Integrative Omics In Parkinson S Disease
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Integrative Omics In Parkinson S Disease
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Author : Joanne Trinh
language : en
Publisher: Academic Press
Release Date : 2024-11-21
Integrative Omics In Parkinson S Disease written by Joanne Trinh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-21 with Medical categories.
Integrative Omics in Parkinson’s Disease provides a comprehensive understanding of the current literature on genomics and exposomic technologies relating to Parkinson's Disease etiology. This emerging field uses large omics datasets to investigate the etiology of Parkinson’s disease and other forms of parkinsonisms. The book begins by introducing the readers to evolution of omics technologies, starting with the first identification of monogenic forms of Parkinson’s disease. Next, a series of chapters covering genomics, transcriptomics, and epigenomics, including artificial intelligence and gene-environment interaction are included. Lastly, potential application of advances in the field to therapy and what is in store for the future generation for omics in Parkinson's Disease are reviewed.
Integrative Approach To Parkinson S Disease
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Author : Hi-Joon Park
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-30
Integrative Approach To Parkinson S Disease written by Hi-Joon Park and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-30 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Integrative Omics
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Author : Manish Kumar Gupta
language : en
Publisher: Elsevier
Release Date : 2024-05-10
Integrative Omics written by Manish Kumar Gupta and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-10 with Science categories.
Integrative Omics: Concepts, Methodology and Applications provides a holistic and integrated view of defining and applying network approaches, integrative tools, and methods to solve problems for the rationalization of genotype to phenotype relationships. The reference includes a range of chapters in a systemic ‘step by step’ manner, which begins with the basic concepts from Omic to Multi Integrative Omics approaches, followed by their full range of approaches, applications, emerging trends, and future trends. All key areas of Omics are covered including biological databases, sequence alignment, pharmacogenomics, nutrigenomics and microbial omics, integrated omics for Food Science and Identification of genes associated with disease, clinical data integration and data warehousing, translational omics as well as omics technology policy and society research. Integrative Omics: Concepts, Methodology and Applications highlights the recent concepts, methodologies, advancements in technologies and is also well-suited for researchers from both academic and industry background, undergraduate and graduate students who are mainly working in the area of computational systems biology, integrative omics and translational science. The book bridges the gap between biological sciences, physical sciences, computer science, statistics, data science, information technology and mathematics by presenting content specifically dedicated to mathematical models of biological systems. Provides a holistic, integrated view of a defining and applying network approach, integrative tools, and methods to solve problems for rationalization of genotype to phenotype relationships Offers an interdisciplinary approach to Databases, data analytics techniques, biological tools, network construction, analysis, modeling, prediction and simulation of biological systems leading to ‘translational research’, i.e., drug discovery, drug target prediction, and precision medicine Covers worldwide methods, concepts, databases, and tools used in the construction of integrated pathways
Integrative Multi Omics For Diagnosis Treatments And Drug Discovery Of Aging Related Neuronal Diseases
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Author : Min Tang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-23
Integrative Multi Omics For Diagnosis Treatments And Drug Discovery Of Aging Related Neuronal Diseases written by Min Tang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-23 with Science categories.
As the cost of high-throughput sequencing goes down, huge volumes of biological and medical data have been produced from various sequencing platforms at multiple molecular levels including genome, transcriptome, proteome, epigenome, metabolome, and so on. For a long time, data analysis on single molecular levels has paved the way to answer many important research questions. However, many Aging-Related Neuronal Diseases (ARNDs) and Central Nervous System (CNS) aging involve interactions of molecules from multiple molecular levels, in which conclusions based on single molecular levels are usually incomplete and sometimes misleading. In these scenarios, multi-omics data analysis has unprecedentedly helped capture much more useful information for the diagnosis, treatment, prognosis, and drug discovery of ARNDs. The first step towards a multi-omics analysis is to establish reliable and robust multi-omics datasets. In the past years, a few important ARNDs-associated multi-omics databases like Allen Brain have been constructed, which raised immediate needs like data curation, normalization, interpretation, and visualization for integrative multi-omics explorations. Though there have been several well-established multi-omics databases for ARNDs like Alzheimer’s disease, similar databases for other ARNDs are still in urgent need. After the databases establish, many computational tools and experiential strategies should be developed specifically for them. First, the multi-omics data are usually extremely noisy, complex, heterogeneous and in high dimension, which presents the need for appropriate denoising and dimension reduction methods. Second, since the multi-omics and non-omics data like pathological and clinical data are usually in different data spaces, a useful algorithm to mapping them into the same data space and integrate them is nontrivial. In the multi-omics era, there are numerous data-centric tools for the integration of multi-omics datasets, which could be generally divided into three categories: unsupervised, supervised, and semi-supervised methods. Commonly used algorithms include but not limited to Bayesian-based methods, Network-based methods, multi-step analysis methods, and multiple kernel learning methods. Third, methods are needed in studying and verifying the association between two or more levels of multi-omics data and non-omics data. For example, expression quantitative trait loci (eQTL) analysis is widely used to infer the association between a single nucleotide polymorphism (SNP) and the expression of a gene. Recently, the association between omics data and more complex data like pathological and clinical imaging data has been a hot research topic. The outcomes may reveal the underlying molecular mechanism and promote de novo drug design as well as drug repurposing for ARNDs. Here, we welcome investigators to share their Original Research, Review, Mini Review, Hypothesis and Theory, Perspective, Conceptual Analysis, Data Report, Brief Research Report, Code related to multi-omics studies of ARNDs, which can be applied for better diagnosis, treatment, prognosis and drug discovery of human diseases in the future era of precision medicine. Potential contents include but are not limited to the following: ▪ Methods for integrating, interpreting, or visualizing two or more omics data. ▪ Methods for identifying interactions between different data modalities. ▪ Methods for disease subtyping, biomarker prediction. ▪ Machine learning or deep learning methods on dimensional reduction and feature selection for big noisy data. ▪ Methods for studying the association among different omics data or between omics and non-omics data like clinical, pathological, and imaging data. ▪ Review of multi-omics resource about ARNDs and/or CNS aging. ▪ Experimental validation of biomarkers identified from multi-omics data analysis. ▪ Disease diagnosis and prognosis prediction from imaging and non-imaging data analysis, or both. ▪ Clinical applications or validations of findings from multi-omics data analysis.
Recent Developments In Parkinson S Disease
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Author : Stanley Fahn
language : en
Publisher:
Release Date : 1986
Recent Developments In Parkinson S Disease written by Stanley Fahn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Medical categories.
Multi Omics For The Understanding Of Brain Diseases
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Author :
language : en
Publisher:
Release Date : 2021-12-13
Multi Omics For The Understanding Of Brain Diseases written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-13 with Science categories.
Microbial Omics In Environment And Health
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Author : Minu Kesheri
language : en
Publisher: Springer Nature
Release Date :
Microbial Omics In Environment And Health written by Minu Kesheri and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Extracellular Matrix Omics
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Author : Sylvie Ricard-Blum
language : en
Publisher: Springer Nature
Release Date : 2020-12-15
Extracellular Matrix Omics written by Sylvie Ricard-Blum and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-15 with Science categories.
This book covers different omics aspects related to the extracellular matrix (ECM), namely specific omics resources focused on the extracellular matrix (e.g., databases, repositories and atlases), quantitative proteomics applied to specific extracellular matrices (e.g. basement membranes), biological processes such as ECM degradation (degradomics), cell-matrix interactions (adhesomes), signaling pathways, biomarker discovery and diseases, and interactomics (extracellular matrix interaction networks including not only protein-protein but also protein-glycosaminoglycan interactions). The volume also includes recent advances in glycomics and glycobioinformatics applied to proteoglycans and glycosaminoglycans, which are key biological players. The use of omics data to build dynamic models of ECM-regulated biological pathways is addressed, together with the requirement to standardize omic data, which is a prerequisite for the FAIR (Findability, Accessibility, Interoperability, and Reusability) guiding principles for scientific data management. This book will be of great interest to a broad readership from beginners to advanced researchers, who are interested in extracellular matrix omics and will inspire future research topics.
Omics
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Author : Debmalya Barh
language : en
Publisher: CRC Press
Release Date : 2011-11-21
Omics written by Debmalya Barh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-21 with Medical categories.
A reflection of the explosion of research and development in this field, OMICS: Biomedical Perspectives and Applications explores applications of omics in bioinformatics, cancer research and therapy, diabetes research, plant science, molecular biology, and neurosciences. A select editorial panel of experts discusses their cutting edge omics research and novel technologies, supplying a basic platform of methods and applications and a resource for enhanced cross-pollination in a multiomics approach to future endeavors in the fertile fields of omics research. After an introduction on the omics universe, the book presents modern omics and its applications in nanotechnology, genomics, proteomics, metagenomics, toxicogenomics, immunomics, nutrigenomics, diabetes, neurology, cardiology, and cancer to name just a few. The book begins with an overview of omics and omic technologies such as cellomics, glycomics, and lipidomics. It also discusses bioinformatics, demonstrating how it can be a tool in omics, and examines the various approaches of omics technology in toxicology research and applications in biomedical sciences. While there are a long list of omics books available, most focus narrowly on one area. Presenting a wide view of the current status of integrative omics, this resource contains complete coverage of omics in research and therapy, ranging from neuroscience to cardiology. It collates recent developments in the field into a state-of-the-art framework for this discipline.
Biotechnology And Drug Development For Targeting Human Diseases
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Author : Israel Valencia Quiroz
language : en
Publisher: Bentham Science Publishers
Release Date : 2024-03-14
Biotechnology And Drug Development For Targeting Human Diseases written by Israel Valencia Quiroz and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-14 with Science categories.
Biotechnology and Drug Development for Targeting Human Diseases is an insightful compendium on drug development technologies for professionals and students in biotechnology and pharmacology. This book meticulously explores the intersection of biotechnology with drug development, emphasizing its crucial role in creating new therapies for human disease. Central to the book is the innovative use of biotechnology in understanding and treating diseases. It begins with an exploration of multi-omics profiles, shedding light on disease mechanisms and drug development. Subsequent chapters explain in silico methods for drug design, the role of natural products in antimicrobial applications and wound healing, and the use of viruses as carriers in biotechnology. Key features of this reference include a blend of theoretical knowledge and practical insights, detailed analyses of molecular docking in drug discovery, the repurposing of drugs for various diseases, and the emerging field of omics technologies in drug interaction studies. Each chapter is comprehensive, offering current information backed by extensive references, making the book both a foundational and advanced resource. Readership Students and professionals in the fields of biotechnology and pharmacology.