Introduction To Drug Metabolism
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Introduction To Drug Metabolism
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Author : G. Gordon Gibson
language : en
Publisher: Nelson Thornes
Release Date : 2001
Introduction To Drug Metabolism written by G. Gordon Gibson and has been published by Nelson Thornes this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
Of drug-metabolising reactions. p. 25.
Introduction To Drug Metabolism
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Author : G. GORDON GIBSON AND PAUL SKETT
language : en
Publisher: Springer
Release Date : 2013-12-11
Introduction To Drug Metabolism written by G. GORDON GIBSON AND PAUL SKETT and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-11 with Medical categories.
This introduction to the mechanisms by which the body metabolizes and excretes administered drugs is directed at advanced undergraduate biochemists, pharmacologists, pre-clinical medical students and advanced undergraduate/postgraduate toxicologists.
Human Drug Metabolism
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Author : Michael D. Coleman
language : en
Publisher: John Wiley & Sons
Release Date : 2010-03-30
Human Drug Metabolism written by Michael D. Coleman and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-30 with Science categories.
Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.
Introduction To Drug Metabolism
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Author : G. Gordon Gibson
language : en
Publisher: Springer
Release Date : 2013-11-11
Introduction To Drug Metabolism written by G. Gordon Gibson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
Although the scientific literature on drug metabolism is extensive, it suffers from the disadvantage that the material is diffuse and consists largely of specialist monographs dealing with particular aspects of the subject. In addi tion, although there are a few excellent texts on drug metabolism in print, these tend to be earlier publications and hence do not take into account the many recent advances in this area. Our motivations for writing this book therefore arose from the clear need for a recent and cohesive introductory text on this subject, specifically designed to cater for the needs of undergraduate and postgraduate students. Much of the subject matter in this text is derived from various courses on drug metabolism given at the University of Surrey and the University of Glasgow to basic science students in pharmacology, biochemistry, nutrition and nursing studies, to pre-clinical medical students and to under graduate and post-graduate students in toxicology. Therefore, it is our inten tion that this text will serve as a primer in drug metabolism to a variety of students in the life sciences taking courses in this subject. The term 'drug metabolism' in its broadest sense may be considered as the absorption, distribution, biotransformation and excretion of drugs. To cover all these facets of drug metabolism in a single text is a voluminous task and therefore we have focused primarily on the biotransformation aspects of the subject.
Drug Metabolism
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Author : Corina Ionescu
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-02-28
Drug Metabolism written by Corina Ionescu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-02-28 with Medical categories.
Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
An Introduction To Pharmacokinetics
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Author : B. Clark
language : en
Publisher: Wiley-Blackwell
Release Date : 1991-01-15
An Introduction To Pharmacokinetics written by B. Clark and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-01-15 with Medical categories.
The first edition of this book was described by the British Medical Journal as `a concise and clear account of the basics of pharmacokinetics which could not be faulted in any way.' Since it was published in 1981, there has been an enormous increase in the quantity of published pharmacokinetic data. And, in addition to the great interest in pharmacokinetics in medicine, there is now a greatly increased reliance upon pharmacokinetics to help in the design and interpretation of animal toxicity tests carried out to evaluate drug safety. This expansion of the data and interest in the subject reinforces the need for this simple introductory text aimed at students of pharmacy, pharmacology, human or veterinary medicine, toxicology and drug metabolism.
Drug Metabolism And Pharmacokinetics Quick Guide
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Author : Siamak Cyrus Khojasteh
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-04-07
Drug Metabolism And Pharmacokinetics Quick Guide written by Siamak Cyrus Khojasteh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-07 with Medical categories.
Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.
Drug Metabolism Handbook
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Author : Ala F. Nassar
language : en
Publisher: John Wiley & Sons
Release Date : 2022-11-18
Drug Metabolism Handbook written by Ala F. Nassar and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-18 with Medical categories.
A comprehensive explanation of drug metabolism concepts and applications in drug development and cancer treatment In the newly revised second edition of Drug Metabolism Handbook: Concepts and Applications in Cancer Research, a distinguished team of researchers delivers an incisive and robust exploration of the drug metabolism system and a well-illustrated and detailed explanation of the latest tools and techniques used in the research, pharmacology, and medicine. The book discusses the creation of new molecular entities, drug development, troubleshooting, and other highly relevant concepts, guiding readers through new applications in pharmaceutical research, development, and assessment. The latest edition offers updated content on metabolism basics and the application of a variety of new techniques to cancer treatment, including mass spectrometry, imaging, metabolomics, and immunotherapy. It also offers in-depth case studies highlighting the role of metabolism in drug development. Readers will also benefit from: A thorough introduction to drug metabolism, including a historical perspective, factors affecting metabolism, and biotransformations in drug metabolism Comprehensive discussions of technologies for in vitro and in vivo studies, including mass spectrometry and accelerating metabolite identification with mass spectrometry In-depth explorations of drug interactions, including discussions of enzyme inhibition and the characterization of cytochrome P450 mechanism-based inhibition Fulsome treatments of drug toxicity, including the role of drug metabolism in toxicity, and allergic reactions to drugs Perfect for medicinal chemists, pharmaceutical scientists, and toxicologists, Drug Metabolism Handbook: Concepts and Applications in Cancer Research, Second Edition will also earn a place in the libraries of analytical chemists and drug discovery professionals.
Drug Metabolism In Drug Design And Development
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Author : Donglu Zhang
language : en
Publisher: John Wiley & Sons
Release Date : 2007-11-16
Drug Metabolism In Drug Design And Development written by Donglu Zhang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-16 with Science categories.
The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.
Introduction To Drug Disposition And Pharmacokinetics
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Author : Stephen H. Curry
language : en
Publisher: John Wiley & Sons
Release Date : 2017-01-30
Introduction To Drug Disposition And Pharmacokinetics written by Stephen H. Curry and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-30 with Science categories.
The application of knowledge of drug disposition, and skills in pharmacokinetics, are crucial to the development of new drugs and to a better understanding of how to achieve maximum benefit from existing ones. The book takes the reader from basic concepts to a point where those who wish to will be able to perform pharmacokinetic calculations and be ready to read more advanced texts and research papers. The book will be of benefit to students of medicine, pharmacy, pharmacology, biomedical sciences and veterinary science, including those who have elected to study the topic in more detail, such as via electives and special study modules. It will be of benefit to those involved in drug discovery and development, pharmaceutical and medicinal chemists, as well as budding toxicologists and forensic scientists who require the appropriate knowledge to interpret their findings and as an introductory text for clinical pharmacologists. Early chapters describe the basic principles of the topic while the later ones illustrate the application of those principles to modern approaches to drug development and clinical use. Full colour illustrations facilitate the learning experience and supporting material for course leaders and students can be found on the Companion Web Site "Another book on PK? Yes and there should be and it should be DD & PK. It is good, unique, and does fill a currently unmet need for those working in the xenobiotic arena. DD & PK is just like the perfect mystery novel—the one “you just can’t put down.” However, unlike a mystery novel which requires only one reading to find the answer, the reader of DD & PK will learn more than an answer to a single question. The reader will find many solutions to a wide variety of mysterious problems associated with the time course and actions of xenobiotics." —International Journal of Toxicology, John A. Budny, PhD, President, PharmaCal, Ltd, 2018 "This book has many innovations that make a welcome addition to the bookshelves of a wide range of pharmaceutical scientists. The effective use of figures and tables to summarize and clarify a wide range of issues is to be commended, as are the learning objectives at the start of the chapter coupled with the summary at the end providing a succinct way in understanding the objectives of the chapter and together with links to a website provides accessibility for all from the neophyte pharmacokineticist to the consultant physician. A book all in the Pharma industry should be aware of." —Int. J. of Pharmacokinetics, Howard M. Hill, ResolvPharma, 2018 "Overall, Introduction to Drug Disposition and Pharmacokinetics offers its readership an in-depth view of classic pharmacokinetic concepts. This book would be an excellent choice for a pharmacokinetics elective or as an adjunctive text for an introductory course. This book reviews a wide array of clinically relevant topics and encourages the reader to apply the knowledge gained to all medi-cations. A robust and varied amount of online material is provided to enhance understanding and encourage discussion. It is likely that all readers, novice or experienced pharmacists, would find value in this textbook." — Currents in Pharmacy Teaching and Learning, Milena McLaughlin, Midwestern University Chicago College of Pharmacy, 2018 "In summary, this is an excellent textbook for students new to the field of pharmaceutics and medical, pharmacy, and veterinary students, particularly those who envision a career in drug development research in either academia or industry." —Veterinary Pathology Review, John K. Amory, University of Washington, 2018