Joint Analysis Of Imaging And Genomic Data To Identify Associations Related To Cognitive Impairment
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Biocomputing 2017 Proceedings Of The Pacific Symposium
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Author : Russ B Altman
language : en
Publisher: World Scientific
Release Date : 2016-11-23
Biocomputing 2017 Proceedings Of The Pacific Symposium written by Russ B Altman and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-23 with Science categories.
The Pacific Symposium on Biocomputing (PSB) 2017 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2017 will be held on January 4 - 8, 2017 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2017 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's 'hot topics.' In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.
Joint Analysis Of Imaging And Genomic Data To Identify Associations Related To Cognitive Impairment
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Author : Elena Kaarina Szefer
language : en
Publisher:
Release Date : 2014
Joint Analysis Of Imaging And Genomic Data To Identify Associations Related To Cognitive Impairment written by Elena Kaarina Szefer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Both genetic variants and brain region abnormalities are recognized to play a role in cognitive decline. In this project, we explore the relationship between genome-wide variation and region-specific rates of decline in brain structure, as measured by magnetic resonanceimaging. The correspondence between rates of decline in brain regions and single nucleotide polymorphisms (SNPs) is investigated using data from the Alzheimer's Disease Neuroimaging Initiative 1 (ADNI-1), a study of Alzheimer's disease and mild cognitive impairment. In these data, the number of SNP and imaging biomarkers greatly exceeds the number of study subjects. To explore these data, we therefore look to modern multivariate statistical techniques that find sparse linear combinations of the two datasets having maximum correlation. These methods are particularly appealing because they greatly reduce the dimensions of the data, providing a low-dimensional representation of the data to explore. Regularization of the correlation structure through a "sparse" singular value decomposition makes multivariate analysis on a large set of biomarkers possible. Using sparse linear combinations of the two datasets also incorporates variable selection into the analysis, providing insight into which genetic variants are associated with cognitive decline. Resampling techniques are used to examine the validity of the results by exploring their reproducibility in independent test sets, and by assessing the stability of the variable selection.
Pacific Symposium On Biocomputing 2014
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Author : Russ B Altman
language : en
Publisher: World Scientific
Release Date : 2013-11-19
Pacific Symposium On Biocomputing 2014 written by Russ B Altman and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-19 with Science categories.
The Pacific Symposium on Biocomputing (PSB) 2014 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2014 will be held from January 3 - 7, 2014 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2014 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's “hot topics.” In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.
Applications And Methods In Genomic Networks
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Author : Kimberly Glass
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-01
Applications And Methods In Genomic Networks written by Kimberly Glass and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-01 with Science categories.
Cognitive Impairment In Schizophrenia
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Author : Philip D. Harvey
language : en
Publisher: Cambridge University Press
Release Date : 2013-01-24
Cognitive Impairment In Schizophrenia written by Philip D. Harvey and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-24 with Medical categories.
Although the precise mechanisms and pathways of schizophrenia remain something of a mystery, there is little dispute that cognitive deficits present as some of the clearest and most debilitating symptoms of the disease. This book describes the characteristics of cognitive deficits in schizophrenia, functional implications, the course of impairments, the genetic and biological contributions and reviews management options, including neuropsychological, psychological and pharmacological techniques. Chapters are written by leading experts in the field, in an accessible and highly informative style, ensuring the content is clinically relevant. State-of-the-art information about new developments in the treatment of related features of the illness, such as disability, is provided. The wide ranging focus of this volume will appeal to clinicians and academic researchers working with patients impaired by severe mental illness.
Handbook Of Computational Social Science Volume 1
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Author : Uwe Engel
language : en
Publisher: Routledge
Release Date : 2021-11-10
Handbook Of Computational Social Science Volume 1 written by Uwe Engel and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-10 with Computers categories.
The Handbook of Computational Social Science is a comprehensive reference source for scholars across multiple disciplines. It outlines key debates in the field, showcasing novel statistical modeling and machine learning methods, and draws from specific case studies to demonstrate the opportunities and challenges in CSS approaches. The Handbook is divided into two volumes written by outstanding, internationally renowned scholars in the field. This first volume focuses on the scope of computational social science, ethics, and case studies. It covers a range of key issues, including open science, formal modeling, and the social and behavioral sciences. This volume explores major debates, introduces digital trace data, reviews the changing survey landscape, and presents novel examples of computational social science research on sensing social interaction, social robots, bots, sentiment, manipulation, and extremism in social media. The volume not only makes major contributions to the consolidation of this growing research field but also encourages growth in new directions. With its broad coverage of perspectives (theoretical, methodological, computational), international scope, and interdisciplinary approach, this important resource is integral reading for advanced undergraduates, postgraduates, and researchers engaging with computational methods across the social sciences, as well as those within the scientifi c and engineering sectors.
Genomic And Personalized Medicine
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Author : Geoffrey S. Ginsburg
language : en
Publisher: Academic Press
Release Date : 2012-11-29
Genomic And Personalized Medicine written by Geoffrey S. Ginsburg and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-29 with Science categories.
Genomic and Personalized Medicine, Second Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Medicine - is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis
Neuroimaging Genetics
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Author : Kristin L. Bigos
language : en
Publisher: Oxford University Press
Release Date : 2016
Neuroimaging Genetics written by Kristin L. Bigos and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Medical categories.
Neuroimaging Genetics: Principles and Practices is the comprehensive volume edited by Drs. Bigos, Hariri, and Weinberger and co-authored by the preeminent scholars in the field. This text reviews the basic principles of neuroimaging techniques and their application to neuroimaging genetics. The work presented in this volume elaborates on the explosive interest from diverse research areas in psychiatry and neurology in the use of imaging genetics as a unique tool to establish and identify mechanisms of risk, establish biological significance, and extend statistical evidence of genetic associations.
Innovative Applications With Artificial Intelligence Methods In Neuroimaging Data Analysis
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Author : Yao Wu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-02-08
Innovative Applications With Artificial Intelligence Methods In Neuroimaging Data Analysis written by Yao Wu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-08 with Science categories.
Networks In Movement Disorders
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Author : Alberto Albanese
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-30
Networks In Movement Disorders written by Alberto Albanese and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-30 with Medical categories.