Integrins In Health And Disease
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Integrins In Health And Disease
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Author : Donald Gullberg
language : en
Publisher: Springer Nature
Release Date : 2023-03-10
Integrins In Health And Disease written by Donald Gullberg and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-10 with Science categories.
Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis. This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of integrins in pathological tissue remodeling in joints and in developing and diseased cardiac tissue are discussed. Reviews of the current knowledge of the role of integrins in tissue and tumor fibrosis, angiogenesis and tumor progression are an important part of this work. Finally, the book discusses integrins in the context of the immune system, how to target integrin-ligand interactions with antibodies, and the role of integrins as receptors for bacterial and viral cell invasion. Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and cell adhesion molecules will find “Integrins in Health and Disease - Key Effectors of Cell-Matrix and Cell-Cell Interactions” authoritative, easily accessible, and vastly informative. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
Integrin Adhesion Receptors In Health And Disease
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Author : Andreja Ambriovic-Ristov
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-17
Integrin Adhesion Receptors In Health And Disease written by Andreja Ambriovic-Ristov and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-17 with Science categories.
Adhesion Molecules In Health And Disease
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Author : Paul
language : en
Publisher: CRC Press
Release Date : 1997-05-16
Adhesion Molecules In Health And Disease written by Paul and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-05-16 with Science categories.
Provides an overview of the structure, transcription regulation and binding characteristics of cellular adhesion molecules and their ligands in the maintenance of function, immunological reactions and inflammatory processes with organ systems. The text examines the role of adhesion molecules in biological processes such as morphogenesis, blood coagulation, tumour metastasis, bone tissue remodelling and transplant rejection.
Cell Adhesion Molecules And Matrix Proteins
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Author : Shaker A. Mousa
language : en
Publisher:
Release Date : 1998
Cell Adhesion Molecules And Matrix Proteins written by Shaker A. Mousa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Integrins Anti Integrins
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Author : Vanadiya Ermekova
language : en
Publisher:
Release Date : 2006-07
Integrins Anti Integrins written by Vanadiya Ermekova and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07 with categories.
Integrins play a critical role in numerous vital processes on the systemic, tissue, cell, and molecular levels. These include homeostasis; immunity; hematopoiesis; fertility and embryogenesis; cell proliferation, differentiation, cell cycle division and apoptosis; and gene expression. Impairment of integrins' functions causes the dramatic remodeling of these processes. Prolonged therapy with anti-α4β antibodies may result in severe pathological consequences, including generalized immunosuppression leading to an extreme risk of very serious infections; uncontrolled proliferation and altered differentiation of hematopoietic cells possibly leading to hematological abnormalities and increased risk of malignancies; and alterations in spermatogenesis, fertility, and embryonic development. Natalizumab (Tysabri) is an impressively effective drug. In the professional opinion of well-known neurologists it is considered to be a promising agent for the treatment of multiple sclerosis. However, whereas the evaluation of the drug's benefits can be done by neurologists alone, it is mandatory that the risk in using this agent should be assessed by a team of experts in a number of fields: immunology, infectious diseases, hematology, oncology, and embryology. It is essential to recognize that innovative integrin-antagonist therapy, e.g. therapy with anti-α4β integrin monoclonal antibodies, must be handled with extreme caution.
Cell Adhesion Molecules In Health And Disease
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Author : W. Reutter
language : en
Publisher: Springer
Release Date : 2003-10-31
Cell Adhesion Molecules In Health And Disease written by W. Reutter and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-31 with Medical categories.
This book is the proceedings of a Falk Workshop held in Berlin, Germany, on January 23-24, 2003, which brought together experts in different fields of research to stimulate the transfer of findings from basic research to clinical application. Section I focuses on cell adhesion molecules of the liver and their role in hepatocarcinogenesis and inflammatory liver disease. Section II deals with infection and fibrosis and with transforming growth factor beta (TGF-beta). Morphogenesis, cell migration and inflammation are the subject of Section III with a focus on the role of integrins in blood cell-endothelial interactions. In Section IV the importance of cell adhesion molecules for cancer and their role as potential target for cancer therapy will be discussed.
Asthma And Copd
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Author : Peter J. Barnes
language : en
Publisher: Elsevier
Release Date : 2009-03-19
Asthma And Copd written by Peter J. Barnes and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-19 with Medical categories.
The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations
Immunoreceptor Tyrosine Based Inhibition Motifs
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Author : Marc Daëron
language : en
Publisher: Springer Science & Business Media
Release Date : 1999
Immunoreceptor Tyrosine Based Inhibition Motifs written by Marc Daëron and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Novel molecular motifs named immunoreceptor tyrosine-based inhibition motifs (ITIMs) have recently been recognized in the intracytoplasmic domains of an increasing number of receptors which control cell activation and proliferation. Research on ITIM-bearing molecules has developed exponentially during the last three years, generating new concepts with important consequences in basic research, and with potential clinical applications. The present volume contains 15 reviews written by authors who made significant contributions to the identification of ITIM-bearing molecules and the study of their biological properties.
Anoikis
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Author : Steven M. Frisch
language : en
Publisher: Springer Nature
Release Date : 2021-07-27
Anoikis written by Steven M. Frisch and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-27 with Medical categories.
Anoikis is defined broadly as apoptosis that is inhibited by appropriate cell-matrix interactions. Normal and tumor cells vary widely in their sensitivity to anoikis, but, in general, metastatic tumor cells are inevitably anoikis-resistant. In particular, tumor cells that possess a cancer stem cell or mesenchymal phenotype, arising from the oncogenic Epithelial-Mesenchymal Transition (EMT), are transcriptionally re-programmed to resist anoikis. While the anoikis response occurs through the mitochondrial pathway typically found in other apoptotic responses (e.g., DNA damage, death receptors, oxidative stress), the regulation of anoikis by cell-matrix signalling is unique and only partially characterized. The uniqueness of anoikis is: a. regulation by integrins, non-integrin matrix receptors, and the signaling complexes associated with them; b. regulation by metabolic changes occurring in response to attachment/detachment; c. regulation by oncogenes and tumor suppressor genes d. regulation by tumor microenvironment; e. regulation by EMT.