Lectins And Cancer
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Lectins And Cancer
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Author : Hans-Joachim Gabius
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Lectins And Cancer written by Hans-Joachim Gabius and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Molecular recognition undoubtedly governs any aspect of cellular interaction. To understand tumor cell growth regulation and spread, analysisof protein carbohydrate interactions can contribute to lead to the establishment of rational methods for diagnosis and therapy. Chemically and biochemically optimized preparation of adequate tools, their application for localization of receptor (tissue lectin) and ligand (cellular glycoconjugate) pairs in tumor cells and tumor sections and the usefulness of a lectin from a plant extract as potent immunomodulator indicate the prospect for a place of such techniques in pathology and oncology.
Lectins And Cancer
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Author : Hans-Joachim Gabius
language : en
Publisher: Springer Verlag
Release Date : 1991
Lectins And Cancer written by Hans-Joachim Gabius and has been published by Springer Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
Lectins And Glycoconjugates In Oncology
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Author : Hans-Joachim Gabius
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Lectins And Glycoconjugates In Oncology written by Hans-Joachim Gabius and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Cellular glycoconjugates and their specific receptors, e.g. lectins, form a recognitive and informative transfer system that justifies special scientific and clinical attention. In various contributions reviewing the initiation and recent progress in this rapidly developing field advances in clinical oncology are discussed with regard to basic sciences as well as their application in clinical sciences. The approaches comprise reports from diverse fields such as biochemistry, cell biology, pathology and clinical oncology, addressing questions of how tumors grow and spread, and leading to the improvement of clinical management and tumor diagnosis.
Development Of Lectins For Cancer Specific Fucosylation
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Author : Harmin Herrera
language : en
Publisher:
Release Date : 2019
Development Of Lectins For Cancer Specific Fucosylation written by Harmin Herrera and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Biochemical markers categories.
Changes in serum glycosylation have long been associated with hepatocellular carcinoma (HCC), and these modifications are often detected with sugar-binding proteins called lectins. HCC is associated with increased serum fucosylation, and this sugar is often detected with the Aleuria aurantia lectin (AAL). However, this lectin binds fucose in several forms, one of which is associated with cancer ([alpha]1-6 linked fucosylation) and some of which are not. Thus, its use in clinical and tissue analysis is limited. We have created a recombinant AAL, which contains a single amino acid mutation: N224Q (rAALN224Q), within the binding site 5, and this lectin has increased sensitivity to the cancer-specific fucosylated glycan. Our analysis of rAALN224Q has shown that the mutation within one specific fucose binding pocket had a major impact upon the mutated site as well as on sites that were not mutated and led to a lectin with altered binding specificities. This lectin is currently part of a diagnostic test under evaluation for the early detection of HCC. We have further explored the changes in N-linked glycosylation associated directly with HCC tissue through a method of N-linked glycan matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS). MALDI IMS of N-linked glycan revealed inter- and intra-tumor heterogeneity shown by expression and spatial localization of glycans in the tumor. Tumors were associated with alterations in mannosylation, fucosylation, branching, and complex glycan formation. Importantly, all tumors were associated with some change in glycosylation, but there was significant glycan heterogeneity.
Lectins And Pathology
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Author : Michel Caron
language : en
Publisher: CRC Press
Release Date : 2003-09-02
Lectins And Pathology written by Michel Caron and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-02 with Medical categories.
The present understanding of the various implications of lectins in pathology are summarised in this timely text. With contributions from leading investigators in the field of lectin research, Lectins and Pathology provides up-to-date information on key developments within this field, including the use of lectins and lectin-binding molecules as tools, the involvement of endogenous (animal or human) lectins in inflammation, cancer invasion and metastasis, as well as the importance of lectins in bacteriology and parasitology. This volume contains useful knowledge for clinical investigators, cell biologists, biochemists and biotechnologists, as well as for the graduate students interested in getting a comprehensive coverage of this field.
Lectins
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Author : Preetham Elumalai
language : en
Publisher: Springer Nature
Release Date : 2022-03-09
Lectins written by Preetham Elumalai and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-09 with Science categories.
This book reviews the relationship between receptors, carbohydrate moieties, and pathogenic surfaces and lectins’ pathophysiology of immune responses and examines the mechanisms of action of the molecules for the treatment potentials. Increasing evidence has suggested that lectin-carbohydrate interactions perform important roles in various regulations of immune responses, but much remains to be learned about these crucial properties and their interplay with other molecules. In addition, a better understanding of the structural and functional properties of lectin and the activated immune response will be of critical importance for the development of new diagnostic tools and therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the various lectin types from animal and plant as well as microbial or marine lectins, and this wide range of molecular knowledge directs us to various diseases, including infectious diseases and cancer. In presenting state-of-the-art knowledge on the interactions between lectin and its interactions,the book will help to pave the way for the development of novel targets for the prevention and treatment of many disorders.
Lectin Blocking
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Author : J. Beuth
language : en
Publisher: Lubrecht & Cramer, Limited
Release Date : 1994
Lectin Blocking written by J. Beuth and has been published by Lubrecht & Cramer, Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.
Analysis Of Lectin Binding And Lectin Effects On Human Colon Cancer And Non Cancer Cell Lines
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Author : Karineh Petrossian
language : en
Publisher:
Release Date : 2007
Analysis Of Lectin Binding And Lectin Effects On Human Colon Cancer And Non Cancer Cell Lines written by Karineh Petrossian and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Cancer cells categories.
Lectins
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Author : Arpad Pusztai
language : en
Publisher: CRC Press
Release Date : 2005-08-02
Lectins written by Arpad Pusztai and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-08-02 with Medical categories.
Lectins form a ubiquitous and important class of natural carbohydrate- binding information proteins. Although the main scientific interest was originally focussed on toxic lectins such as ricin, recent emphasis has shifted to exploring their involvement in cell-to-cell communication and recognition in microorganisms, plants and animals.; As knowledge of the basic properties and biological activities of lectins has increased, exciting opportunities have arisen for the exploitation of some of the advantageous aspects of fundamental lectinology.; "Lectins: Biomedical Perspectives" records the major achievements of an initiative, funded by the European Community, to coordinate lectin research throughout Europe.
Plants That Fight Cancer Second Edition
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Author : Spyridon E. Kintzios
language : en
Publisher: CRC Press
Release Date : 2019-06-26
Plants That Fight Cancer Second Edition written by Spyridon E. Kintzios and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-26 with Science categories.
An increasing amount of cancer research is being directed towards the investigation of plant-derived anticancer compounds, many of which have been used in traditional herbal treatments for centuries. Plants that Fight Cancer is an up-to-date, extensive review of plant genera and species with documented anti-tumor and anti-leukaemic properties. Following an overview of the disease and the diverse methods of therapy and clinical testing, the book provides a detailed examination of the plants whose compounds are currently used in conventional cancer treatment, the species which show the greatest potential as future candidates, and other species with established anticancer properties. The third section explores each of more than 150 terrestrial plant genera and species, with a review of their traditional uses, mythology, botany, active ingredients, and product applications, along with photographs and illustrations and an analysis of expected results and risks. The text closes with a discussion of algal extracts and isolated metabolites with anticancer activity, a summary of published research for each species, and chemical structures of the most important compounds.