Life In Our Phage World
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Life In Our Phage World
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Author : Forest Rohwer
language : en
Publisher:
Release Date : 2014-12-01
Life In Our Phage World written by Forest Rohwer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-01 with Bacteriophages categories.
We share the Earth with more than 10,000,000,000,000,000,000,000,000,000,000 phages. Everywhere they thrive, from well-fed guts to near-boiling acidic springs, from cryoconite holes to endolithic fissures. They travel from one microbial host to the next as virions, their genetic weapons packaged inside a protective protein shell. If you could lay all of these nanoscopic phage virions side-by-side, the line-up would stretch over 42 million light years. Through their daily shenanigans they kill or collaborate with their microbial hosts to spur microbial evolution and maintain ecosystem functioning. We have learned much about them since their discovery by Frederick Twort a century ago. They also taught us that DNA, not protein, is the hereditary material, unraveled the triplet genetic code, and offered their enzymes as indispensible tools for the molecular biology revolution. More contributions will be forthcoming since the vast majority of phages await discovery. Phage genomes harbor the world's largest cache of unexplored genetic diversity, and we now have the equipment needed to go prospecting. Although there are field guides to birds, insects, wild flowers, even Bacteria, there was no such handbook to guide the phage explorer. Forest Rohwer decided to correct this oversight, for novice and expert alike, and thus was born Life in Our Phage World. A diverse collection of 30 phages are featured. Each phage is characterized by its distinctive traits, including details about its genome, habitat, lifestyle, global range, and close relatives. The beauty of its intricate virion is captured in a pen-and-ink portrait by artist Benjamin Darby. Each phage also stars in a carefully researched action story relating how that phage encounters, exploits, kills, or otherwise manipulates its host. These behaviors are imaginatively illustrated by fine artist Leah L. Pantea. Eight researchers that work closely with phages also relate their experiences as inhabitants of the phage world. Rohwer has years of first-hand experience with the phage multitudes in ecosystems ranging from coral reefs to the human lung to arctic waters. He pioneered the key metagenomic methods now widely used to catalog and characterize Earth's microbial and viral life. Despite research advances, most people, many scientists included, remain unaware of the ongoing drama in our phage world. In anticipation of 2015, the centennial of phage discovery, Forest assembled a cadre of writers, artists, scientists, and a cartographer and set them to work. The result? This alluring field guide-a feast for the imagination and a celebration of phage diversity."
The Good Virus
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Author : Tom Ireland
language : en
Publisher: Hachette UK
Release Date : 2023-06-29
The Good Virus written by Tom Ireland and has been published by Hachette UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-29 with Science categories.
'The book that might change the world ... This is luxury-class science writing' TELEGRAPH 'A delight. To learn more about phages is to discover fascinating details about a hidden world' NATURE 'Outstanding' CLIVE MYRIE 'This thrilling book will amaze you' MATTHEW COBB __________ Not all viruses are out to get us - in fact, the viruses that do us harm are vastly outnumbered by viruses that can actually save lives. At every moment, within your body and all around you, trillions of microscopic combatants are fighting an invisible war. Countless times per second, 'good' viruses known as phages are infecting and destroying bacteria. These phages are the most abundant life form on the planet and have an incredible power to heal rather than harm. So why have most of us never even heard of them? The Good Virus reveals how personalities, power and politics have repeatedly crashed together to hinder our understanding of these weird and wonderful life forms. We explore why Stalin's Soviet Union embraced using phages to fight disease but the rest of the world shunned the idea. We find out why scientists only recently realised phages are central to all ecosystems on Earth. And we meet the often eccentric phage heroes who have shaped the strange history of this field and are unlocking its exciting future. Faced with the threat of antibiotic resistance, we need phages now more than ever. The Good Virus celebrates what phages could do for us and our planet if they are at last given the attention they deserve. __________ 'A new scientific frontier that couldn't be more fascinating or vital. This book is ahead of the curve and deserves to become a classic.' DANIEL M. DAVIS 'Incredible and though provoking. Phages are the superheroes of the human biome.' SUE BLACK
The Good Virus The Amazing Story And Forgotten Promise Of The Phage
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Author : Tom Ireland
language : en
Publisher: W. W. Norton & Company
Release Date : 2023-08-15
The Good Virus The Amazing Story And Forgotten Promise Of The Phage written by Tom Ireland and has been published by W. W. Norton & Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-15 with Science categories.
How a mysterious, super-powerful—yet long-neglected—microbe rules our world and can rescue our health in the age of antibiotic resistance. At every moment, within our bodies and all around us, trillions of microscopic combatants are waging a war that shapes our health and life on Earth. Countless times per second, viruses known as phages attack and destroy bacteria while leaving all other life forms, including us, unscathed. Vastly outnumbering the viruses that do us harm, phages power ecosystems, drive evolutionary innovation, and harbor a remarkable capacity to heal life-threatening infections when conventional antibiotics fail. Yet most of us have never heard of them, thinking of viruses only as enemies to be feared. The Good Virus prompts us to reconsider, and to discover, how these viruses could save countless lives if we can learn to harness their extraordinary abilities. Taking us inside the ongoing quest to use phages’ powers for good, Tom Ireland introduces us to the brilliant, often eccentric, scientists who have fought to realize phages’ potential in the face of doubt and political intrigue. We meet the renegade French-Canadian scientist who discovered phages and pioneered their use as medicine over a century ago, leading them to be hailed as the world’s first genuine antibiotic years before penicillin. We learn why, in some pockets of the former Soviet Union, drinking a vial of phages remains as common as taking an over-the-counter drug. We follow the intrepid scientists and doctors now racing to make “phage therapy” work worldwide as the threat of antibiotic-resistant bacteria grows ever more urgent—even as other researchers uncover how phages bolster our everyday immunity, help generate the oxygen we breathe, and furnish the origins for breakthrough technologies like CRISPR. Unveiling the hidden rulers of the microbial world and celebrating the surprising power of viruses to heal, not harm, The Good Virus forever changes how we see nature’s most maligned life forms.
Phage Therapy Past Present And Future
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Author : Stephen T. Abedon
language : en
Publisher: Frontiers Media SA
Release Date : 2017-09-05
Phage Therapy Past Present And Future written by Stephen T. Abedon and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-05 with Electronic book categories.
Historically, the first observation of a transmissible lytic agent that is specifically active against a bacterium (Bacillus anthracis) was by a Russian microbiologist Nikolay Gamaleya in 1898. At that time, however, it was too early to make a connection to another discovery made by Dmitri Ivanovsky in 1892 and Martinus Beijerinck in 1898 on a non-bacterial pathogen infecting tobacco plants. Thus the viral world was discovered in two of the three domains of life, and our current understanding is that viruses represent the most abundant biological entities on the planet. The potential of bacteriophages for infection treatment have been recognized after the discoveries by Frederick Twort and Felix d’Hérelle in 1915 and 1917. Subsequent phage therapy developments, however, have been overshadowed by the remarkable success of antibiotics in infection control and treatment, and phage therapy research and development persisted mostly in the former Soviet Union countries, Russia and Georgia, as well as in France and Poland. The dramatic rise of antibiotic resistance and especially of multi-drug resistance among human and animal bacterial pathogens, however, challenged the position of antibiotics as a single most important pillar for infection control and treatment. Thus there is a renewed interest in phage therapy as a possible additive/alternative therapy, especially for the infections that resist routine antibiotic treatment. The basis for the revival of phage therapy is affected by a number of issues that need to be resolved before it can enter the arena, which is traditionally reserved for antibiotics. Probably the most important is the regulatory issue: How should phage therapy be regulated? Similarly to drugs? Then the co-evolving nature of phage-bacterial host relationship will be a major hurdle for the production of consistent phage formulae. Or should we resort to the phage products such as lysins and the corresponding engineered versions in order to have accurate and consistent delivery doses? We still have very limited knowledge about the pharmacodynamics of phage therapy. More data, obtained in animal models, are necessary to evaluate the phage therapy efficiency compared, for example, to antibiotics. Another aspect is the safety of phage therapy. How do phages interact with the immune system and to what costs, or benefits? What are the risks, in the course of phage therapy, of transduction of undesirable properties such as virulence or antibiotic resistance genes? How frequent is the development of bacterial host resistance during phage therapy? Understanding these and many other aspects of phage therapy, basic and applied, is the main subject of this Topic.
The Perfect Predator
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Author : Steffanie Strathdee
language : en
Publisher: Hachette UK
Release Date : 2019-02-26
The Perfect Predator written by Steffanie Strathdee and has been published by Hachette UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-26 with Science categories.
An electrifying memoir of one woman's extraordinary effort to save her husband's life-and the discovery of a forgotten cure that has the potential to save millions more. "A memoir that reads like a thriller." -New York Times Book Review "A fascinating and terrifying peek into the devastating outcomes of antibiotic misuse-and what happens when standard health care falls short." -Scientific American Epidemiologist Steffanie Strathdee and her husband, psychologist Tom Patterson, were vacationing in Egypt when Tom came down with a stomach bug. What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world. Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure. A nail-biting medical mystery, The Perfect Predator is a story of love and survival against all odds, and the (re)discovery of a powerful new weapon in the global superbug crisis.
Thinking Like A Phage
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Author : Merry Youle
language : en
Publisher:
Release Date : 2017-05
Thinking Like A Phage written by Merry Youle and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05 with Bacteriophages categories.
Phages are the most numerous life forms on Earth. Nevertheless, many people remain unaware of this dynamic, invisible world, and likewise of the challenges expertly met by every successful phage. This engaging book relates the ingenious tactics of 21 featured phages as they go about their viral work and replicate inside microbial cells.
Harnessing The Power Of Viruses
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Author : Boriana Marintcheva
language : en
Publisher: Academic Press
Release Date : 2017-11-13
Harnessing The Power Of Viruses written by Boriana Marintcheva and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-13 with Science categories.
Harnessing the Power of Viruses explores the application of scientific knowledge about viruses and their lives to solve practical challenges and further advance molecular sciences, medicine and agriculture. The book contains virus-based tools and approaches in the fields of: i) DNA manipulations in vitro and in vivo; ii) Protein expression and characterization; and iii) Virus- Host interactions as a platform for therapy and biocontrol are discussed. It steers away from traditional views of viruses and technology, focusing instead on viral molecules and molecular processes that enable science to better understand life and offer means for addressing complex biological phenomena that positively influence everyday life. The book is written at an intermediate level and is accessible to novices who are willing to acquire a basic level of understanding of key principles in molecular biology, but is also ideal for advanced readers interested in expanding their biological knowledge to include practical applications of molecular tools derived from viruses. Explores virus-based tools and approaches in DNA manipulation, protein expression and characterization and virus-host interactions Provides a dedicated focus on viral molecules and molecular processes that enable science to better understand life and address complex biological phenomena Includes an overview of modern technologies in biology that were developed using viral components/elements and knowledge about viral processes
Coral Reefs In The Microbial Seas
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Author : Forest Rohwer
language : en
Publisher: Plaid Productions
Release Date : 2010
Coral Reefs In The Microbial Seas written by Forest Rohwer and has been published by Plaid Productions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Science categories.
"The influence of fishing, nutrients, bacteria, viruses, and climate change on nature's most wondrous constructs"--Cover.
Biocommunication Of Phages
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Author : Guenther Witzany
language : en
Publisher: Springer Nature
Release Date : 2020-06-29
Biocommunication Of Phages written by Guenther Witzany and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-29 with Science categories.
This is the first book to systemize all levels of communicative behavior of phages. Phages represent the most diverse inhabitants on this planet. Until today they are completely underestimated in their number, skills and competences and still remain the dark matter of biology. Phages have serious effects on global energy and nutrient cycles. Phages actively compete for host. They can distinguish between ‘self’ and ‘non-self’ (complement same, preclude others). They process and evaluate available information and then modify their behaviour accordingly. These diverse competences show us that this capacity to evaluate information is possible owing to communication processes within phages (intra-organismic), between the same, related and different phage species (interorganismic), and between phages and non-phage organisms (transorganismic). This is crucial in coordinating infection strategies (lytic vs. lysogenic) and recombination in phage genomes. In 22 chapters, expert contributors review current research into the varying forms of phage biocommunication and Phagetherapy. Biocommunication of Phages aims to assess the current state of research, to orient further investigations on how phages communicate with each other to coordinate their behavioral patterns, and to inspire further investigation of the role of non-phage viruses (non-lytic, non-prokaryotic) in these highly dynamic interactional networks.
Phage Therapy Part A
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Author :
language : en
Publisher: Elsevier
Release Date : 2023-10-01
Phage Therapy Part A written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-01 with Science categories.
Phage Therapy - Part A, Volume 200 is an informative text on phage and their use for treatment in bacterial infections. The book highlights a number of aspects of the phage in a way that can help students, researchers, clinicians, entrepreneurs and stakeholders perform their research with great interest. Chapters in this new release cover An introduction to bacteriophage and their therapeutic applications, Isolation, screening and characterization of phage, Synthetic phage and their application in phage therapy, Phage engineering for development of diagnostic tools, Phage design and directed evolution to evolve phage for therapy, and more. Additional sections cover Host-phage interactions and modelling for therapy, Phage and phage cocktails formulations, Phage for treatment of Escherichia coli infection, Phage for treatment of Klebsiella pneumoniae infection, Phage for treatment of Salmonella spp infection, Phage for treatment of Staphylococcus aureus infection, and Phages for treatment of Acinetobacter baumannii infection. Includes discussions on phage isolation, screening and characterization Covers synthetic phage, phage for diagnostic, directed evolution and host interaction Presents the latest on phage for treatment of bacterial infections