Lipid Rafts And Development Of Alzheimer S Disease
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Lipid Rafts And Development Of Alzheimer S Disease
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Author : Mario Díaz
language : en
Publisher:
Release Date : 2022
Lipid Rafts And Development Of Alzheimer S Disease written by Mario Díaz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Medical categories.
A wealth of evidence accumulated over the last two decades has unambiguously linked lipid rafts to neurodegenerative diseases, in particular to Alzheimer,Äôs disease (AD). These microdomains are highly dynamic membrane platforms with differentiated physicochemical and molecular properties compared to the surrounding membrane microenvironment, and are the locus for a number of central processes¬†in neuronal physiology. Most recent evidence pinpoint to lipid rafts as main players in AD neuropathology. It is now widely accepted that lipid rafts actively participate in the processing of amyloid precursor protein to generate amyloid beta peptides, a main component of amyloid plaques. Current evidence have highlighted the existence of severe alterations in the molecular structure and functionality of lipid rafts in the frontal cortex of human brains affected by Alzheimer,Äôs disease. An exceptionally interesting observation is that lipid raft destabilization can be demonstrated even at the earliest stages of AD neuropathology. In the present review, we will first elaborate on the structure and function of these multifaceted subcellular structures and second to focus on the impact of their alterations in neuronal pathophysiology along the onset and progression of AD continuum.
Structural And Functional Aspects Of Membranes
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Author : Elisa Evangelisti
language : en
Publisher:
Release Date : 2013
Structural And Functional Aspects Of Membranes written by Elisa Evangelisti and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Cerebral And Cerebellar Cortex
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Author : Stavros J. Baloyannis
language : en
Publisher:
Release Date : 2021
Cerebral And Cerebellar Cortex written by Stavros J. Baloyannis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Brain categories.
Cerebral and Cerebellar Cortex - Interaction and Dynamics in Health and Disease discusses several important issues of cerebro-cerebellar collaboration and interactions. The morphological and functional study of the cerebral and cerebellar cortices and their interaction has considerable value for interpreting the clinical phenomenology of cortical degenerations in the initial stage of the disease. In addition, the analysis of cerebro-cerebellar interactions strongly supports the concept of the close functional unity and harmonization of the brain and the cerebellum, underlining the important role that the cerebellar cortex plays in the performance of higher mental faculties, creativity, emotional processes, and homeostatic equilibrium of the human body.
The Role Of Lipid Rafts On The Trafficking And Processing Of The Amyloid Precursor Protein
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Author : Christopher Towlson
language : en
Publisher:
Release Date : 2010
The Role Of Lipid Rafts On The Trafficking And Processing Of The Amyloid Precursor Protein written by Christopher Towlson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Alzheimer's disease categories.
Alzheimer's disease (AD) brain pathology is characterised by the presence of senile plaques containing insoluble aggregates of the amyloid beta peptide (A[beta]). The mechanisms of A[beta] generation are not well understood but previous work has shown that amyloid precursor protein (APP) internalization from the cell surface may be an important step in this process. APP and the amyloidogenic enzymes involved in its processing have been shown to reside in cholesterol rich membrane micro-domains called lipid rafts. Lipid rafts are important cell signalling centres on the plasma membrane and may be involved in certain types of endocytosis. APP processing, including endocytosis, is also modulated by insulin signalling pathways. This thesis describes the generation and expression of APP endocytosis deficient mutants to study the role of APP intemalisation, insulin signalling and lipid rafts in A[beta] generation. -- Subcellular fractionation of cultured cells expressing human APP reveals that [beta]CTF, the direct precursor to A[beta], is found almost exclusively in lipid raft fractions. Furthermore, [beta]CTF is reduced in lipid rafts from cells expressing endocytosis deficient APP mutants. By contrast, APP endocytosis mutations have no effect on the localization of full-length APP or [beta]- and [gamma]-secretases. We also show that insulin treatment increases non-amyloidogenic processing of APP in neuroblastoma cells and primary mouse neurons, possibly by a mechanism involving decreased APP endocytosis. - Taken together, my results are consistent with the notion that plasma membrane bound APP and the [beta]-secretase BACE reside in distinct lipid raft species that merge upon endocytosis, resulting in enzyme and substrate converging in endosomes where APP is cleaved to generate A[beta]. Furthermore, altered APP endocytosis due to insulin resistance may increase the generation of A[beta] in AD.
Neurodegeneration And Alzheimer S Disease
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Author : Ralph N. Martins
language : en
Publisher: John Wiley & Sons
Release Date : 2019-07-10
Neurodegeneration And Alzheimer S Disease written by Ralph N. Martins and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-10 with Technology & Engineering categories.
Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.
Cellular Peptidases In Immune Functions And Diseases 2
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Author : Jürgen Langner
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-11
Cellular Peptidases In Immune Functions And Diseases 2 written by Jürgen Langner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-11 with Medical categories.
Of the many special roles played by proteolytic enzymes in immune reactions, this book addresses different aspects of membrane peptidases, signal transduction via ligation of membrane peptidases (especially of dipeptidyl peptidase IV/CD26 and aminopeptidase N/CD13), and regulation of membrane peptidases in vivo and in vitro. A number of newly discovered peptidases (including cathepsin F, W and X, carboxypeptidase X, attractin) are described, with special emphasis given to the role of peptidases in immune and defense reactions and in the pathogenesis of inflammatory and other diseases, including rheumatoid arthritis, pancreatitis, multiple sclerosis, Alzheimer's disease and tumours of various origins. The focus on the involvement of a selection of proteolytic enzymes in immune reactions and diseases is a unique feature of this multifaceted work , which combines biochemical, immunological and clinical research reports with literary reviews of the field.
Lipid Domains
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Author :
language : en
Publisher: Academic Press
Release Date : 2015-06-08
Lipid Domains written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-08 with Science categories.
Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up to date presentation of current knowledge in the field of Lipid Domains. Written by leading experts Contains original material, both textual and illustrative, that should become a very relevant reference material The material is presented in a very comprehensive manner Both researchers in the field and general readers should find relevant and up-to-date information
Developing Therapeutics For Alzheimer S Disease
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Author : Michael S. Wolfe
language : en
Publisher: Academic Press
Release Date : 2016-05-27
Developing Therapeutics For Alzheimer S Disease written by Michael S. Wolfe and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-27 with Medical categories.
Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics. Provides a realistic but promising assessment of the potential of various therapeutic approaches to Alzheimer’s disease Focuses primarily on neuroprotective agents and cognitive enhancers, as well as approaches to targeting the amyloid B-peptide, tau and Apolipoprotein E Discusses alternative approaches, preclinical and clinical development issues, related biomarkers and diagnostics, and prevention and nonpharmacological approaches
Intracellular Cholesterol Trafficking
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Author : T.Y. Chang
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Intracellular Cholesterol Trafficking written by T.Y. Chang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
INTRODUCTION AND RATIONALE FOR INTRACELLULAR CHOLESTEROL TRAFFICKING This volume is an elaboration of an earlier small meeting held in St. Louis, Missouri. In April 1997, many of the authors met for a two-day meeting devoted entirely to intracellular cholesterol trafficking. The rationale for this meeting was that investigators interested in this topic worked in a variety of fields, and rarely, if ever, all met together. Everybody knew each other's papers but mostly worked in isolation from one another. Understanding of cholesterol trafficking also appeared to have reached the point where it would start to rapidly expand beyond these few laboratories. Understanding of cholesterol trafficking was moving from a largely descriptive science into the molecular age. It seemed a good time to get together and see how much we agreed upon up to this point. More authors contributed to this volume than attended the St. Louis meeting. That meeting was generously funded by grants from Bristol-Myers Squibb, Merck and Company and Parke-Davis, however, the total funding available limited the size of the meeting. For the book, we are not so limited and have tried to be as inclusive as possible and pretty much invited everyone who is presently active in this area. We were quite fortunate to successfully recruit the authors we sought for each of these chapters. The authors and their contributions can be organized by particular interests and particular areas of expertise.
Neurodegenerative Diseases
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Author : Uday Kishore
language : en
Publisher: BoD – Books on Demand
Release Date : 2013-05-15
Neurodegenerative Diseases written by Uday Kishore and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-15 with Medical categories.
This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.