Kras
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Kras
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Author : Andrew G. Stephen
language : en
Publisher: Springer Nature
Release Date : 2024
Kras written by Andrew G. Stephen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024 with Cancer categories.
"This volume details protocols ranging from high yield production metabolically labeled KRAS for NMR studies to approaches that quantify engagement of novel molecules that bind KRAS in live cells. Chapters focus on protein production and characterization, biochemical assays, cell-based assays, KRAS-membrane interactions, targeting KRAS, and cell models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, KRAS: Methods and Protocols aims to provide methods that will be instrumental in the development of future clinically approved KRAS therapeutics"--Back cover.
Fast Facts For Patients Colorectal Cancer With Kras Mutation
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Author : Rona Yaeger
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2024-03-25
Fast Facts For Patients Colorectal Cancer With Kras Mutation written by Rona Yaeger and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-25 with Medical categories.
Colorectal cancer (CRC) is cancer that begins in the colon or rectum of the digestive system. KRAS is a protein that sends signals to cells telling them to divide. In healthy cells, KRAS can be switched on and off. In some cancer cells, gene mutations cause changes in the KRAS protein that mean it is constantly switched on, driving cells to divide. KRAS mutation status can be used to guide treatment decisions. New treatments that target a KRAS mutation have been approved for non-small cell lung cancer and are now being tested for CRC. Other treatments are also being developed.
Fast Facts For Patients Non Small Cell Lung Cancer With Kras Mutation
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Author : A.-M. Baird
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2023-03-09
Fast Facts For Patients Non Small Cell Lung Cancer With Kras Mutation written by A.-M. Baird and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-09 with Medical categories.
Non-small cell lung cancer (NSCLC) is one of two main types of lung cancer. Some lung cancers spread to other parts of the body before they are diagnosed. A cancer that has spread is called ‘metastatic’. New lung cancer treatments are being developed that directly target the gene mutations that control how cancers grow and spread. The most important gene mutations in cancer are called ‘driver mutations’. In NSCLC, this includes KRAS mutations, which can be used as targets for treatment. There are new treatments designed for lung cancers with a KRAS mutation that are already available. And more are being developed. Treatments in development are tested in clinical trials. There are several different phases of clinical trials that people with cancer can take part in. This booklet aims to help patients with NSCLC understand their options so that they can talk to their doctors, nurses, and medical team about their cancer and its treatment. Table of Contents: • What is non-small cell lung cancer? • How can lung cancer develop? • What is metastatic NSCLC? • More about genes and cancer • Oncogenes and cancer • Driver mutations and biomarkers • How your doctor knows your cancer is KRAS-positive • More about KRAS • What does having a KRAS-positive cancer mean for me? • Talking to your doctor about your treatment • About clinical trials and research • Finding further information and support
Fast Facts For Patients Non Small Cell Lung Cancer With Kras Mutation
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Author : Anne-Marie Baird
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2023-03-31
Fast Facts For Patients Non Small Cell Lung Cancer With Kras Mutation written by Anne-Marie Baird and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-31 with Medical categories.
Non-small cell lung cancer (NSCLC) is one of two main types of lung cancer. Some lung cancers spread to other parts of the body before they are diagnosed. A cancer that has spread is called ‘metastatic’. New lung cancer treatments are being developed that directly target the gene mutations that control how cancers grow and spread. The most important gene mutations in cancer are called ‘driver mutations’. In NSCLC, this includes KRAS mutations, which can be used as targets for treatment. There are new treatments designed for lung cancers with a KRAS mutation that are already available. And more are being developed. Treatments in development are tested in clinical trials. There are several different phases of clinical trials that people with cancer can take part in. This booklet aims to help patients with NSCLC understand their options so that they can talk to their doctors, nurses, and medical team about their cancer and its treatment. Table of Contents: • What is non-small cell lung cancer? • How can lung cancer develop? • What is metastatic NSCLC? • More about genes and cancer • Oncogenes and cancer • Driver mutations and biomarkers • How your doctor knows your cancer is KRAS-positive • More about KRAS • What does having a KRAS-positive cancer mean for me? • Talking to your doctor about your treatment • About clinical trials and research • Finding further information and support
A Rational Two Step Approach To Kras Mutation Testing In Colorectal Cancer Using High Resolution Melting Analysis And Pyrosequencing
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Author : Cherkessk Cherkessk Press
language : en
Publisher:
Release Date : 2017-01-03
A Rational Two Step Approach To Kras Mutation Testing In Colorectal Cancer Using High Resolution Melting Analysis And Pyrosequencing written by Cherkessk Cherkessk Press and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-03 with categories.
KRAS mutation testing is mandatory in the management of metastatic colorectal cancer prior to treatment with anti-EGFR antibodies as patients whose tumors express mutant KRAS do not benefit from these agents. Although the U.S. Food and Drug Administration has recently approved two in-vitro diagnostics kits for determination of KRAS status, there is generally no consensus on the preferred method and new tests are continuously being developed. Most of these techniques focus on the hotspot mutations at codons 12 and 13 of the KRAS gene. Proceeds from the sale of this book go to support an elderly disabled person.
Kras
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Author : Andrej Kranjc
language : en
Publisher: Založba ZRC
Release Date : 1997-01-01
Kras written by Andrej Kranjc and has been published by Založba ZRC this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-01-01 with Karst categories.
Prva monografija moderne dobe o »klasičnem« slovenskem krasu, o pokrajini kras. Knjigo je napisala skupina slovenskih strokovnjakov, ki se vsak v okviru svoje stroke ukvarjajo s Krasom. Besedilo v angleškem jeziku je pisano strokovno, vendar tudi dovolj poljudno, tako da je razumljivo vsakomur. V knjigi so poudarjene naravoslovne značilnosti, predvsem tiste, ki so za kras bistvenega pomena – kamen in voda – (to je geološke, hidrološke, morfološke in speleološke značilnosti) in povezanost človeka s krasom (etnologija, tradicionalna arhitektura). Delo je ilustrirano z več kot 200 ilustracijami, kartami, preglednicami, grafikoni in skicami.
High Resolution Melting Analysis For Rapid And Sensitive Egfr And Kras Mutation Detection In Formalin Fixed Paraffin Embedded Biopsies
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Author : Applied Research Applied Research Press
language : en
Publisher:
Release Date : 2015-09-14
High Resolution Melting Analysis For Rapid And Sensitive Egfr And Kras Mutation Detection In Formalin Fixed Paraffin Embedded Biopsies written by Applied Research Applied Research Press and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-14 with categories.
Epithelial growth factor receptor (EGFR) and KRAS mutation status have been reported as predictive markers of tumour response to EGFR inhibitors. High resolution melting (HRM) analysis is an attractive screening method for the detection of both known and unknown mutations as it is rapid to set up and inexpensive to operate. However, up to now it has not been fully validated for clinical samples when formalin-fixed paraffin-embedded (FFPE) sections are the only material available for analysis as is often the case. This is the first extensive validation of HRM on FFPE samples using the detection of EGFR exons 18 to 21 mutations and KRAS exon 2 mutations. Our results demonstrate the utility of HRM analysis for the detection of somatic EGFR and KRAS mutations in clinical samples and for screening of samples prior to sequencing. We estimate that by using HRM as a screening method, the number of sequencing reactions needed for EGFR and KRAS mutation detection can be reduced by up to 80% and thus result in substantial time and cost savings.
Oncogenic Ras Dependent Reprogramming Of Cellular Plasticity
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Author : Alessandro Rimessi
language : en
Publisher: Frontiers Media SA
Release Date : 2020-06-15
Oncogenic Ras Dependent Reprogramming Of Cellular Plasticity written by Alessandro Rimessi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-15 with categories.
Kras
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Author : Marcus Lauesen
language : da
Publisher: Lindhardt og Ringhof
Release Date : 2017-07-15
Kras written by Marcus Lauesen and has been published by Lindhardt og Ringhof this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-15 with Fiction categories.
"Kras" er historien om den kradsbørstige og dog godhjertede Kras, der higer efter at blive en accepteret del af lillebyens lokalsamfund. Derfor indvilliger Kras i at stå for indsamlingen til sognerådsformandens sølvbryllup. Indsamlingen går godt, men Kras opnår alligevel ikke den anerkendelse, han havde håbet på. Til gengæld får han en gave fra en uventet side. En gave, han aldrig havde turde drømme om ... Marcus Lauesen (1907-75) var en dansk forfatter og digter. Marcus Lauesen voksede op på Aabenraa-egnen i Sønderjylland inden genforeningen. Den sønderjyske identitet er et genkommende tema i Marcus Lauesens forfatterskab.
Therapeutic Targeting Of Ras Mutant Cancers
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Author : Edward C. Stites
language : en
Publisher: Cambridge University Press
Release Date : 2022-09-15
Therapeutic Targeting Of Ras Mutant Cancers written by Edward C. Stites and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-15 with Medical categories.
The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.