Involvements Of Trp Channels And Oxidative Stress In Pain
DOWNLOAD
Download Involvements Of Trp Channels And Oxidative Stress In Pain PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Involvements Of Trp Channels And Oxidative Stress In Pain book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Involvements Of Trp Channels And Oxidative Stress In Pain
DOWNLOAD
Author : Jose A. Pariente
language : en
Publisher: Frontiers Media SA
Release Date : 2018-10-05
Involvements Of Trp Channels And Oxidative Stress In Pain written by Jose A. Pariente and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-05 with categories.
Undoubtedly, pain conditions the quality of life of millions of people worldwide suffering a wide range of diseases. Major research efforts are being made by the international scientific community to determine the mechanisms underlying nociception. Growing evidence points out a complex network including oxidative and nitrosative stress, inflammatory response and cation signaling. In this sense, transient receptor potential (TRP) channels have attracted researchers’ attention. Expression levels are very different in tissues and cells mediating a myriad of processes in our organism. At the neurological level, it has been observed that the expression levels of four TRP channels (TRPA1, TRPM2, TRPV1, and TRPV4) are high in neurons related to nociception, including dorsal root ganglion and trigeminal ganglia neurons. For this reason, this research field promises to shed light on this intricated matrix linking oxidative stress, calcium signaling (via TRP channels), and inflammatory signals in different pain modalities, including neuropathic pain and chemotherapy-induced peripheral pain. In such a way, all this intense research activity will enable us to design individual and rational treatment strategies for pain relief, such as the use of molecular neurosurgery.
Involvements Of Trp Channels Oxidative Stress And Apoptosis In Neurodegenerative Diseases
DOWNLOAD
Author : Mustafa Naziroglu
language : en
Publisher: Frontiers Media SA
Release Date : 2021-05-03
Involvements Of Trp Channels Oxidative Stress And Apoptosis In Neurodegenerative Diseases written by Mustafa Naziroglu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-03 with Science categories.
Innovative Medicine
DOWNLOAD
Author : Kazuwa Nakao
language : en
Publisher: Springer
Release Date : 2015-10-13
Innovative Medicine written by Kazuwa Nakao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-13 with Science categories.
This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Trp Channels As Therapeutic Targets
DOWNLOAD
Author : Arpad Szallasi
language : en
Publisher: Academic Press
Release Date : 2015-04-09
Trp Channels As Therapeutic Targets written by Arpad Szallasi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-09 with Medical categories.
TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings. Contains comprehensive coverage of TRP channels as therapeutic targets, from emerging clinical indications to completed clinical trials Discusses TRP channels as validated targets, ranging from obesity and diabetes through cancer and respiratory disorders, kidney diseases, hypertension, neurodegenerative disorders, and more Provides critical analysis of the complications and side effects that have surfaced during clinical trials, offering evidence-based suggestions for overcoming them
Itch
DOWNLOAD
Author : E. Carstens
language : en
Publisher: CRC Press
Release Date : 2014-02-25
Itch written by E. Carstens and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-25 with Science categories.
Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
Transient Receptor Potential Channels
DOWNLOAD
Author : Md. Shahidul Islam
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-02-04
Transient Receptor Potential Channels written by Md. Shahidul Islam and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-04 with Medical categories.
Transient Receptor Potential Channels offers a unique blend of thoughtfully selected topics ranging from the structural biology of this fascinating group of ion channels to their emerging roles in human diseases. This single book covers TRP channels of yeasts, flies, fishes frogs and humans. And from the biophysics of primary thermo-sensory events in cells to the thermosensation at whole organism level, from physiology of pain to the development of pain-killers, from psychiatric illnesses to cancers, from skin cells to sperms, from taste buds to testes, from established facts to heated debates, this book contains something for every TRP enthusiasts, beginner and expert alike. It includes crucial background information, critical analysis of cutting edge research, and ideas and thoughts for numerous testable hypotheses. It also shows directions for future research in this highly dynamic field. It is a book readers will be just as eager to give to others as keep for themselves.
Systems Biology Of Free Radicals And Antioxidants
DOWNLOAD
Author : Ismail Laher
language : en
Publisher: Springer
Release Date : 2014-06-16
Systems Biology Of Free Radicals And Antioxidants written by Ismail Laher and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-16 with Medical categories.
The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.
Advances In Pain Research Mechanisms And Modulation Of Chronic Pain
DOWNLOAD
Author : Bai-Chuang Shyu
language : en
Publisher: Springer
Release Date : 2018-10-10
Advances In Pain Research Mechanisms And Modulation Of Chronic Pain written by Bai-Chuang Shyu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-10 with Medical categories.
This book summarizes the latest advances in pain research. All the chapters were contributed by speakers from Asian Pain Symposium (APS) on Acute and Chronic Pain, which was held in Taipei in 2017. Founded in Kyoto, Japan in 2000, the APS serves as a platform for scientists to present recent findings in pain research and discuss research orientation in this field. APS 2017 focused on novel strategies for pain treatment. Written by experts from various disciplines, from molecular to functional, and from basic to clinic studies, this book is composed of 18 review articles on the physiology and pathology of pain in these research fields. Specific topics include circuitry, neurotransmitter, physiology, behavior, neuropathology, pharmacology, and the treatments for neuropathic pain disorders. The book is a valuable resource for researchers and graduate students in pain medicine and neuroscience.
Redox
DOWNLOAD
Author : Mohammed Awad Ali Khalid
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-09-06
Redox written by Mohammed Awad Ali Khalid and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-06 with Science categories.
Redox reactions are central to the major element cycling, many cell cycles, many chemisorption and physisorption processes, trace element mobility from rocks and sediments toward wells, aquifers, trace element toxicity toward life forms, and most remediation schemes including water treatments; over the last three decades, the field has attracted a lot of scientists, and a great deal of researches has been done in redox chemistry. This book provides a very broad overview of the state of the art of understanding redox processes, which starts with giving a concise introduction that describes the origin, historical background, and the development of the redox definitions. The book is organized into two sections that include ten chapters and introduces, in Section 1, generalized electron balance theory and its applications in electrolytic redox systems, redox-active molecules and its applications in device memory, fundamentals and applications of flow batteries and their integration into antidirect current, and donor acceptor titrations of displacement and electronic transference. Section 2 introduces redox in biological processes, including roles of reactive oxygen species in respiration, metabolism, and regulations, and redox in physiological processes as redox-sensitive TRP channels TRPA1 and TRPM2. All chapters are written by different authors (with the exception of Chapter 1 [Introduction]). This clearly reflects the broad range of topics that have been covered by experts in the field.
Ion Channels In Health And Sickness
DOWNLOAD
Author : Fatima Shad Kaneez
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-10-10
Ion Channels In Health And Sickness written by Fatima Shad Kaneez and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-10 with Science categories.
Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.