Leukocyte Recruitment Endothelial Cell Adhesion Molecules And Transcriptional Control
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Leukocyte Recruitment Endothelial Cell Adhesion Molecules And Transcriptional Control
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Author : Tucker Collins
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Leukocyte Recruitment Endothelial Cell Adhesion Molecules And Transcriptional Control written by Tucker Collins and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. Leukocyte Recruitment, Endothelial Cell Adhesion Molecules and Transcriptional Control: Insights for Drug Discovery outlines some of the cellular and molecular mechanisms of inflammation with contributions from top researchers. This volume provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment. This book will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery.
Adhesion Molecules Function And Inhibition
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Author : Klaus Ley
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-27
Adhesion Molecules Function And Inhibition written by Klaus Ley and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-27 with Medical categories.
This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.
Vascular Adhesion Molecules And Inflammation
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Author : Jeremy D. Pearson
language : en
Publisher: Birkhäuser
Release Date : 2013-03-07
Vascular Adhesion Molecules And Inflammation written by Jeremy D. Pearson and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
The book will provide an overview of the roles of vascular adhesion molecules in health and disease, with chapters on their cell biology, followed by chapters reviewing their importance in specific disease processes. Vascular adhesion molecules are vital for the physiological processes of leukocyte trafficking and also critically involved in the enhanced leukocyte emigration that is a key feature of all inflammatory and immune diseases. The book is designed to provide up-to-date, linked reviews of the subject suitable for postgraduate students entering the field or research workers from allied disciplines needing a modern overview.
Imaging And Mechanism Of Leukocyte Recruitment And Function In Inflammation And Infections
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Author : Zhichao Fan
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-05
Imaging And Mechanism Of Leukocyte Recruitment And Function In Inflammation And Infections written by Zhichao Fan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-05 with Science categories.
Adhesion Molecules In Health And Disease
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Author : Paul
language : en
Publisher: CRC Press
Release Date : 1997-05-16
Adhesion Molecules In Health And Disease written by Paul and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-05-16 with Science categories.
Provides an overview of the structure, transcription regulation and binding characteristics of cellular adhesion molecules and their ligands in the maintenance of function, immunological reactions and inflammatory processes with organ systems. The text examines the role of adhesion molecules in biological processes such as morphogenesis, blood coagulation, tumour metastasis, bone tissue remodelling and transplant rejection.
Structure Function And Regulation Of Molecules Involved In Leukocyte Adhesion
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Author : Peter E. Lipsky
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Structure Function And Regulation Of Molecules Involved In Leukocyte Adhesion written by Peter E. Lipsky and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Leukocyte adhesion molecules have been the subject of intense basic and preclinical research. Results from clinical trials obtained sofar with antibodies directed towards these surface proteins offer promise for the prevention of graft rejection and effective treatment of acute and chronic inflammatory disease. This volume presents a comprehensive review of contemporary research on the structure, function and regulation of leukocyte adhesion molecules and their ligands, from the molecular to the clinical level. The blend of basic science and clinical applications presented in Structure, Function and Regulation of Molecules Involved in Leukocyte Adhesion provides clear evidence of the biological importance of cell-cell interactions and the many potential clinical dividends afforded by understanding the molecular basis of cell adhesion. It will appeal to a broad range of readers in immunology and cell biology.
Inflammation And The Microcirculation
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Author : D. Neil Granger
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2010
Inflammation And The Microcirculation written by D. Neil Granger and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References
Leucocyte Adhesion
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Author : Klaus Ley
language : en
Publisher: Academic Press
Release Date : 2009-11-09
Leucocyte Adhesion written by Klaus Ley and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-09 with Science categories.
Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. This volume provides a review of the latest developments in leukocyte adhesion. Regulation of cell adhesion is important for immune system function. Contributions from leading experts in the field Reviews the latest developments
Leukocyte Recruitment In Inflammatory Disease
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Author : Gary Peltz
language : en
Publisher: Landes Bioscience
Release Date : 1996
Leukocyte Recruitment In Inflammatory Disease written by Gary Peltz and has been published by Landes Bioscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
Microcirculation
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Author : Ronald F. Tuma
language : en
Publisher: Academic Press
Release Date : 2011-04-28
Microcirculation written by Ronald F. Tuma and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Science categories.
This reference is a volume in the Handbook of Physiology, co-published with The American Physiological Society. Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous subdisciplines and subspecialties. This volume pulls all of the critical information into one volume. Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume
