Iron In Central Nervous System Disorders

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Iron In Central Nervous System Disorders

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Author : Peter Riederer
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Iron In Central Nervous System Disorders written by Peter Riederer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

The role of the metals copper, zinc, magnesium, lead, manganese, mercury, lithium and aluminium in neuropsychiatric disease are well known and has been discussed on several occasions. Yet little attention has been paid to iron, the most abundant transitional metal in the body and the earth's crust. Iron plays a major role as a cofactor of numerous metabolic enzymes, it is important for DNA and protein synthesis, and has a crucial role in the oxygen carrying capacity of haemoglobin. Some of the most devastating diseases of systemic organs are associated with abnormal iron metabolism. Yet only very recently its role in the central nervous system has been considered. Thus nutritional iron defi ciency and iron overload afflict some 500-600 million people. It is also well recognized that too little or too much iron can produce profound effects on the metabolic state of the cell, and therefore the regulation of iron uptake and disposition is tightly relegated by the cell. Its transport into the cell and storage are handled by transferrin, ferritin and haemo siderin. Nowhere are these processes so well recognized as in the case of brain iron metabolism. Iron does not have ready access to the adult brain as it does to other tissues, since it does not cross the blood brain barrier (BBB). All the iron present in brain is deposited before the closure of BBB at an early age where it is sequestered and conserved. Therefore its turnover is extremely slow.

Iron In Central Nervous System Disorders

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Author : Peter Riederer
language : en
Publisher: Springer Verlag
Release Date : 1993-01-01

Iron In Central Nervous System Disorders written by Peter Riederer and has been published by Springer Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-01-01 with Medical categories.

Brain Iron Metabolism And Cns Diseases

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Author : Yan-Zhong Chang
language : en
Publisher: Springer Nature
Release Date : 2019-08-27

Brain Iron Metabolism And Cns Diseases written by Yan-Zhong Chang and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-27 with Medical categories.

This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.

Brain Iron Metabolism And Cns Diseases

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Author : Yan-Zhong Chang
language : en
Publisher:
Release Date : 2019

Brain Iron Metabolism And Cns Diseases written by Yan-Zhong Chang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Central nervous system categories.

This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.

Redox Active Metals In Neurological Disorders

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Author : Steven M. LeVine
language : en
Publisher:
Release Date : 2004

Redox Active Metals In Neurological Disorders written by Steven M. LeVine and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Chelation therapy categories.

Redox-active metals have been implicated in the pathogenesis of many neurological disorders. This volume presents developments and ideas related to the pathogenic roles of redox-active metals in the neurological diseases. Contributions dealing with therapeutic interventions that are directed at countering these pathogenic mechanisms are included.

Brain Iron Cross Talk

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Author : Wael Mohamed
language : en
Publisher: Springer Nature
Release Date : 2022-12-16

Brain Iron Cross Talk written by Wael Mohamed and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-16 with Medical categories.

This book explores the molecular mechanisms of iron hemostasis in the brain and discusses the cognitive and behavioral implications of iron deficiency. It presents the effect of iron dysregulation on neurophysiological mechanisms. The book provides an overview of iron metabolism and homeostasis at the cellular level and its regulation at the mRNA translation level. It emphasizes the importance of iron for brain development in fetal and early life in preterm infants. Further, it presents iron metabolism as a therapeutic target for novel pharmacological treatment against neurodevelopmental diseases and neurodegenerative disorders. It discusses the role of iron deficiency in sleep disorders and offers diagnosis and treatment of iron-related CNS diseases. Finally, it relates dysregulated expression of iron-related genes in brain tumors. ​​

Iron Deficiency Brain Biochemistry And Behavior

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Author : Ernesto Pollitt
language : en
Publisher: Raven Press (ID)
Release Date : 1982

Iron Deficiency Brain Biochemistry And Behavior written by Ernesto Pollitt and has been published by Raven Press (ID) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Behavior categories.

Abstract: Conference papers are presented for nutrition scientists which emphasize the reciprocal interaction of the investigator's experimental interest (e.g., cardiovascular physiology, behavior) and the choice of the appropriate independent variable whereby nutritional status is to be defined. The material is covered under 3 sections. The 1st deals with the role of metals, in general, and iron, specifically, in nervous system metabolism. Sufficiently detailed knowledge of these pathways should allow for predictions of the types of behavioral and affective changes that might accompany iron deficiency. The 2nd section addresses the critical issue of how the independent variable, iron status) should be defined. The last section includes descriptions of the most recent studies on the functional effects of iron deficiency in animals and humans. Examination of the types of functional deficits permit delineation of possible biochemical mechanisms whereby iron status might influence behavior. (wz).

Brain Behaviour And Iron In The Infant Diet

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Author : John Dobbing
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-14

Brain Behaviour And Iron In The Infant Diet written by John Dobbing and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-14 with Medical categories.

Iron deficiency in infancy is very widespread, even in developed countries and even when there is no general malnutrition. This book examines the question whether iron deficiency in early life leads to deleterious changes in brain and/or behavioural development. Each of the nine contributors comments critically on each of the other eight chapters, so that the book is very extensively peer-reviewed. The evidence is set out so that the reader may make his own informed judgement. Iron deficiency could very easily be prevented; this fact is of prime importance if such deficiency has long-lasting effects on human intellectual capacity and achievement.

Transferrin Ferritin And Iron In The Central And Peripheral Nervous System

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Author :
language : en
Publisher:
Release Date : 2002

Transferrin Ferritin And Iron In The Central And Peripheral Nervous System written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Nervous system categories.

Metal Ions And Neurodegenerative Disorders

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Author : Paolo Zatta
language : en
Publisher: World Scientific
Release Date : 2003

Metal Ions And Neurodegenerative Disorders written by Paolo Zatta and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.

Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer''s disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer''s, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena. Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on OC Metals and the Brain: From Neurochemistry to NeurodegenerationOCO (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa. This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy. Contents: Metal-Catalyzed Redox Activity in Neurodegenerative Disease (M A Taddeo et al.); Aluminum and Central Nervous System Morphology in Hemodialysis (E Reusche); Transition Metals, Oxidation, Lipoproteins, and Amyloid-: Major Players in Alzheimer''s Disease (A Kontush); Molecular Basis of Copper Transport: Cellular and Physiological Functions of Menkes and Wilson Disease Proteins (ATP7A and ATP7B) (D R Kramer et al.); Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis (M B Yim et al.); Copper and Prion Disease (J Sasson & D Brown); Metallothioneins in Neurodegeneration (M Aschner et al.); Iron and Neurodegeneration (S L Grab & J R Connor); Iron, Neuromelanin, and -Synuclein in Neuropathogenesis of Parkinson''s Disease (K L Double et al.); Iron and Epilepsy (W-Y Ong et al.); Role of Iron Metabolism in Multiple Sclerosis (M J Kotze et al.); Neuroprotective Effects of Lithium (S Ermidiou-Pollet & S Pollet); and other articles. Readership: Academics, graduate students and researchers in neurology, psychiatry, neuroscience and environmental health."