Lipid A In Cancer Therapy
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Lipid A In Cancer Therapy
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Author : Jean-Francois Jeannin
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-07-28
Lipid A In Cancer Therapy written by Jean-Francois Jeannin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-28 with Medical categories.
Cancer remains a major challenge for modern society. Not only does cancer rank among the first three causes of mortality in most population groups but also the therapeutic options available for most tumor types are limited. The existing ones have limited efficacy, lack specificity and their administration carry major side effects. Hence the urgent need for novel cancer therapies. One of the most promising avenues in research is the use of specific immunotherapy. The notion that the immune system may have important anti-tumor effects has been around for more than a century now. Every major progress in microbiology and immunology has been immediately followed by attempts to apply the new knowledge to the treatment of cancer. Progress has reached a point where it is well established that most cancer patients mount specific T cell responses against their tumors. The molecular identity of the antigens recognized by anti-tumor T cells has been elucidated and several hundreds of tumor-derived antigenic peptides have been discovered. Upon recognition of such peptides presented by self MHC molecules, both CD8 and CD4 T cells are activated, expand to high numbers and differentiate into effective anti-tumor agents. CD8 T cells directly destroy tumor cells and can cause even large tumors to completely regress in experimental mouse models. These observations have spurred intense research activity aimed at designing and testing cancer vaccines. Over 100 years ago Coley successfully used intratumoral injection of killed bacteria to treat sarcomas. The important anti-tumor effects observed in a fraction of these patients fueled major research efforts. These led to major discoveries in the 80s and the 90s. It turns out that bacterial lipopolysaccharides stimulate the production of massive amounts of a cytokine still known today as tumor necrosis factor (TNF-a). They do so by engagement of a rather complex set of interactions culminating in the ligation of a Toll-like receptor, TLR -4. Ensuing signaling through this receptor initiates potent innate immune responses. Unfortunately the clinical use of both TNF-a and LPS can not be generalized due to their very narrow therapeutic margin. Importantly, synthetic Lipid A analogs have been identified that retain useful bioactivity and yet possess only mild toxicity. The relatively large body of information accumulated thus far on the molecular and cellular interactions set in motion by administration of LPS as well as by the synthetic lipid A analogs allow to place this family of bacterially-derived molecules at the crossroads between innate and adaptive immunity. By virtue of this key position, the therapeutic applications being pursued aim at using these compounds either as direct anti-tumor agents or as vaccine adjuvants. The clinical experience acquired so far on these two avenues is asymmetric. Few clinical trials using Lipid A analogs as single anti-cancer agents involving less than 100 patients with advanced cancer have been reported. In contrast, lipid A has been tested in over 300,000 individuals in various vaccines trials, including therapeutic cancer vaccines. Clearly most of the work needed to develop lipid A as effective anti-cancer agents and/or as vaccine adjuvant lies ahead in the near future. This book is a timely contribution and provides a much needed up-to-date overview of the chemical, biological and physiological aspects of lipid A. It should be a beacon to all those involved in this field of research.
Therapeutic Platform Of Bioactive Lipids
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Author : Manjari Singh
language : en
Publisher:
Release Date : 2023
Therapeutic Platform Of Bioactive Lipids written by Manjari Singh and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Cancer categories.
"Bioactive lipid metabolism and signaling are now widely accepted as major players in cancer biology. This volume, Therapeutic Platform of Bioactive Lipids: Focus on Cancer, helps to fill the urgent need to explore and investigate the innovations, current shortcomings, and future challenges of cancer therapy through the bioactive lipids by presenting new research on the use of bioactive lipids as effective weapons against cancer. The volume introduces the subject and then goes on to cover the chemistry, formulation, and mechanism of bioactive lipids in cancer. The volume takes a close look at lipoxins, ceramides, resolvins, and sphingosine-1-phosphate and their roles in cancer treatment. It also addresses the formulations based on bioactive lipids for the treatment of cancer. A variety of mechanisms of bioactive lipids as novel therapies are also covered, including using computational techniques to identify bioactive lipid drug targets, targeting therapy via KRAS and PI3K signals, and others. The authors also discuss the role and effects of various substances and their effect on various cancers, including colorectal cancer, prostate cancer, breast cancer, and others. The application of lysophosphatidic acid, lipopolysaccharide, lipid-soluble bioactive substance from avocado, omega-3 polyunsaturated fatty acids-derived lipid metabolites, and more are covered as well. The volume offers academia, technologists, and scientists from different disciplines valuable information to gain knowledge of bioactive lipid metabolism and signaling as an anti-cancer weapon in their fight against cancer."--
Functional Lipid Nanosystems In Cancer
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Author : Marlene Lúcio
language : en
Publisher: CRC Press
Release Date : 2021-11-30
Functional Lipid Nanosystems In Cancer written by Marlene Lúcio and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-30 with Medical categories.
Cancer remains one of the most challenging issues in modern medicine, being responsible for a high number of deaths every year. Recent important developments in cancer diagnosis and therapy based on the versatility of nanosystems have made it possible to incorporate multifunctional synergistic actions into a single delivery system. This book compiles the research on the use of functional lipid nanosystems that combine different strategies in one single nanosystem to enhance overall cancer treatment. Besides providing an overview of the current functional nanosystem strategies, it also offers researchers essential theoretical background on cancer, the physiological barriers to its treatment, aspects related to the design and optimization of nanocarriers for cancer treatment, and clinical developments, including promises, safety issues, and the expected future. The editors bring together a group of scientists from all over the world to discuss the most relevant issues and to provide updates on functional lipid nanosystems and cancer.
Lipid Nanocarriers In Cancer Diagnosis And Therapy
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Author : Eliana Souto
language : en
Publisher: Smithers Rapra
Release Date : 2011-06-30
Lipid Nanocarriers In Cancer Diagnosis And Therapy written by Eliana Souto and has been published by Smithers Rapra this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-30 with Medical categories.
Lipid Nanocarriers in Cancer Diagnosis and Therapy fills a need for an accurate, coherent and authoritative introduction to lipid nanocarriers focusing in cancer therapy; both because of the growing popularity of these modern drug delivery systems and also because of the emergent need of dealing with cancer treatment. This handbook deals with lipid nanocarriers for targeted delivery to tumours of various organs and combination of these with other methods of treatment of cancer such as radiotherapy, diagnostic and imaging analysis. Lipid nanocarriers are also used for gene therapy for cancer.
Lipid Nanoparticles For Mrna Mediated Cancer Therapy
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Author : Dania Grant-Serroukh
language : en
Publisher:
Release Date : 2019
Lipid Nanoparticles For Mrna Mediated Cancer Therapy written by Dania Grant-Serroukh and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
The use of messenger ribonucleic acid (mRNA) to introduce protein sequences into cells, expressing cytokines or antigens, is a promising therapeutic strategy in the oncology field. However, advancement of this technology is stalled by the lack of an effective delivery system. Developing mRNA-specific vectors, along with improving understanding of vector structure and fundamental cellular uptake mechanisms, should allow further progress in moving mRNA therapy to the clinic. This work investigates the use of lipid-peptide based vectors for the delivery of mRNA both in vitro and in vivo. The components of the vector were optimised to produce high levels of transfection in B16 melanoma cells. The resultant formulation comprised of the cationic lipid C14, the phospholipid DOPE, cholesterol and peptide 35. This formulation transfected a number of cancer cells types, producing high levels of expression of luciferase and green fluorescent protein. Formulations were characterised using dynamic light scattering, small-angle X-ray scattering, electron and atomic force microscopy to elucidate the structure of vectors. The nanocomplex had a spherical morphology and appeared to comprise an external lipid membrane with mRNA and/or peptides present on the surface. Optimal particles showed resistance to degradation and aggregation for up to 28 days at 4 oC and showed no loss of activity in the presence of RNase. Finally, mRNA uptake kinetics and trafficking were explored using fluorescent microscopy where no differences between optimal and non-optimal formulations were found; suggesting the key factor affecting performance was endosomal escape. Overall, the peptide-lipid-mRNA system was shown to be a promising platform for further investigation of mRNA delivery in vivo.
Eicosanoids And Other Bioactive Lipids In Cancer And Radiation Injury
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Author : Kenneth V. Honn
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Eicosanoids And Other Bioactive Lipids In Cancer And Radiation Injury written by Kenneth V. Honn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume contains the proceedings of the First International Conference on Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury held in Detroit, Michigan on October 11-14, 1989. The program consisted of 83 oral and 29 poster presentations, 74 of which are included in these proceedings. The major sponsors of the conference were the Armed Forces Radiobiology Research Institute, located in Bethesda, Maryland, the Radiation Oncology Research and Development Center of the Gershenson Radiation Oncology Center, Harper Hospital in Detroit, Michigan, and Schering AG of West Germany. Eighteen other organizations provided additional support. The conference was unique in its attempt to link the eicosanoid and lipid researchers in the radiobiology and cancer disciplines. The diverse roles that eicosanoids and other bioactive lipids play in these biological phenomena including the participation of lipid oxidation in conversion of procarcinogens, positive and negative modulation of tumor growth, immunomodulation, tissue injury, and yet protection and enhancement of cancer therapy, necessitated scientific interaction to sort out and understand these complex and sometimes contradictory observations. The success of this effort is reflected not only through these proceedings, but also through the decision to continue the conference series with a second meeting to be held in Berlin between September 17-21, 1991.
The Role Of Bioactive Lipids In Cancer Inflammation And Related Diseases
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Author : Kenneth V. Honn
language : en
Publisher: Springer Nature
Release Date : 2019-09-27
The Role Of Bioactive Lipids In Cancer Inflammation And Related Diseases written by Kenneth V. Honn and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-27 with Medical categories.
The Organizing Committee of the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases compiled a group of junior investigators to provide reviews on the topics they presented at the Puerto Vallarta Bioactive Lipids conference, as part of the book series, Advances in Experimental Medicine and Biology (AEMB). The book in this series will be titled Bioactive Lipids in Cancer, Inflammation and Related Diseases. Topics range from all classes of lipids including prostaglandins, resolvins, spingolipids, P450-derived lipids, endocannabanoids and phospholipids. The focus includes physiology, cell biology, and structural studies in organisms from bacteria to humans and how these studies addressed the role of lipids in various disease i.e. cancer, inflammation, diabetes, obesity, cardiovascular disease and others.
Lipid Nanocarriers In Cancer Diagnosis And Therapy
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Author : Eliana B. Souto
language : en
Publisher:
Release Date : 2011
Lipid Nanocarriers In Cancer Diagnosis And Therapy written by Eliana B. Souto and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Cancer categories.
This book introduces fundamental principles of lipid nanocarriers science relevant to cancer therapy. The first in this field, it fills a need for an accurate, coherent and authoritative introduction to lipid nanocarriers focusing in cancer therapy; both because of the growing popularity of these modern drug delivery systems and also because of the emergent need of dealing with cancer treatment. Active drug delivery and targeting using nanobiotechnologies has become one of the most successful strategies to approach chemotherapy. This book deals with lipid nanocarriers for targeted delivery to.
The Role Of Sphingolipids In Cancer Development And Therapy
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-12-31
The Role Of Sphingolipids In Cancer Development And Therapy written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Medical categories.
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "The Role of Sphingolipids in Cancer Development and Therapy" Provides invaluable information on the exciting and fast-moving field of cancer research This thematic volume looks at "The Role of Sphingolipids in Cancer Development and Therapy" Outstanding and original reviews
Functional Lipid Nanosystems In Cancer
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Author : Marlene Lúcio
language : en
Publisher:
Release Date : 2021-11-30
Functional Lipid Nanosystems In Cancer written by Marlene Lúcio and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-30 with Cancer categories.
This book compiles the research on the use of functional lipid nanosystems that combine different strategies in one single nanosystem to enhance overall cancer treatment. Besides providing an overview of the current functional nanosystem strategies, it also offers researchers essential theoretical background on cancer.