Islet Transplantation And Beta Cell Replacement Therapy
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Islet Transplantation And Beta Cell Replacement Therapy
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Author : A. M. James Shapiro
language : en
Publisher: CRC Press
Release Date : 2007-07-25
Islet Transplantation And Beta Cell Replacement Therapy written by A. M. James Shapiro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-25 with Medical categories.
Beta cell replacement through transplantation remains the only treatment option for Type 1 diabetes enabling restoration of near-physiological glucose levels without significant hypoglycemia. Outlining the most recent advances and research breakthroughs, this practical guide and reference work explores the impact of islet cell transplantation and b
Pancreas And Beta Cell Replacement
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Author : Wayne Hawthorne
language : en
Publisher: Academic Press
Release Date : 2022-04-21
Pancreas And Beta Cell Replacement written by Wayne Hawthorne and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-21 with Science categories.
Pancreas and Beta Cell Replacement is the inaugural volume of the Regenerative and Transplant Medicine series. The idea for this new book series spawned from the observation that the regenerative medicine field is progressing at such a fast pace that the way we currently think and practice transplant medicine is rapidly changing, faster than we could ever imagine. This series was therefore conceived to bring together experts from both the transplant and regenerative medicine fields, to share knowledge first, but also to introduce the transplant audience to the remarkable progress that has occurred in regenerative medicine over the past few decades. At the same time, we intend to illustrate to researchers and operators in the regenerative medicine field the numerous platforms that transplant medicine offers for the application of their technologies. To the publisher and the editors of this series and volumes there is no doubt that regenerative medicine will shape and define the future of transplant medicine. This volume focuses on pancreas and beta cell replacement and illustrates how progress in biomaterial sciences, stem cell biology, gene editing, cell, tissue and organ bioengineering and regeneration, along with advances in xenotransplantation are revolutionizing the field. Written by the world’s experts in the fields of pancreas, islet and xenotransplantation, as well as regenerative medicine, it represents a valuable educational tool for those in the fields of clinical transplantation, researchers in the field of regenerative medicine, transplant medicine, diabetes and immunology, as well as for medical and health science students, those in academia, the biotech industry and regulatory agencies working to advance the field. At the end of the book, it will become clear to the reader that beta cell replacement offers a vast array of platforms for the application of regenerative medicine technologies to transplant medicine. First volume in the Regenerative and Transplant Medicine series, focusing on the pancreas Includes an overview of the field, including developments of transplantation methods and techniques Builds on previous works and demonstrates how regenerative and transplant medicine work together to provide an increased ability to improve health care outcomes for individuals
Autologous Stem Cell Derived Beta Cells For Diabetes Cell Replacement Therapy
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Author : Kristina G. Maxwell
language : en
Publisher:
Release Date : 2021
Autologous Stem Cell Derived Beta Cells For Diabetes Cell Replacement Therapy written by Kristina G. Maxwell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
Autologous stem cell therapy is a promising treatment for patients with diabetes worldwide. Previous stem cell-derived [beta] (SC-[beta]) cell protocols were unable to efficiently differentiate multiple patient induced pluripotent stem cells (iPSCs) into stem cell-derived islets (SC-islets), containing insulin-secreting SC-[beta] cells. Recent updates targeting the actin cytoskeleton have enabled the differentiation of 14 diabetic and nondiabetic stem cell lines into SC-islets. We used genetic engineering, specifically CRISPR/Cas9, to correct the diabetes-causing mutation in stem cells from patients with Wolfram Syndrome. The genetically engineered SC-[beta] cells functioned and had a composition similar to nondiabetic SC-[beta] cells, unlike the unedited SC-[beta] cells generated from the patient which revealed insulin processing defects and low [beta] cell yields from the differentiation. In addition, the corrected SC-[beta] cells reversed diabetes in mice within 8 days of transplantation, whereas, the diseased SC-[beta] cells maintained hyperglycemic over 8 months. Single-cell RNA sequencing identified differences in the diseased and corrected SC-[beta] cells from patients and was also used to analyze transplanted SC-islets after 6 months in vivo. The transplanted SC-islets had a global transcriptome profile similar to adult human islets, compared to in vitro SC-islets which are comparable to juvenile human islets.These revelations in transplanted SC-islets led us to study the effect of host mouse sex, diabetic environment, transplantation site, and dose on maturation of SC-islets in mice. SC-islets were only able to reverse pre-existing diabetes in mice at the kidney capsule transplantation location with a dose of 5 million and 2 million SC-islet cells. Alternative intramuscular and subcutaneous, and lower doses of 0.75 million cells were unable to reverse diabetes. SC-islet maturation was dependent on mouse host sex and independent of the diabetic environment.Next, we defined the transcriptome profile and maturation of SC-islets, stem cell-derived pancreatic progenitors (SC-PPs), and primary cadaveric human islets transplanted under the kidney capsule in mice. SC-islets achieved similar human C-peptide levels compared to human islets in mouse serum after 18 weeks in vivo. SC-PPs were able to mature into SC-[beta] cells in vivo, yet the serum C-Peptide levels only rose to similar levels of SC-islets upon transplantation. Both SC-islets and SC-PPs prevented diabetes in mice following STZ induction. SC-PPs yielded a small portion of SC-[beta] and endocrine cells, and a large number of exocrine cells following in vivo maturation. The transplanted [beta] cells derived from SC-PPs and SC-islets had similar gene expression of [beta] and islet markers. However, there was differential expression of known [beta] cell maturation genes, revealing gene signatures specific to original transplanted cells.Overall, these studies confirm the ability of SC-islets to reverse diabetes in animal models and define the similarity of transplanted SC-islets to primary human islets. We report differences in transcriptome and maturation of transplanted cells based on cell type and other parameters. The work in this dissertation provides evidence that autologous cell therapy could provide a long term therapy for patients with diabetes.
Pancreas And Islet Transplantation
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Author : Nadey S. Hakim
language : en
Publisher:
Release Date : 2002
Pancreas And Islet Transplantation written by Nadey S. Hakim and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
Diabetes Mellitus is the principle cause of kidney failure and blindness in adults and leads to more cases of amputation and impotence than any other disease. It is one of the most common chronic diseases in childhood. The aims of pancreas or islet transplantation are to improve the quality of life of patients with insulin dependent diabetes mellitus and to ameliorate secondary complications. This book provides a comprehensive and international review of the recent advances in pancreas and islet transplantation. It covers surgical techniques, issues surrounding organ preservation, immunosuppression and the control of other complications, all of which contribute to the potential for such transplantations to evolve as the treatment of choice for insulin dependent diabetes. The editors have compiled a strong and international team of contribution authors. This book is essential reading for transplant surgeons and all those involved in researching or treating diabetes mellitus.
Transplantation Bioengineering And Regeneration Of The Endocrine Pancreas
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Author : Giuseppe Orlando
language : en
Publisher: Academic Press
Release Date : 2019-11-10
Transplantation Bioengineering And Regeneration Of The Endocrine Pancreas written by Giuseppe Orlando and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-10 with Science categories.
Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 2, sets a new standard in transplant and regenerative medicine. The book details the state-of-the-art in modern islet auto-transplantation, also discussing current progress in regenerative medicine research in diabetes medicine. Regenerative medicine is changing the premise of solid organ transplantation, hence this volume catalogs technologies being developed and methods being implemented. Bioengineering and regenerating beta cells, clinical pancreas and islet transplantation, tissue engineering, biomaterial sciences, stem cell biology and developmental biology are all addressed and applied directly to diabetes medicine. Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation Addresses imaging, treatment, scaffold technology, the use of stem cells to generate insulin, 3D printing, and more Offers an update on the progress of regenerative medicine research aimed at beta cell replacement for the treatment of diabetes
Pluripotent Stem Cell Therapy For Diabetes
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Author : Lorenzo Piemonti
language : en
Publisher: Springer Nature
Release Date :
Pluripotent Stem Cell Therapy For Diabetes written by Lorenzo Piemonti and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Elucidating The Function Of Transplanted Islets Of Langerhans And Predicting Their Ability To Reverse Diabetes
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Author : Andrew R. Pepper
language : en
Publisher:
Release Date : 2012
Elucidating The Function Of Transplanted Islets Of Langerhans And Predicting Their Ability To Reverse Diabetes written by Andrew R. Pepper and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Type 1 diabetics require daily injections of exogenous insulin to control hyperglycemia. Unfortunately, patients are still plagued by vascular and hypoglycemic complications. Beta cell replacement therapy by either whole organ pancreas or islet transplantation has been shown to restore carbohydrate control to these patients. A major barrier to successful islet transplantation is the lack of a reliable pre-transplant assay of post-transplant function thus providing an objective measure of whether a particular islet isolation should be transplanted. Such an assay would also prove to be a valuable tool in the experimental evaluation of innovative islet isolation strategies and technologies. The initial aim of this graduate work was to study existing pre-transplant assays of islet function and to critically examine which if any are of value in predicting post-transplant reversal of diabetes. During the progress of the research while analyzing the data a novel methodology for predicting in vivo islet graft function from a simple in vitro evaluation emerged. This approach of ascertaining islet transplant function prior to engraftment incorporated the influence of islet morphology to the islet's ability to consume oxygen (OCR/II). The content of this thesis describes the evolution of this methodology from validating pre-existing rodent transplant models, to the discovery of this unique technique for predicting (porcine) islet function post-transplant. In addition herein, we describe the processes involved in translating these initial results performed in athymic mice, to clinically more relevant large animal studies through the development and subsequent testing of the methodology in porcine islet auto- and allograft transplant models. In all cases this OCR/II index proved to have a significantly greater predictive capacity of the ability of a given islet isolation to restore glucose control compared to other pre-transplant assays currently in use. Taken together these studies highlight data which demonstrate the efficacy of a rapid, simple, inexpensive in vitro test which predicts subsequent in vivo islet function, as exemplified and validated in a variety of transplant studies. In the near future it is hoped that the knowledge gained from this work will be employed in clinical islet transplantation.
Biobanking And Cryopreservation Of Stem Cells
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Author : Feridoun Karimi-Busheri
language : en
Publisher: Springer
Release Date : 2016-11-10
Biobanking And Cryopreservation Of Stem Cells written by Feridoun Karimi-Busheri and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-10 with Science categories.
Biobanking is considered to be one of the ten ideas changing the world with an estimated value of $45 billion by 2025. Despite the challenges, as the climate for innovation in the biobanking industry continues to flourish around the world, it is certain that amazing discoveries will emerge from this large-scale method of preserving and accessing human samples; biobanking is no longer just a place for collecting and storing samples. This book will cover a wide variety of subjects from across the future biobanking spectrum including scientific strategies, personalized medicine, regenerative medicine and stem cell challenges, disease surveillance, population genetics and innovative methods of biobanking.
Pancreatic Islet Cell Transplantation
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Author : Camillo Ricordi
language : en
Publisher: Landes Bioscience
Release Date : 1992
Pancreatic Islet Cell Transplantation written by Camillo Ricordi and has been published by Landes Bioscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
Intended for researchers and clinicians who work with cell transplantation, this text discusses the latest methods and gives an overall update of the major fields of islet transplantation. Included are reports of recent clinical trials on successful islet transplantation in humans.
Stem Cells From Hype To Real Hope
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Author : Khawaja Husnain Haider
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2018-12-17
Stem Cells From Hype To Real Hope written by Khawaja Husnain Haider and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-17 with Medical categories.
This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.