Ion Channels Channel Biochemistry Reconstitution And Function
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Ion Channels Channel Biochemistry Reconstitution And Function
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Author :
language : en
Publisher: Academic Press
Release Date : 2021-05-29
Ion Channels Channel Biochemistry Reconstitution And Function written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-29 with Science categories.
Ion Channels Part A, Volume 651 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of new developments on the topic. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Enzymology series
Ion Channel Reconstitution
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Author : C. Miller
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-09
Ion Channel Reconstitution written by C. Miller and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-09 with Science categories.
It is now over 30 years since the idea of ion-conducting pores burst on the elec trophysiological scene, 15 years since these were generalIy realized to be mem brane-spanning proteins, and 10 years since the first observations of single ion channels from higher organisms were made. During the past 5 years, several integral membrane channel proteins have been purified in a functionalIy competent state: the nicotinic acetylcholine receptor, the Na + channel, mitochondrial "VDAC," and a variety of porins. The stage is thus set to attack ion channels in the same ways that biochemists have been attacking enzymes for decades: isolation folIowed by functional analysis in as simple a system as possible, with a view towards understanding the molecular mechanisms ofthe protein's behavior and how this is related to the underlying molecular structure. This is always a daunting task, alI the more so with ion channels because of our still primitive and scanty understanding of channel structures and because of the difficulty in iso lating functionally active channel proteins. In this volume, which can be considered a biochemically slanted companion to Sakmann and Neher's Single-Channel Recording, I have tried to present a view of the current landscape of ion-channel reconstitution. These chapters illustrate not only the different approaches and techniques of the major practitioners of ion channel reconstitution but, as importantly, the varied motivations for doing this kind of work.
Molecular Biology Of Neuroreceptors And Ion Channels
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Author : Alfred Maelicke
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Molecular Biology Of Neuroreceptors And Ion Channels written by Alfred Maelicke and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
This workshop was the second of this series held on the island of santorini in the Cycladic Sea. The first one ("Mechanism of Action of the Nicotinic Acetylcholine Receptor", NATO ASI Se ries H, vol. 10) took place in May 1986 and focused on what was at the time the best studied of all neuroreceptors. This second one, held only two years later, demonstrates the im mense progress achieved since then in the field of neurorecep tors and ion channels. Molecular cloning techniques have now made available the primary structures of a whole array of ion channel proteins, and this in turn has shed light on some gen eral principles of the structure-function relationships of these central elements of intercellular communication. The purpose of this workshop was to explore the common ele ments in gene and protein structure of already cloned ion channel proteins, and to assess the status of other cloning projects in progress. It explicitly focused on very recently published and unpublished results. All participants kept to these goals thereby demonstrating the very value of such work shops for the progress of science.
Ionic Channels In Cells And Model Systems
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Author : Ramón Latorre
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Ionic Channels In Cells And Model Systems written by Ramón Latorre and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
This book is based on a series of lectures for a course on ionic channels held in Santiago, Chile, on November 17-20, 1984. It is intended as a tutorial guide on the properties, function, modulation, and reconstitution of ionic channels, and it should be accessible to graduate students taking their first steps in this field. In the presentation there has been a deliberate emphasis on the spe cific methodologies used toward the understanding of the workings and function of channels. Thus, in the first section, we learn to "read" single channel records: how to interpret them in the theoretical frame of kinetic models, which information can be extracted from gating currents in re lation to the closing and opening processes, and how ion transport through an open channel can be explained in terms of fluctuating energy barriers. The importance of assessing unequivocally the origin and purity of mem brane preparations and the use of membrane vesicles and optical tech niques in the stUGY of ionic channels are also discussed in this section. The patch-clamp technique has made it possible to study ion channels in a variety of different cells and tissues not amenable to more conven tional electrophysiological methods. The second section, therefore, deals with the use of this technique in the characterization of ionic channels in different types of cells, ranging from plant protoplasts to photoreceptors.
Planar Lipid Bilayers Blm S And Their Applications
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Author : H.T. Tien †
language : en
Publisher: Elsevier
Release Date : 2003-02-27
Planar Lipid Bilayers Blm S And Their Applications written by H.T. Tien † and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-02-27 with Science categories.
The lipid bilayer is the most basic structural element of cell membranes. A wide range of topics are covered in this volume, from the origin of the lipid bilayer concept, to current applications and experimental techniques. Each chapter in this volume is self-contained and describes a group's research, providing detailed methodology and key references useful for researchers. Lipid bilayer research is of great interest to many because of it's interdisciplinary nature.·Provides an overview of decades of research on the lipid bilayer·38 contributed chapters, by leading scientists, cover a wide range of topics in one authoritative volume·Book coincides with 40th anniversary of BLM
Molecular Biology Of Membrane Transport Disorders
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Author : Thomas E. Andreoli
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Molecular Biology Of Membrane Transport Disorders written by Thomas E. Andreoli and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
When the six of us gathered to start planning for what was to be the Third Edition of Physiology of Membrane Disorders, it was clear that since 1986, when the Second Edition appeared, the field had experienced the dawning of a new era dominated by a change in focus from phenomenology to underlying mechanisms propelled by the power of molecular biology. In 1985, detailed molecular information was available for only three membrane transporters: the lac permease, bacterial rhodopsin, and the acetylcholine receptor. During the decade that has since elapsed, almost all of the major ion channels and transport proteins have been cloned, sequenced, mutagenized, and expressed in homologous as well as heterologous cells. Few, if any, of the transporters that were identified during the previous era have escaped the probings of the new molecular technologies and, in many instances, considerable insight has been gained into their mechanisms of function in health and disease. Indeed, in some instances novel, unexpected transporters have emerged that have yet to have their functions identified. The decision to adopt the new title Molecular Biology of Membrane Transport Disorders was a natural outgrowth of these considerations.
Advances In Planar Lipid Bilayers And Liposomes
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Author : A. Leitmannova Liu
language : en
Publisher: Academic Press
Release Date : 2011-08-09
Advances In Planar Lipid Bilayers And Liposomes written by A. Leitmannova Liu and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-09 with Science categories.
Advances in Planar Lipid Bilayers and Liposomes, Volume 6, continues to include invited chapters on a broad range of topics, covering both main arrangements of the reconstituted system, namely planar lipid bilayers and spherical liposomes. The invited authors present the latest results in this exciting multidisciplinary field of their own research group. Many of the contributors working in both fields over many decades were in close collaboration with the late Prof. H. Ti Tien, the founding editor of this book series. There are also chapters written by some of the younger generation of scientists included in this series. This volume keeps in mind the broader goal with both systems, planar lipid bilayers and spherical liposomes, which is the further development of this interdisciplinary field worldwide. - Contributions from newcomers and established and experienced researchers - Exploring theoretically and experimentally the planar lipid bilayer systems and spherical liposomes - This volume is dedicated to mark the Bilayer Lipid Membranes 45th anniversary
Artificial And Reconstituted Membrane Systems
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Author : J. Robin Harris
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Artificial And Reconstituted Membrane Systems written by J. Robin Harris and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
This collection of 11 chapters is devoted to a survey of artificial and reconsti tuted membrane systems. These are fundamental themes and areas of great current importance in membrane biochemistry. They also relate well to the founding concept of this series, namely, to present studies that progressively work toward and provide us with an "integrated view of the cell. " In this volume, it is the application of a wide range of physiochemical and biochemi cal techniques to the study of membrane lipids and proteins which serves to demonstrate the significant progress that has been made in this field over the past 25 years. From the understanding of simplified artificial systems, it is hoped that it will ultimately be possible to gain a more accurate understanding of natural biological membranes, in all their diversity. This book is an appropriate successor to Volume 13 of the series, which deals with fluorescence studies on biological membranes. Indeed, the present chapter by Lesley Davenport and colleagues was originally due for inclusion in Volume 13, but has been held over for inclusion in this volume, where it integrates remarkably well with the other topics. The extremely varied and interesting contents of this volume are now briefly outlined. In Chapter I, Jacqueline A. Reynolds and Darrell R. McCaslin pres ent a pertinent survey of the interaction of detergents with membrane lipids and proteins, together with an assessment of the reconstitution process.
Structure And Properties Of Cell Membrane Structure And Properties Of Cell Membranes
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Author : Benga
language : en
Publisher: CRC Press
Release Date : 2018-01-18
Structure And Properties Of Cell Membrane Structure And Properties Of Cell Membranes written by Benga and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-18 with Science categories.
This book provides in-depth presentations in membrane biology by specialists of international repute. The volumes examine world literature on recent advances in understanding the molecular struc-ture and properties of membranes, the role they play in cellular physiology and cell-cell interactions, and the alterations leading to abnormal cells. Illustrations, tables, and useful appendices com-plement the text. Those professionals actively working in the field of cell membrane investigations as well as biologists, biochemists, biophysicists, physicians, and academicians, will find this work beneficial.
Energy Research Abstracts
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Author :
language : en
Publisher:
Release Date : 1985
Energy Research Abstracts written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Power resources categories.