Introduction To Population Pharmacokinetic Pharmacodynamic Analysis With Nonlinear Mixed Effects Models
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Introduction To Population Pharmacokinetic Pharmacodynamic Analysis With Nonlinear Mixed Effects Models
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Author : Joel S. Owen
language : en
Publisher: John Wiley & Sons
Release Date : 2014-07-08
Introduction To Population Pharmacokinetic Pharmacodynamic Analysis With Nonlinear Mixed Effects Models written by Joel S. Owen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Medical categories.
This book provides a user-friendly, hands-on introduction to the Nonlinear Mixed Effects Modeling (NONMEM) system, the most powerful tool for pharmacokinetic / pharmacodynamic analysis. • Introduces requisite background to using Nonlinear Mixed Effects Modeling (NONMEM), covering data requirements, model building and evaluation, and quality control aspects • Provides examples of nonlinear modeling concepts and estimation basics with discussion on the model building process and applications of empirical Bayesian estimates in the drug development environment • Includes detailed chapters on data set structure, developing control streams for modeling and simulation, model applications, interpretation of NONMEM output and results, and quality control • Has datasets, programming code, and practice exercises with solutions, available on a supplementary website
Introduction To Population Pharmacokinetic Pharmacodynamic Analysis With Nonlinear Mixed Effects Models
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Author : Joel S. Owen
language : en
Publisher: John Wiley & Sons
Release Date : 2014-06-19
Introduction To Population Pharmacokinetic Pharmacodynamic Analysis With Nonlinear Mixed Effects Models written by Joel S. Owen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-19 with Medical categories.
This book provides a user-friendly, hands-on introduction to the Nonlinear Mixed Effects Modeling (NONMEM) system, the most powerful tool for pharmacokinetic / pharmacodynamic analysis. • Introduces requisite background to using Nonlinear Mixed Effects Modeling (NONMEM), covering data requirements, model building and evaluation, and quality control aspects • Provides examples of nonlinear modeling concepts and estimation basics with discussion on the model building process and applications of empirical Bayesian estimates in the drug development environment • Includes detailed chapters on data set structure, developing control streams for modeling and simulation, model applications, interpretation of NONMEM output and results, and quality control • Has datasets, programming code, and practice exercises with solutions, available on a supplementary website
Pharmacokinetic Pharmacodynamic Modeling And Simulation
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Author : Peter L. Bonate
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-07-01
Pharmacokinetic Pharmacodynamic Modeling And Simulation written by Peter L. Bonate and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-01 with Medical categories.
This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated.
Pharmacokinetic Pharmacodynamic Modeling And Simulation
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Author : Peter L. Bonate
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-05-14
Pharmacokinetic Pharmacodynamic Modeling And Simulation written by Peter L. Bonate and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-14 with Medical categories.
A natural hierarchy exists in pharmacokinetic-pharmacodynamic modeling culminating in population pharmacokinetic models, which are a specific type of nonlinear mixed effects model. The purpose of this book is to present through theory and example how to develop pharmacokinetic models, both at an individual and population level. In order to do so, however, one must first understand linear models and then build to nonlinear models followed by linear mixed effects models and then ultimately nonlinear mixed effects models. This book develops in that manner – each chapter builds upon previous chapters by first presenting the theory and then illustrating the theory using published data sets and actual data sets that were used in the development of new chemical entities collected by the author during his years in industry. A key feature of the book is the process of modeling. Most books and manuscripts often present the final model never showing how the model evolved. In this book all examples are presented in an evolutionary manner.
Fuzzy Logic In Intelligent System Design
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Author : Patricia Melin
language : en
Publisher: Springer
Release Date : 2017-09-30
Fuzzy Logic In Intelligent System Design written by Patricia Melin and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-30 with Technology & Engineering categories.
This book describes recent advances in the use of fuzzy logic for the design of hybrid intelligent systems based on nature-inspired optimization and their applications in areas such as intelligent control and robotics, pattern recognition, medical diagnosis, time series prediction and optimization of complex problems. Based on papers presented at the North American Fuzzy Information Processing Society Annual Conference (NAFIPS 2017), held in Cancun, Mexico from 16 to 18 October 2017, the book is divided into nine main parts, the first of which first addresses theoretical aspects, and proposes new concepts and algorithms based on type-1 fuzzy systems. The second part consists of papers on new concepts and algorithms for type-2 fuzzy systems, and on applications of type-2 fuzzy systems in diverse areas, such as time series prediction and pattern recognition. In turn, the third part contains papers that present enhancements to meta-heuristics based on fuzzy logic techniques describing new nature-inspired optimization algorithms that use fuzzy dynamic adaptation of parameters. The fourth part presents emergent intelligent models, which range from quantum algorithms to cellular automata. The fifth part explores applications of fuzzy logic in diverse areas of medicine, such as the diagnosis of hypertension and heart diseases. The sixth part describes new computational intelligence algorithms and their applications in different areas of intelligent control, while the seventh examines the use of fuzzy logic in different mathematic models. The eight part deals with a diverse range of applications of fuzzy logic, ranging from environmental to autonomous navigation, while the ninth covers theoretical concepts of fuzzy models
Methods And Application In Drug Metabolism And Transport 2021
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Author : Ren-ai Xu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-01
Methods And Application In Drug Metabolism And Transport 2021 written by Ren-ai Xu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-01 with Science categories.
Physico Chemical Aspects Of Dosage Forms And Biopharmaceutics
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Author : Amit Kumar Nayak
language : en
Publisher: Elsevier
Release Date : 2024-08-09
Physico Chemical Aspects Of Dosage Forms And Biopharmaceutics written by Amit Kumar Nayak and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-09 with Medical categories.
Physico-Chemical Aspects of Dosage Forms and Biopharmaceutics: Recent and Future Trends in Pharmaceutics, Volume Two explores aspects of pharmaceutics with an original approach that focuses on technology, novelties and future trends. The field of pharmaceutics is highly dynamic and rapidly expanding day-by-day, so it demands a variety of amplified efforts for designing and developing pharmaceutical processes and formulation strategies. Readers will find practical information for conducting research in pharmaceutics that is ideal for researchers in academia and industry as well as advanced graduate students in pharmaceutics. In addition, the book discusses the most recent developments in biopharmaceutics, including important and exciting areas such as solubility of drugs, pharmaceutical granulation, routes of drug administration, drug absorption, bioavailability and bioequivalence. - Provides extensive details on the most recent developments in biopharmaceutics - Contains contributions from leading experts from academia, research, industry and regulatory agencies - Includes high quality illustrations, flow charts and tables for easier understanding of the concepts - Discusses practical examples and research case studies
Putting Pharmacokinetics And Pharmacodynamics To Work In Drug Discovery
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Author : Emile P. Chen
language : en
Publisher: John Wiley & Sons
Release Date : 2025-05-28
Putting Pharmacokinetics And Pharmacodynamics To Work In Drug Discovery written by Emile P. Chen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-28 with Medical categories.
Develop drugs with a greater understanding of their bodily impact Pharmaceutical scientists in the fields of pharmacokinetics and pharmacodynamics study how drugs behave in the body and how they reach their site of action to exert their intended pharmacological activities. Drug discovery stands to benefit enormously from the timely application of pharmacokinetics and pharmacodynamics in order to make informed decisions and solve practical problems. Putting Pharmacokinetics and Pharmacodynamics to Work in Drug Discovery bridge between scientific concepts and practical industrial practice by bringing these principles to bear on every stage of the drug discovery process. Beginning with target identification and moving through each subsequent decision point including high throughput screening, hit-to-lead, lead optimization and candidate selection. The book offers a comprehensive guide to minimizing attrition, reducing costs, and more. The result is an invaluable tool in developing smarter and more effective drug discovery processes. Putting Pharmacokinetics and Pharmacodynamics to Work in Drug Discovery readers will also find: A work designed to make scientific principles accessible to pharmaceutical scientists in diverse areas, not just pharmacokinetists or DMPK scientists Industrial examples, both positive and negative, showing pharmacokinetic and pharmacodynamic principles at work Interactive exercises at the end of each section to encourage holistic and integrated thinking Putting Pharmacokinetics and Pharmacodynamics to Work in Drug Discovery is ideal for any researchers or professionals involved in drug discovery and development, including medicinal chemists, biopharmaceutics scientists, clinicians, project leaders, and many others.
Neuropsychopharmacology
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Author : Jahangir Moini
language : en
Publisher: Elsevier
Release Date : 2023-05-10
Neuropsychopharmacology written by Jahangir Moini and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-10 with Medical categories.
Neuropsychopharmacology reviews the principles of pharmacology with a focus on the central nervous system and autonomic nervous system. Beyond autonomic and central nervous system pharmacology, this volume uniquely discusses psychiatric disorders and the pharmacological interventions that are available for conditions including depression, schizophrenia and anxiety disorders. With a focus on these specific body systems, readers will see end-of-chapter questions that offer real-world case studies, as well as multiple-choice questions for further learning. Beneficial features and content also include two extensive examination tests, which each contain 100 questions for better learning or to be used in teaching, and a glossary. Helpful appendices cover high-alert medications and toxicology effects on the nervous system. Each chapter will contain classifications of medications, pharmacokinetics, mechanism of action, clinical indications and toxicities. - Describes pharmacology principles pertaining to the central and autonomic nervous system - Identifies pharmacological interventions for psychiatric disorders including current evidence-based interventions for depression, schizophrenia and anxiety disorders - Features chapter outlines, end-of-chapter questions, real-world case studies and examinations for deeper learning or teaching
Exploring Computational Pharmaceutics
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Author : Defang Ouyang
language : en
Publisher: John Wiley & Sons
Release Date : 2024-11-12
Exploring Computational Pharmaceutics written by Defang Ouyang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-12 with Science categories.
Provides an extensive and up-to-date overview of the theory and application of computational pharmaceutics in the drug development process Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0 introduces a variety of current and emerging computational techniques for pharmaceutical research. Bringing together experts from academia, industry, and regulatory agencies, this edited volume also explores the current state, key challenges, and future outlook of computational pharmaceutics while encouraging development across all sectors of the field. Throughout the text, the authors discuss a wide range of essential topics, from molecular modeling and process simulation to intelligent manufacturing and quantitative pharmacology. Building upon Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0, this new edition provides a multi-scale perspective that reveals the physical, chemical, mathematical, and data-driven details of pre-formulation, formulation, process, and clinical studies, in addition to in vivo prediction in the human body and precision medicine in clinical settings. Detailed chapters address both conventional dosage forms and the application of computational technologies in advanced pharmaceutical research, such as dendrimer-based delivery systems, liposome and lipid membrane research, and inorganic nanoparticles. A major contribution to the development and promotion of computational pharmaceutics, this important resource: Discusses the development track, achievements, and prospects of computational pharmaceutics Presents multidisciplinary research to help physicists, chemists, mathematicians, and computer scientists locate problems in the field of drug delivery Covers a wide range of technologies, including complex formulations for water-insoluble drugs, protein/peptide formulations, nanomedicine, and gene delivery systems Focuses on the application of cutting-edge computational technologies and intelligent manufacturing of emerging pharmaceutical technologies Includes a systematic overview of computational pharmaceutics and Pharma 4.0 to assist non-specialist readers Covering introductory, advanced, and specialist topics, Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0 is an invaluable resource for computational chemists, computational analysts, pharmaceutical chemists, process engineers, process managers, and pharmacologists, as well as computer scientists, medicinal chemists, clinical pharmacists, material scientists, and nanotechnology specialists working in the field.