Leukocyte Recruitment In Inflammatory Disease
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Leukocyte Recruitment In Inflammatory Disease
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Author : Gary Peltz
language : en
Publisher: Landes Bioscience
Release Date : 1996
Leukocyte Recruitment In Inflammatory Disease written by Gary Peltz and has been published by Landes Bioscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Inflammation categories.
Imaging And Mechanism Of Leukocyte Recruitment And Function In Inflammation And Infections
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Author : Zhichao Fan
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-05
Imaging And Mechanism Of Leukocyte Recruitment And Function In Inflammation And Infections written by Zhichao Fan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-05 with Science categories.
Leukocyte Recruitment Endothelial Cell Adhesion Molecules And Transcriptional Control
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Author : Tucker Collins
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Leukocyte Recruitment Endothelial Cell Adhesion Molecules And Transcriptional Control written by Tucker Collins and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. Leukocyte Recruitment, Endothelial Cell Adhesion Molecules and Transcriptional Control: Insights for Drug Discovery outlines some of the cellular and molecular mechanisms of inflammation with contributions from top researchers. This volume provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment. This book will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery.
Physiology Of Inflammation
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Author : Klaus Ley
language : en
Publisher: Springer
Release Date : 2013-05-27
Physiology Of Inflammation written by Klaus Ley and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-27 with Science categories.
This book covers the physiological processes relevant to inflammation. It centers on the recruitment of leukocytes to sites of injury and infection, their function in the tissue and the eventual resolution of inflammation.
Inflammation And The Microcirculation
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Author : D. Neil Granger
language : en
Publisher: Biota Publishing
Release Date : 2010-06-01
Inflammation And The Microcirculation written by D. Neil Granger and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-01 with Medical categories.
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation.
Adhesion Molecules Function And Inhibition
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Author : Klaus Ley
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-08-16
Adhesion Molecules Function And Inhibition written by Klaus Ley and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-16 with Medical categories.
Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.
Leukocyte Trafficking In Homeostasis And Disease
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Author : Joaquin Teixidó
language : en
Publisher: Frontiers Media SA
Release Date : 2019-12-30
Leukocyte Trafficking In Homeostasis And Disease written by Joaquin Teixidó and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-30 with categories.
Inflammation Fundamental Mechanisms
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Author : Ley Klaus
language : en
Publisher: World Scientific
Release Date : 2018-03-13
Inflammation Fundamental Mechanisms written by Ley Klaus and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-13 with Medical categories.
Inflammation is important in many diseases, yet it is hard to find current information on the pertinent cellular and molecular mechanisms of inflammation. This book is a current and authoritative review of various aspects of inflammation in mammalian organisms. Basic principles, including regulation by cytokines, lipid mediators, reactive oxygen species and leukocyte recruitment are followed by chapters on integrative aspects of inflammation, such as neutrophil extracellular traps, sepsis and granulomatous inflammation. Contents: TNF Superfamily in Inflammation (Marisol Veny, Richard Virgen-Slane and Carl F Ware) Complement as a Mediator of Inflammation (B Paul Morgan) Lipids and Inflammation (Valerie B O'Donnell, Robert C Murphy and Garret A FitzGerald) Reactive Oxygen Species (Ulla G Knaus) Leukocyte Adhesion (Klaus Ley and Zhichao Fan) Neutrophil Extracellular Traps (Tobias A Fuchs, Abdul Hakkim and Constantin F Urban) Sepsis (Jamison J Grailer, Matthew J Delano and Peter A Ward) Granulomatous Inflammation (Marc Hilhorst, Gene Hunder, Jörg Goronzy and Cornelia Weyand) Readership: Graduate students, medical doctors/ practitioners, researchers, pathologists and nutritionists in medicine and healthcare. Keywords: Cytokines;IL-1;TNF;Lipid Mediators;Bradykinin and Neuropeptides;Leukocyte Adhesion;Angiogenesis;Degranulation;Antimicrobial Peptides;Neutrophil Extracellular Traps (NETs);Pharmacologic Modulation of Inflammation;Sepsis;Complement;Oxygen Radicals;Reperfusion Injury;Resolution of Inflammation;Atherosclerosis;Granulomatous Inflammation;Inflammatory Bowel DiseaseReview: Key Features: Up-to-date resource Comprehensive review of the various facets of inflammation
Cell Migration In Inflammation And Immunity
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Author : Daniele D’Ambrosio
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Cell Migration In Inflammation And Immunity written by Daniele D’Ambrosio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Medical categories.
Chemokines and their receptors play a central role in the pathogenesis of numerous, perhaps all, acute and chronic inflammatory diseases. About 50 distinct chemokines produced by a variety cell types and tissues either c- stitutively or in response to inflammatory stimuli are involved in a plethora of biological processes. These small secreted proteins exert their exquisitely variegated functions upon binding to a family of seven-transmembrane spanning G-protein coupled receptors (GPCRs) composed of almost 20 distinct entities. The biological activities of chemokines range from the control of leukocyte trafficking in basal and inflammatory conditions to the regulation of hema- poiesis, angiogenesis, tissue architecture, and organogenesis. The basis for such diversified activities rests, on one hand, upon the ubiquitous nature of chemokine production and chemokine receptor expression. Virtually every cell type can produce chemokines and expresses a unique combination of chemokine receptors. On the other hand, chemokine receptors make use of a flexible and complex network of intracellular signaling machineries that can regulate a variety of cellular functions ranging from cell migration, growth, and differentiation to death. As knowledge of the size of chemokine and chemokine receptor families rapidly reaches completeness, much is still to be uncovered in terms of fu- tional architecture of the chemokine system. The disparity between the large number of chemokines and that smaller number of receptors is balanced by the promiscuity in ligand–receptor interactions, with multiple chemokines binding to the same receptor and several chemokines binding to more than one receptor.
Regulation Of Chemokine Receptor Interactions And Functions
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Author : Martin J. Stone (Ed.)
language : en
Publisher:
Release Date : 2018
Regulation Of Chemokine Receptor Interactions And Functions written by Martin J. Stone (Ed.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Biochemistry categories.
A hallmark of inflammation is the accumulation of leukocytes, which can serve to remove pathogens and necrotic tissue, but may also damage healthy tissue and exacerbate the inflammatory response. Our understanding of leukocyte recruitment in inflammation was revolutionized in the late 1980s by the discovery of chemokines (chemotactic cytokines), a family of small, secreted proteins that induce migration of selective subsets of leukocytes. Shortly afterwards, chemokines were found to exert their functions through the now familiar chemokine receptors, members of the G protein-coupled receptor superfamily. As their physiological and pathological functions were elucidated, chemokine receptors have become popular targets for drug development in inflammatory diseases as well as cancer metastasis and HIV infection. Extensive research has revealed that the functions of chemokines and their receptors are regulated at numerous levels, including: genetic mutations/polymorphisms; control of expression levels; ligand internalization via functional or decoy receptors; intrinsic selectivity of chemokine-receptor binding; hetero- or homo-oligomerization of chemokines or of receptors; alternative signalling pathways; interaction of chemokines with glycosaminoglycans; post-translational modifications; and binding to pathogen-derived inhibitors. This Special Issue of IJMS focused on the natural and pharmacological mechanisms by which the activities of chemokines and their receptors can be regulated.