Interrogation Of Kinase Mediated Signaling Pathways To Decode Human Cell Division
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Interrogation Of Kinase Mediated Signaling Pathways To Decode Human Cell Division
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Author : Amber Lynn Lasek
language : en
Publisher:
Release Date : 2016
Interrogation Of Kinase Mediated Signaling Pathways To Decode Human Cell Division written by Amber Lynn Lasek and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Protein interactions within a living cell are complex and are necessary for transmitting signals quickly and accurately. Kinases provide an important source of regulation and communication and play important roles for triggering and maintaining signaling cascades. These processes are themselves restrained so that they occur at the correct time and place. Due to the complexity of these processes and the need for improved methods, there remain many unresolved questions regarding the interconnectedness of signaling pathways and the extent that posttranslational modifications on kinases play for regulating kinase activity and function. Many kinases are known to be activated by phosphorylation within its catalytic loop; however, these proteins have multiple sites of modification including additional sites of phosphorylation and ubiquitination. Whether and how much these sites influence the activity and function of the kinase is unresolved. Using analog-specific kinases, I have discovered that Plk1 is not only regulated by the activating phosphorylation within the catalytic loop, T210, but also requires a neighboring site, T214. Additionally, other phosphorylation sites within the catalytic domain, but not in the C-terminal localization domain, redundantly control mitotic functions of Plk1 and cell cycle progression. These results demonstrate the intricacy of signaling to control and regulate Plk1. Further analysis of the complexity of signaling within a cell is demonstrated by comparing the pathways of two proteins. For a cellular process, involved proteins can act in parallel or overlapping pathways. If they overlap, can moderately perturbing a pathway from multiple directions simultaneously cause a greater response than each individual assault? This idea was used to design a screen between differing therapeutic agents. Many of the drugs include those that directly target proteins key to signaling pathways, kinases, while others were agents that would activate signaling pathways through error induction, such as mitotic checkpoint signaling activation with nocodazole treatment. Aurora A inhibition was found to potentiate the effect of a Plk1 inhibitor, a pan-Cdk inhibitor, and DNA damage response inducer, IUdR. Overall, this work expands the knowledge of and provides insight into the way that signaling networks function within the cell.
Myeloid Cells In Health And Disease
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Author : Siamon Gordon
language : en
Publisher: John Wiley & Sons
Release Date : 2020-07-10
Myeloid Cells In Health And Disease written by Siamon Gordon and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-10 with Science categories.
The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells. In Myeloid Cells in Health and Disease: A Synthesis, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including the recruitment of myeloid and other immune cells following microbial infection the role of myeloid cells in the inflammation process and the repair of damaged tissue the vast arsenal of myeloid cell secretory molecules, including metalloproteinases, tumor necrosis factor, histamine, and perforin receptors and downstream signaling pathways that are activated following ligand-receptor binding roles of myeloid cells during microbial and parasite infections contributions of myeloid cells in atherosclerosis myeloid-derived suppressor cells in tumor development and cancer Myeloid Cells in Health and Disease: A Synthesis will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book's rich history of myeloid cell research and suggestions for future research directions and potential therapies.
The Computational Brain 25th Anniversary Edition
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Author : Patricia S. Churchland
language : en
Publisher: MIT Press
Release Date : 2016-11-04
The Computational Brain 25th Anniversary Edition written by Patricia S. Churchland and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-04 with Science categories.
An anniversary edition of the classic work that influenced a generation of neuroscientists and cognitive neuroscientists. Before The Computational Brain was published in 1992, conceptual frameworks for brain function were based on the behavior of single neurons, applied globally. In The Computational Brain, Patricia Churchland and Terrence Sejnowski developed a different conceptual framework, based on large populations of neurons. They did this by showing that patterns of activities among the units in trained artificial neural network models had properties that resembled those recorded from populations of neurons recorded one at a time. It is one of the first books to bring together computational concepts and behavioral data within a neurobiological framework. Aimed at a broad audience of neuroscientists, computer scientists, cognitive scientists, and philosophers, The Computational Brain is written for both expert and novice. This anniversary edition offers a new preface by the authors that puts the book in the context of current research. This approach influenced a generation of researchers. Even today, when neuroscientists can routinely record from hundreds of neurons using optics rather than electricity, and the 2013 White House BRAIN initiative heralded a new era in innovative neurotechnologies, the main message of The Computational Brain is still relevant.
Make Life Visible
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Author : Yoshiaki Toyama
language : en
Publisher: Springer Nature
Release Date : 2019-10-02
Make Life Visible written by Yoshiaki Toyama and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-02 with Medical categories.
This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.
Neuropsychiatric Disorders
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Author : Gareth W. Roberts
language : en
Publisher: Mosby Elsevier Health Science
Release Date : 1993
Neuropsychiatric Disorders written by Gareth W. Roberts and has been published by Mosby Elsevier Health Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.
An account of the known anatomy, pathology, molecular biology and diagnosis of neuropsychiatric diseases, this text combines clinical, radiological and laboratory illustrations for comparative information. It deals with dementias, psychoses, congenital disorders, epilepsy and motor disorders.
Glycan Based Cellular Communication
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Author : Peng George Wang
language : en
Publisher:
Release Date : 2020
Glycan Based Cellular Communication written by Peng George Wang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Carbohydrates categories.
Epigenetic Regulation And Epigenomics
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Author : Robert A. Meyers
language : en
Publisher: John Wiley & Sons
Release Date : 2012-10-02
Epigenetic Regulation And Epigenomics written by Robert A. Meyers and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-02 with Science categories.
Epigenetics is a term in biology referring to heritable traits that do not involve changes in the underlying DNA sequence of the organism. Epigenetic traits exist on top of or in addition to the traditional molecular basis for inheritance. The "epigenome" is a parallel to the word "genome," and refers to the overall epigenetic state of a cell. Cancer and stem cell research have gradually focused attention on these genome modifications. The molecular basis of epigenetics involves modifications to DNA and the chromatin proteins that associate with it. Methylation, for example, can silence a nearby gene and seems to be involved in some cancers. Epigenetics is beginning to form and take shape as a new scientific discipline, which will have a major impact on Medicine and essentially all fields of biology. Increasingly, researchers are unearthing links between epigenetics and a number of diseases. Although in recent years cancer has been the main focus of epigenetics, recent data suggests that epigenetic plays a critical role in psychology and psychopathology. It is being realized that normal behaviors such as maternal care and pathologies such as Schizophrenia and Alzheimer's might have an epigenetic basis. It is also becoming clear that nutrition and life experiences have epigenetic consequences. Discover more online content in the Encyclopedia of Molecular Cell Biology and Molecular Medicine.
Industrial Pharmaceutical Biotechnology
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Author : Heinrich Klefenz
language : de
Publisher: Wiley-VCH
Release Date : 2002-04-22
Industrial Pharmaceutical Biotechnology written by Heinrich Klefenz and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-22 with Medical categories.
This volume focuses on pharmaceutical biotechnology as a key area of life sciences. The complete range of concepts, processes and technologies of biotechnology is applied in modern industrial pharmaceutical research, development and production. The results of genome sequencing and studies of biological-genetic function are combined with chemical, micro-electronic and microsystem technology to produce medical devices and diagnostic biochips. A multitude of biologically active molecules is expanded by additional novel structures created with newly arranged gene clusters and bio-catalytic chemical processes. New organisational structures in the co-operation of institutes, companies and networks enable faster knowledge and product development and immediate application of the results of research and process development. This book is the ideal source of information for scientists and engineers in research and development, for decision-makers in biotech, pharma and chemical corporations, as well as for research institutes, but also for founders of biotech companies and people working for venture capital corporations.
A Handbook For Dna Encoded Chemistry
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Author : Robert A. Goodnow, Jr.
language : en
Publisher: John Wiley & Sons
Release Date : 2014-04-28
A Handbook For Dna Encoded Chemistry written by Robert A. Goodnow, Jr. and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-28 with Science categories.
This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry Helps chemists generate and screen novel chemical libraries of large size and quality Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry Shows medicinal and pharmaceutical chemists how to efficiently broaden available “chemical space” for drug discovery Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods
Immunoinformatics
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Author : Christian Schönbach
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-21
Immunoinformatics written by Christian Schönbach and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-21 with Medical categories.
In contrast to existing books on immunoinformatics, this volume presents a cross-section of immunoinformatics research. The contributions highlight the interdisciplinary nature of the field and how collaborative efforts among bioinformaticians and bench scientists result in innovative strategies for understanding the immune system. Immunoinformatics is ideal for scientists and students in immunology, bioinformatics, microbiology, and many other disciplines.