Laron Syndrome From Man To Mouse
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Laron Syndrome From Man To Mouse
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Author :
language : en
Publisher:
Release Date : 2011
Laron Syndrome From Man To Mouse written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with HEALTH & FITNESS categories.
Laron Syndrome From Man To Mouse
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Author : Zvi Laron
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-11-25
Laron Syndrome From Man To Mouse written by Zvi Laron and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-25 with Medical categories.
Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.
Textbook Of Energy Balance Neuropeptide Hormones And Neuroendocrine Function
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Author : Eduardo A. Nillni
language : en
Publisher: Springer
Release Date : 2018-07-20
Textbook Of Energy Balance Neuropeptide Hormones And Neuroendocrine Function written by Eduardo A. Nillni and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-20 with Medical categories.
This textbook presents for the first time a comprehensive body of the latest knowledge in the field of neuropeptides and their action on energy balance. It contains a detailed and comprehensive account of the specific hypothalamic peptides in regards to their roles in energy balance, food intake control and co-morbidities, to better understand the patho-physiology of obesity. The textbook includes an examination the history of the evolution of human society from a thin to the obese phenotype and, within that context, how modern society habits and industrial food production did not respect the evolutionary trait resulting in changes in the energy balance set point. It provides a novel conceptualization of the problem of obesity when considering the biochemistry of peptide hormones and entertaining novel ideas on multiple approaches to the problems of energy balance, as well as demonstrates and explains why alterations in pro-hormone processing are paramount to understand metabolic disease. This text is excellent material for teaching graduate and medical school courses, as well as a valuable resource for researchers in biochemistry, cell, and molecular biology, neuroscientists, physician endocrinologists, and nutritionists.
Murine Models Energy Balance And Cancer
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Author : Nathan A. Berger
language : en
Publisher: Springer
Release Date : 2015-06-19
Murine Models Energy Balance And Cancer written by Nathan A. Berger and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-19 with Medical categories.
This volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer control and treatment. The worldwide obesity pandemic has been extensively studied by epidemiologic and observational studies and even, in some cases, by randomized controlled trials. However, the development and control of obesity, its comorbidities and its impact on cancer usually occurs over such long periods that it is difficult, if not impossible to conduct randomized controlled trials in humans to investigate environmental contributions to obesity, energy balance and their impact on cancer. In contrast, model organisms, especially mice and rats, provide valuable assets for performing these studies under rigorously controlled conditions and in sufficient numbers to provide statistically significant results. In this volume, many of the leading and new murine models used to study the mechanisms and mediators linking cancer with obesity, sleep, exercise, their modification by environment and how they may continue to be used to further elucidate these relations as well as to explore preclinical aspects of prevention and/or therapeutic intervention are considered. This volume provides an important compilation and analysis of major experimental systems and principles for further preclinical research with translational impact on energy balance and cancer.
Growth Hormone Resistance
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Author : Martin O. Savage
language : en
Publisher:
Release Date : 1996
Growth Hormone Resistance written by Martin O. Savage and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Insulin-like growth factor-binding proteins categories.
Examining growth hormone resistance, this text includes coverage of such topics as: growth hormone receptor signalling; metabolic actions of growth hormone - direct and indirect; and IGF bioactivity and its modification in growth hormone resistance in childhood.
Encyclopedia Of Biomedical Gerontology
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-11-20
Encyclopedia Of Biomedical Gerontology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-20 with Medical categories.
Encyclopedia of Biomedical Gerontology, Three Volume Set presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention. Provides a ‘one-stop’ resource to information written by world-leading scholars in the field of biomedical gerontology Fills a critical gap of information in a field that has seen significant progress in the last 10 years
The Growth Hormone Insulin Like Growth Factor Axis During Development
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Author : Isabel Varela-Nieto
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-12-17
The Growth Hormone Insulin Like Growth Factor Axis During Development written by Isabel Varela-Nieto and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-17 with Medical categories.
Insulin-like growth factor (IGF)-I is a widely expressed growth factor with diverse effects on many tissues throughout development and in adult life. The purpose of this work is to provide detailed and updated information on the role of the growth hormone (GH)-IGF axis in fetal and postnatal development, as well as its physiological functions and implications in pathology.
Lessons From Laron Syndrome Ls 1966 1992
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Author : Zvi Laron
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1993-01-01
Lessons From Laron Syndrome Ls 1966 1992 written by Zvi Laron and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-01-01 with Medical categories.
Laron Syndrome (LS) is a disease characterized by resistance to growth hormone (GH) and caused by molecular defects of the GH receptor, leading to a deficiency of insulin-like growth factor-1 (IGF-1) and a significant impairment of growth. The syndrome is a unique human model of a peptide hormone receptor defect and GH-IGF-1 interaction. It offers the opportunity to study the consequences of long-term IGF-1 deficiency and the role of IGF-1 in growth and metabolism. With the recent biosynthesis of IGF-1 and the initiation of IGF-1 therapy, a whole new world of basic biological interactions is opening up. This volume brings together leading researchers in genetics, endocrinology, pediatrics, biochemistry, physiology and pharmacology to summarize what is now known about LS, and to discuss the lessons learned from studying and treating this disease since its initial description in 1966. Special features include the demography of LS, and the first data on the long-term IGF-1 treatment of a large group of patients.
Stem Cells
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Author : Mariusz Z. Ratajczak
language : en
Publisher: Springer Nature
Release Date : 2020-01-02
Stem Cells written by Mariusz Z. Ratajczak and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-02 with Science categories.
Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field.
Mendelian Inheritance In Man
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Author : Victor Almon McKusick
language : en
Publisher:
Release Date : 1992
Mendelian Inheritance In Man written by Victor Almon McKusick and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Genetic disorders categories.