Interferon S New Regulators Of Inflammatory Processes
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Interferon S New Regulators Of Inflammatory Processes
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Author : Ivan Zanoni
language : en
Publisher: Frontiers Media SA
Release Date : 2020-01-14
Interferon S New Regulators Of Inflammatory Processes written by Ivan Zanoni and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-14 with categories.
Regulation Of Interferon Regulatory Factors In Lps Stimulated Macrophages
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Author :
language : en
Publisher:
Release Date : 1995
Regulation Of Interferon Regulatory Factors In Lps Stimulated Macrophages written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
Macrophages secrete interferons (IFNs), as well as other inflammatory cytokines, following stimulation with lipopolysaccharide (LPS), the outer membrane component of Gram negative bacteria that has been implicated as the initiator of the sepsis-associated Systemic Inflammatory Response Syndrome (SIRS). The interferon regulatory factors (IRFs) comprise a family of DNA binding proteins that positively and negtively regulate transcription of IFN and certain IFN-inducible genes. Basal and LPS-inducible levels of mRNA expressed by three IRF family member genes, i.e., IRF-1, IRF-2, and ICSBP, as well as a panel of other well characterized, SIRS-associated, inflammatory genes, were analyzed in macrophages derived from fully LPS-responsive mouse strains (Lps(n)), genetically LPS-hyporesponsive (Lps(d)) mice, IRF-1 and IRF-2 'knockout' mice, as well as from Lpsn macrophages rendered 'endotoxin tolerant' in vitro. Our results suggest that the IRF nuclear binding proteins, as well as serine/threonine phosphatases, play important roles in LPS-induced gene expression and may provide novel targets for therapeutic intervention, not only in Gram negative sepsis, but also in other syndromes characterized by inflammatory mediator excess.
Fields Virology Emerging Viruses
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Author : Peter M. Howley
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2020-02-11
Fields Virology Emerging Viruses written by Peter M. Howley and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-11 with Medical categories.
Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: Emerging Viruses, 7th Edition covers recent changes in emerging viruses, providing new or extensively revised chapters that reflect these advances in this dynamic field.
Encyclopedia Of Signaling Molecules
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Author :
language : en
Publisher:
Release Date : 19??
Encyclopedia Of Signaling Molecules written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 19?? with categories.
Innovative Medicine
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Author : Kazuwa Nakao
language : en
Publisher: Springer
Release Date : 2015-10-13
Innovative Medicine written by Kazuwa Nakao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-13 with Science categories.
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Biotechnology And Biopharmaceuticals
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Author :
language : en
Publisher: John Wiley & Sons
Release Date : 2013-12-16
Biotechnology And Biopharmaceuticals written by and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-16 with Science categories.
Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs, Second Edition addresses the pivotal issues relating to translational science, including preclinical and clinical drug development, regulatory science, pharmaco-economics and cost-effectiveness considerations. The new edition also provides an update on new proteins and genetic medicines, the translational and integrated sciences that continue to fuel the innovations in medicine, as well as the new areas of therapeutic development including cancer vaccines, stem cell therapeutics, and cell-based therapies.
The Innate Immune Response To Noninfectious Stressors
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Author : Massimo Amadori
language : en
Publisher: Academic Press
Release Date : 2016-02-23
The Innate Immune Response To Noninfectious Stressors written by Massimo Amadori and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-23 with Medical categories.
The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation. Provides insights into the fundamental homeostatic processes vis-à-vis stressors to help in investigation Illustrates the depicted tenets and how to offset them against established models of response to physical and psychotic stressors in both animals and humans Covers the crucial issue of the immune response to endocrine disruptors Includes immunological parameters as reporter system of environmental adaptation Provides many illustrative examples to foster reader understanding
Nijkamp And Parnham S Principles Of Immunopharmacology
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Author : Michael J. Parnham
language : en
Publisher: Springer Nature
Release Date : 2019-12-10
Nijkamp And Parnham S Principles Of Immunopharmacology written by Michael J. Parnham and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-10 with Medical categories.
Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks. The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third section contains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests. Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions. The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.
New Advances And Contributions To Fish Biology
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Author : Hakan Turker
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-11-21
New Advances And Contributions To Fish Biology written by Hakan Turker and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-21 with Science categories.
This book provides an understanding on a large variety of related topics in fish biology. The further development on molecular and cellular biology and ecology leads to assimilate the newer scientific knowledge in this area. Leading research works from around the world are brought together in this book to produce a valuable source of reference for teachers, researcher, and advanced students of biological science. The fist three chapters of this book give a general description of the complex biology of the immune response. Detailed descriptions were also included on understanding of cytokine regulation in teleost immune system. The second three chapters provide information on the environmental stressors on the responses of freshwater fish across molecular to population level. Then, the following two chapters review two special topics; the roles of the atrium and the ventricle across teleost species and the tracer methodologies on the measurements of carbohydrate metabolism. The last chapter discusses the variables that are involved in the feeding behavior of a predatory freshwater fish species.
Innate Immunity In Health And Disease
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Author : Shailendra K. Saxena
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-08-25
Innate Immunity In Health And Disease written by Shailendra K. Saxena and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-25 with Medical categories.
The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.