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Leptin And The Neuroendocrine Regulation Of Body Weight And Reproduction


Leptin And The Neuroendocrine Regulation Of Body Weight And Reproduction
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Leptin And The Neuroendocrine Regulation Of Body Weight And Reproduction


Leptin And The Neuroendocrine Regulation Of Body Weight And Reproduction
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Author : Jody Dushay
language : en
Publisher:
Release Date : 2000

Leptin And The Neuroendocrine Regulation Of Body Weight And Reproduction written by Jody Dushay and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Leptin categories.




The Neuroendocrine Regulation Of Body Weight During Psuedopregnancy In The Rat


The Neuroendocrine Regulation Of Body Weight During Psuedopregnancy In The Rat
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Author : Rachael Anne Augustine
language : en
Publisher:
Release Date : 2010

The Neuroendocrine Regulation Of Body Weight During Psuedopregnancy In The Rat written by Rachael Anne Augustine and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Lactation categories.




Leptin


Leptin
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Author : V. Daniel Castracane
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-12-22

Leptin written by V. Daniel Castracane and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-22 with Medical categories.


This book is an edited collection of the literature on leptin beginning with the discovery of leptin and a study of its affect on animals and in humans. Chapters will focus on the discovery, history, roles and regulation of leptin in all the major areas of physiology, as well as on assay methods, phylogeny and genetics. The timing of this volume is long overdue and is the first comprehensive coverage of leptin physiology in the field.



Clinical Neuroendocrinology


Clinical Neuroendocrinology
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Author : Michael Wilkinson
language : en
Publisher: Cambridge University Press
Release Date : 2019-01-03

Clinical Neuroendocrinology written by Michael Wilkinson and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-03 with Medical categories.


A concise and innovative account of clinical neuroendocrine disorders and the key principles underlying their diagnosis and management.



Leptin And Reproduction


Leptin And Reproduction
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Author : Michael C. Henson
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Leptin And Reproduction written by Michael C. Henson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.


The isolation of leptin in 1994 and its characterization as a factor influencing appetite, energy balance, and adiposity, immediately thrust the polypeptide into the rapidly growing body of literature centered on the physiology of obesity. The growing clinical awareness of obesity as a major health risk in developed societies dovetailed perfectly with any of a number of roles that leptin might play in this abenant physiological condition. Almost unnoticed amidst the excitement generated by early leptin publications was the suggestion that the "fat hormone" might also regulate a wide range of systems and events important to reproduction, including pubertal development, gonadal endocrinology, fettility, and pregnancy. Recognizing this potential, a relatively small cadre of researchers began to examine leptin specifically as a reproductive hormone, thus creating a new and fertile field of investigation. Interest in this area has since gained momentum and an increased number of participants have now made significant contributions to our understanding of many leptin-related mechanisms that are relevant to reproductive biology. Leptin and Reproduction is the first major volume to specifically address leptin as a reproductive hormone and closely examines the advances made in the short time since this field of interest developed. Preeminent researchers ti'om many of the subdisciplines working within this area present a welcomed compendium of the wealth of related literature and voice novel interpretations of cun'ent advances.



Neuroendocrinology Of Leptin


Neuroendocrinology Of Leptin
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Author : Ehud Ur
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2000

Neuroendocrinology Of Leptin written by Ehud Ur and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.


The discovery of the adipostatic hormone leptin has transformed our understanding of the neurobiology of appetite control and has helped to establish the biological basis of obesity. In recent years there has been a wealth of publications relating to the physiology of this peptide. This volume sets out to draw together key features of the central effects of leptin. Contributions from leading authorities in the field include reviews of leptin's actions on hypothalamic peptides, the role of leptin in fasting, its effects on reproductive function, and evidence supporting endogenous brain production of the peptide. Endocrinologists, diabetologists, obesity specialists and Neurobiologists will be interested in this succint and timely review of the effects of the adipostatic hormone leptin on neuroendocrine function.



Brain Somatic Cross Talk And The Central Control Of Metabolism


Brain Somatic Cross Talk And The Central Control Of Metabolism
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Author : Claude Kordon
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Brain Somatic Cross Talk And The Central Control Of Metabolism written by Claude Kordon and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.


In mammals, a robust physiologic system acts to maintain relative constancy of weight. A key element of this system is leptin. The nature of this "brain-somatic" cross talk is as yet poorly understood, but it is likely to have important implications for the pathophysiology and treatment of obesity, diabetes and other metabolic disorders.



Leptin And Neuropeptide Y As A Link Between Body Fat Fertility And Appetite In Ruminants


Leptin And Neuropeptide Y As A Link Between Body Fat Fertility And Appetite In Ruminants
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Author : Christopher David Morrison
language : en
Publisher:
Release Date : 2001

Leptin And Neuropeptide Y As A Link Between Body Fat Fertility And Appetite In Ruminants written by Christopher David Morrison and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Leptin categories.


Leptin is a protein hormone that is produced by adipocytes, and serum concentrations of leptin are sensitive to changes in both body adipose mass and metabolic energy balance. Thus circulating leptin levels may be an endocrine cue linking body fat and energy status to hypothalamic pathways regulating appetite and reproduction. Working in concert with leptin is Neuropeptide Y, a hypothalamic peptide known to function in the regulation of appetite and secretion of luteinizing hormone (LH). In undernourished animals hypothalamic levels of NPY increase, and treatment with NPY stimulates food intake and decreases LH. The objective of the present set of experiments was to characterize the leptin-NPY axis in ruminants, and to determine if these pathways are associated with the perception of nutritional status and the subsequent regulation of appetite and reproduction. It was found that a continuous, linearly increasing, intracerebroventricular (icv) infusion of NPY produced a dramatic suppression in LH, and a biphasic increase in growth hormone (GH) in ovariectomized lambs. Thus, providing evidence that the increase in hypothalamic NPY that occurs in undernourished lambs is likely a significant player in the hypothalamic regulation of LH and GH secretion. Central (icv) infusion of leptin into well-fed and undernourished ewe lambs induced a marked reduction in feed intake in well-fed lambs, and stimulated secretion of GH but not LH in undernourished lambs. Additionally, while feed restriction increased hypothalamic NPY levels, infusions of leptin attenuated this increase. Thus, leptin was able to regulate aspects of feed intake and neuroendocrine function in ewe lambs, and this effect was at least partially mediated by NPY. Additionally, serum leptin may also regulate the secretion of peripheral hormones, such as insulin and cortisol. For these reasons, an intravenous infusion of leptin was utilized to the compare the responses of peripheral leptin to those already observed during central infusion of leptin. Despite a marked increase in serum leptin levels in response to intravenous infusion of leptin, no consistent change in feed intake, or serum concentrations of LH, GH, insulin, IGF-I, cortisol, or thyroxine was detected. These results contrast with the icv infusion data, and illustrate that well-fed lambs may be physiologically resistant to exogenous increases in serum leptin. From these data, we propose the existence of a functional leptin-NPY axis for the perception of nutritional status and subsequent regulation of appetite and neuroendocrine function in ruminants. (Abstract shortened by UMI.).



Polycystic Ovary Syndrome


Polycystic Ovary Syndrome
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Author : Andrea Dunaif
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-12

Polycystic Ovary Syndrome written by Andrea Dunaif and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-12 with Medical categories.


This volume includes the latest diagnostic criteria for PCOS and comprises the most up-to-date information about the genetic features and pathogenesis of PCOS. It critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. The book also discusses additional familial phenotypes of PCOS and their potential genetic basis. All four editors of this title are extremely prominent in the field of PCOS.



Appetite And Body Weight


Appetite And Body Weight
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Author : Tim Kirkham
language : en
Publisher: Elsevier
Release Date : 2011-04-28

Appetite And Body Weight written by Tim Kirkham and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Science categories.


There is now enough basic work to sketch out the principal systems at all levels of the brain, from prefrontal cortex to lower brainstem, which are orchestrated to provide control of food selection, preference and consumption. At the same time, the complex interplay between central systems and signals generated from peripheral systems include the gut, liver and fat stores, as well as the interactions with the neuroendocrine system can be described in some detail. A continuing theme throughout the book is that the functional analysis of appetite and food intake cannot be limited to a single focus, e.g. hypothalamic neuropeptides and their interactions, but must be based on a fully integrated view of the several contributing systems. Appetite and Body Weight: Integrative Systems and the Development of Anti-Obesity Drugs provides an expert guide to the neural, neurochemical, autonomic and endocrine interrelations which underpin appetite and the controls of food intake and body weight. The book covers many of the neurochemical entities that are currently under investigation, including: neuropeptides, leptin, insulin, monoamines and endogenous cannabinoids in relation to appetite and body-weight control. In addition to the neuroscience analysis, there are also chapters that provide an expert guide to some of the key psychological concepts that the researchers believe are essential in trying to understand the phenomena under investigation. The volume will also serve as an authoritative guide to the current emphasis on the development of novel, efficacious anti-obesity medication. Provides an integrative view of the many systems involved in appetite how they interact to effect food intake (i.e. the brain, endocrine, gut, liver etc.) Considers psychological aspects such as incentive, preference, liking and palatability, and sets these concepts in their behavioural, pharmacological and neural contexts Examines the development of novel anti-obesity drugs, drawing on experience of pharmacological development work, pre-clinical tests for anti-obesity efficacy, and clinical trials of candidate anti-obesity compounds