsforward. The book introduces the current clinical practice for drugdiscovery and development along with the impact on early riskassessment; consolidates the tools and models to intelligentlyintegrate existing in silico, invitro and in vivo ADMET data; anddemonstrates successful cases and lessons learned from real drugdiscovery and development. In short, it is a book aimed to providea practical road map for drug discovery and development scientiststo generate efficacious and safe drugs for unmet medical needs.
Systems Biology In Drug Discovery And Development
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Author : Daniel L. Young
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-23
Systems Biology In Drug Discovery And Development written by Daniel L. Young and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-23 with Medical categories.
The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.
Complete Accounts Of Integrated Drug Discovery And Development
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Author :
language : en
Publisher:
Release Date : 2022
Complete Accounts Of Integrated Drug Discovery And Development written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Genomics In Drug Discovery And Development
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Author : Dimitri Semizarov
language : en
Publisher: John Wiley & Sons
Release Date : 2008-11-03
Genomics In Drug Discovery And Development written by Dimitri Semizarov and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-03 with Medical categories.
Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis, Genomics in Drug Discovery and Development introduces readers to the biomarker, pharmacogenomic, and toxicogenomics toolbox. The authors provide a valuable resource for pharmaceutical discovery scientists, preclinical drug safety department personnel, regulatory personnel, discovery toxicologists, and safety scientists, drug development professionals, and pharmaceutical scientists.
Complete Accounts Of Integrated Drug Discovery And Development
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Author : Jaan A. Pesti
language : en
Publisher:
Release Date : 2021-09-03
Complete Accounts Of Integrated Drug Discovery And Development written by Jaan A. Pesti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-03 with categories.
Case studies from the pharmaceutical industry This book describes the continuum from discovery to development. Readers will learn how recent drugs, including grazoprevir, melflufen, relebactam, and tesirine, were developed. The book highlights emerging concepts, new developments, and challenges during the discovery process. Well-known authors from the pharmaceutical industry provide an inside look to traditionally closed-door procedures. Profssional chemists and students alike will find these accounts extremely valuable.
Complete Accounts Of Integrated Drug Discovery And Development
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Author :
language : en
Publisher:
Release Date : 2019
Complete Accounts Of Integrated Drug Discovery And Development written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Drug Discovery And Development Volume 1
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Author : Mukund S. Chorghade
language : en
Publisher: John Wiley & Sons
Release Date : 2006-07-18
Drug Discovery And Development Volume 1 written by Mukund S. Chorghade and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-18 with Science categories.
From first principles to real-world applications -- here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines--from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and development--from initial conceptualization to commercialization to clinicians and medical practitioners. Volume 1: Drug Discovery describes all the steps in the discovery process, including conceptualizing a drug, creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and modifying a drug as necessary. Volume 2: Drug Development delves into the nitty-gritty details of optimizing the synthetic route, drug manufacturing, outsourcing, and marketing--including drug coloring and delivery methods. Featuring contributions from a world-class team of experts, Drug Discovery and Development: * Features fascinating case studies, including the discovery and development of erythromycin analogs, Tagamet, and Ultiva (remifentanil) * Discusses the discovery of medications for bacterial infections, Parkinson's disease, psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer * Includes chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics Drug Discovery and Development is an indispensable working resource for industrialchemists, biologists, biochemists, and executives who work in the pharmaceutical industry.