Killer T
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Killer T
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Author : Robert Muchamore
language : en
Publisher: Bonnier Publishing Fiction Ltd.
Release Date : 2018-09-06
Killer T written by Robert Muchamore and has been published by Bonnier Publishing Fiction Ltd. this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-06 with Juvenile Fiction categories.
Terrifying. Romantic. Huge in scope. A story for our times. Harry and Charlie are teenagers whose lives are shaped by a society that's shifting around them. He is a lonely Brit in his first term at a Las Vegas high school. She is an unlikely friend, who gets accused of mixing a batch of explosives that blew up a football player. The two of them are drawn together at a time when gene editing technology is starting to explode. With a lab in the garage anyone can beat cancer, enhance their brain to pass exams, or tweak a few genes for that year-round tan and perfect beach body. But in the wrong hands, cheap gene editing is the most deadly weapon in history. Killer T is a synthetic virus with a ninety per-cent mortality rate, and the terrorists who created it want a billion dollars before they'll release a vaccine. Fast-paced, compelling and frighteningly close to reality, this is the first standalone novel from the internationally bestselling author of CHERUB.
Killer T
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Author : Robert Muchamore
language : en
Publisher:
Release Date : 2019-06-03
Killer T written by Robert Muchamore and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-03 with categories.
Our world is about to change in ways we can barely imagine. Killer T is a novel about growing up in that world.
Cancer Through The Lens Of Evolution And Ecology
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Author : Jason A. Somarelli
language : en
Publisher: CRC Press
Release Date : 2024-05-29
Cancer Through The Lens Of Evolution And Ecology written by Jason A. Somarelli and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-29 with Medical categories.
Cancer cells exist in an ever-changing “ecology” and are subject to evolutionary pressures just like any species in nature. This edited book explores the following themes: 1) how the dynamics of mutation, epigenetics, and gene expression noise are sources of genetic diversity; 2) how scarce resources influence cancer therapy resistance; 3) how predator-prey dynamics are mirrored in immune-cancer cross-talk; 4) how cancer cells parallel niche construction theory; 5) how changing fitness landscapes enable cancer growth; and 6) how cancer cells interact within the body. The book is a resource for understanding cancer as a disease of multicellularity grounded in evolutionary principles. By using this knowledge, researchers are starting to exploit these behaviors for treatment paradigms. Key Features Bridges disciplines exemplifying the ways disparate fields create new perspectives when integrated. Offers insights from leading scholars in cancer biology, ecology and evolutionary biology. Provides a timely recognition by oncologists that evolutionary paradigms are crucial for breakthroughs in cancer treatment. Integrates basic and applied sciences of oncology and evolutionary biology.
Cd1 And Mr1 Restricted T Cells In Antimicrobial Immunity
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Author : S.M. Mansour Haeryfar
language : en
Publisher: Frontiers Media SA
Release Date : 2016-01-21
Cd1 And Mr1 Restricted T Cells In Antimicrobial Immunity written by S.M. Mansour Haeryfar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-21 with Cytology categories.
Cell-mediated immunity to extracellular and intracellular microbes has been traditionally linked to CD4+ and CD8+ T cells that recognize pathogen-derived peptides in the context of major histocompatibility complex (MHC) class II and class I molecules, respectively. Recent progress in our understanding of early host defense mechanisms has brought ‘unconventional’, innate-like T cells into the spotlight. These are a heterogeneous population of non-MHC-restricted T cells that exhibit ‘memory-like’ properties and mount emergency responses to infection. They may directly detect and destroy infected cells, but are best known for their ability to regulate downstream effector cells including but not limited to conventional T cells. Innate-like T cells include among others CD1-restricted natural killer T (NKT) cells and MR1-restricted mucosa-associated invariant T (MAIT) cells. NKT cells recognize lipid antigens, and MAIT cells were recently demonstrated to respond to microbe-derived vitamin B metabolites. However, much remains to be learned about the antigen specificity range of these cells, their activation mode and their true potentials in immunotherapeutic applications. Like in many other areas of biology, uncertainties and controversies surrounding these cells and some of the experimental models, techniques and reagents employed to study them have brought about excitement and sometimes hot debates. This Special Topic was launched to provide updated reviews on protective and/or pathogenic roles of NKT and MAIT cells during infection. Leading experts discuss current controversies, pressing questions and the challenges that lie ahead for the advancement of this intriguing and rapidly evolving area of immunology. Unlike MHC, CD1 and MR1 display very limited polymorphism. Therefore, NKT and MAIT cells may be considered attractive targets for various diseases in diverse human populations. The potential benefits of NKT cell- and MAIT cell-based vaccination and treatment strategies in infectious diseases is an important subject that is also covered in this Topic.
Nots
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Author : Mark C. Taylor
language : en
Publisher: University of Chicago Press
Release Date : 1993-08-15
Nots written by Mark C. Taylor and has been published by University of Chicago Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-08-15 with Philosophy categories.
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Role Of Cd1 And Mr1 Restricted T Cells In Immunity And Disease
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Author : Kazuya Iwabuchi
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-18
Role Of Cd1 And Mr1 Restricted T Cells In Immunity And Disease written by Kazuya Iwabuchi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-18 with categories.
CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which includes Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells. Like iNKT cells, MR1-restricted T cells express semi-invariant TCRs and display innate-like functions. MR1-restricted T cells, also called mucosal-associated invariant T (MAIT) cells, have been implicated in immune responses against a variety of pathogens such as Mycobacterium tuberculosis, Pseudomonas aeruginosa, Helicobacter pylori, hepatitis C virus and influenza virus. Moreover, these cells contribute to autoimmune and inflammatory diseases, including colitis, rheumatoid arthritis, psoriasis, lupus, and diabetes.
Essentials Of Medical Physiology
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Author : K Sembulingam
language : en
Publisher: Jaypee Brothers Medical Publishers
Release Date : 2019-08-31
Essentials Of Medical Physiology written by K Sembulingam and has been published by Jaypee Brothers Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-31 with Medical categories.
Quick Look Nursing Pathophysiology
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Author : Bernadette Madara
language : en
Publisher: Jones & Bartlett Publishers
Release Date : 2007-09-25
Quick Look Nursing Pathophysiology written by Bernadette Madara and has been published by Jones & Bartlett Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-25 with Medical categories.
Quick Look Nursing: Pathophysiology, Second Edition is designed to assist nursing students and practicing nurses with basic pathophysiology of common adult health problems likely to be encountered in either the inpatient or outpatient setting. Organized by a body system approach, each section begins with a brief review of anatomy and physiology and includes a listing of diagnostic measures pertinent to that system.
Comprehensive Toxicology
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Author :
language : en
Publisher: Elsevier
Release Date : 2017-12-01
Comprehensive Toxicology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-01 with Science categories.
Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts
Remington And Klein S Infectious Diseases Of The Fetus And Newborn Infant
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Author : Christopher B. Wilson
language : en
Publisher: Elsevier Health Sciences
Release Date : 2015-03-16
Remington And Klein S Infectious Diseases Of The Fetus And Newborn Infant written by Christopher B. Wilson and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-16 with Medical categories.
Infectious Diseases of the Fetus and Newborn Infant, written and edited by Drs. Remington, Klein, Wilson, Nizet, and Maldonado, remains the definitive source of information in this field. The 8th edition of this authoritative reference provides the most up-to-date and complete guidance on infections found in utero, during delivery, and in the neonatal period in both premature and term infants. Special attention is given to the prevention and treatment of these diseases found in developing countries as well as the latest findings about new antimicrobial agents, gram-negative infections and their management, and recommendations for immunization of the fetus/mother. Nationally and internationally recognized in immunology and infectious diseases, new associate editors Nizet and Maldonado bring new insight and fresh perspective to the book. Form a definitive diagnosis and create the best treatment plans possible using evidence-based recommendations and expert guidance from world authorities. Locate key content easily and identify clinical conditions quickly thanks to a consistent, highly user-friendly format now featuring a full-color design with hundreds of illustrations, and fresh perspectives from six new authoritative chapter lead authors. Explore what's changing in key areas such as: - emerging problems and concepts in maternal, fetal, and neonatal infectious diseases - anticipation and recognition of infections occurring in utero, during delivery, and in the neonatal period Stay on the cutting edge of your field with new and improved chapters including: obstetric factors associated with infections of the fetus and newborn infant; human milk; borella infections; tuberculosis; bordetella pertussis and other bordetella sp infections; herpes simplex; toxoplasmosis; pneumocystis and other less common fungal infections; and healthcare-associated infections in the nursery Keep up with the most relevant topics in fetal/neonatal infectious disease including new antimicrobial agents, gram- negative infections and their management, and recommendations for immunization of the fetus/mother. Overcome clinical challenges in developing countries where access to proper medical care is limited. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices. Identify and treat infections with the latest evidence-based information on fighting life-threatening diseases in the fetus and newborn infants.