Long Acting Injections And Implants
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Long Acting Injections And Implants
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Author : Jeremy C. Wright
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-29
Long Acting Injections And Implants written by Jeremy C. Wright and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-29 with Medical categories.
Long acting injections and implants improve therapy, enhance patient compliance, improve dosing convenience, and are the most appropriate formulation choice for drugs that undergo extensive first pass metabolism or that exhibit poor oral bioavailability. An intriguing variety of technologies have been developed to provide long acting injections and implants. Many considerations need to go into the design of these systems in order to translate a concept from the lab bench to actual therapy for a patient. This book surveys and summarizes the field. Topics covered in Long Acting Injections and Implants include the historical development of the field, drugs, diseases and clinical applications for long acting injections and implants, anatomy and physiology for these systems, specific injectable technologies (including lipophilic solutions, aqueous suspensions, microspheres, liposomes, in situ forming depots and self-assembling lipid formulations), specific implantable technologies (including osmotic implants, drug eluting stents and microfabricated systems), peptide, protein and vaccine delivery, sterilization, drug release testing and regulatory aspects of long acting injections and implants. This volume provides essential information for experienced development professionals but was also written to be useful for scientists just beginning work in the field and for others who need an understanding of long acting injections and implants. This book will also be ideal as a graduate textbook.
Long Acting Injections And Implants
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Author : Jeremy C. Wright
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-12-14
Long Acting Injections And Implants written by Jeremy C. Wright and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-14 with Medical categories.
This book surveys the field of long acting injections and implants, which improve therapy, enhance patient compliance, and enhance dosing convenience. Topics include the historical development of drugs and diseases, and clinical applications for long acting injections and implants.
Biodegradable Long Acting Injectables And Implants
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Author : Farshad Ramazani
language : en
Publisher: Springer Nature
Release Date : 2025-03-29
Biodegradable Long Acting Injectables And Implants written by Farshad Ramazani and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-29 with Science categories.
Long acting injectables and implants (LAI) are known to improve patient adherence and treatment outcomes. They reduce costs for the healthcare system and ensure sustainable sales for pharmaceutical companies. LAI are usually administered intramuscularly (IM) or subcutaneously (SC). In this way, the drug is released from its depot in a controlled manner over a longer period of time (e.g., a few days to a year). There is a trend toward increasing interest in the development of long-acting drugs for local administration versus systemic administration of depot products (i.e., IM or SC injection). This is leading to finding new ways of administration of the depot formulation, intra-ocular, intra-articular, pri-tendon etc. Therefore, it is expected that more drugs based on LAI formulations will enter the clinical phase in the future. Due to many benefits in adherence, efficacy, and safety of the treatment up until now around 50 brand name medicines using different biodegradable long-acting technology have received FDA approval. Manufacturing of LAI involves many steps with their unique challenges, which is why pharmaceutical companies consider them to be complex formulations to develop. Most of the published papers and books in this field are written by scientists who never worked in industry and whose knowledge on the topic is limited to small scale formulation screening. Therefore, this book aims to address the challenges of the development of biodegradable LAI from an industrial perspective.
Principles Of Tissue Engineering
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Author : Robert Lanza
language : en
Publisher: Academic Press
Release Date : 2020-03-26
Principles Of Tissue Engineering written by Robert Lanza and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-26 with Science categories.
Now in its fifth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fifth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world's experts of what is currently known about each specific organ system. As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future. This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and the application of tissue-engineering techniques for food production – is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the emerging technologies in the field. - Organized into twenty-three parts, covering the basics of tissue growth and development, approaches to tissue and organ design, and a summary of current knowledge by organ system - Introduces a new section and chapters on emerging technologies in the field - Full-color presentation throughout
Innovative Delivery Systems For Paediatric Medicines
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Author : Jenny Walsh (Pharmacist)
language : en
Publisher: World Health Organization
Release Date : 2021-11-10
Innovative Delivery Systems For Paediatric Medicines written by Jenny Walsh (Pharmacist) and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-10 with Medical categories.
Provided in this landscape analysis is an overview of new and emerging dosage forms and formulation technologies that may be beneficial if applied for use in paediatric patients. It covers various routes of administration including oral, rectal, parenteral, transdermal and others. There is also attention given to long-acting formulations that hold clear promise for use in children. Emphasis is placed upon those dosage forms and technologies which could be suitable for use for children in LMICs. There are key considerations when analysing potential application of these technologies to existing and emerging therapeutic needs for children. Some technologies are ready and available to use in an intervention today, while others will require further investigations. As a result, strategic interventions and investments in this area can be classified by opportunities in the short-term and in the long-term. There are near-term opportunities for the development of age-appropriate solid oral dosage forms including dispersible tablet formulations and oro-dispersible tablets. Also, suppositories and long-acting depot injectables offer potential alternatives and are gaining interest. Well established technologies for controlling and delaying release and for enhancing the bioavailability of poorly soluble drugs are all considered to provide near term opportunities. On the longer term, further evaluation of the safety and acceptability of some of the dosage forms and technologies in paediatric patients are required, as well as, the feasibility for cost-effective commercialisation. (i.e., oro-dispersible and buccal films, long acting implants, and needle-free injections).
Neuroimmune Pharmacology And Therapeutics
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Author : Howard E. Gendelman
language : en
Publisher: Springer Nature
Release Date : 2024-12-26
Neuroimmune Pharmacology And Therapeutics written by Howard E. Gendelman and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-26 with Medical categories.
Bridging neuroscience, immunology, and pharmacology, and bringing together the foremost authorities, Neuroimmune Pharmacology and Therapeutics, 3rd edition, is an invaluable reference and textbook. The text discusses the immunology of the nervous system. New chapters are offered on innate, humoral, and cellular immune responses (innate and adaptive immunity). The additions join each component of the immune response in descriptions for how each affects nervous system function in both health and disease. Next, discussions of neuropharmacology now include both drug development and delivery into brain subregions to optimize clinical responses. This edition features greatly expanded coverage of therapeutics. The new extensions have blossomed into focused therapies engaging the immune system directly, deploying it for drug delivery, attracting the newly evolving field of genetics, vaccinations, and bioengineering, ultimately leading to improved therapeutic disease outcomes. All of the revisions in this edition are designed to bring an early trainee together with a skilled clinical and translational scientist to discuss the state of the art in each part of the emerging field of immunity as it affects the nervous system during steady state and disease and how it can be harnessed for therapeutics and clinical benefit.
Drug Delivery
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Author : Anya Hillery
language : en
Publisher: CRC Press
Release Date : 2016-09-15
Drug Delivery written by Anya Hillery and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-15 with Medical categories.
This book provides a comprehensive introduction to advanced drug delivery and targeting, covering their principles, current applications, and potential future developments. This edition has been updated to reflect significant trends and cutting-edge advances that have occurred since the first edition was published. All the original chapters have been retained, but the material therein has been updated. Eight new chapters have been added that deal with entirely new technologies and approaches. Features: Offers a comprehensive introduction to the fundamental concepts and underlying scientific principles of drug delivery and targeting Presents an in-depth analysis of the opportunities and obstacles afforded by the application of nanotechnologies for drug delivery and targeting Includes a revised and expanded section on the major epithelial routes of drug delivery currently under investigation Describes the most recent, emerging, and innovative technologies of drug delivery Provides real-life examples of the clinical translation of drug delivery technologies through the use of case studies Discusses the pertinent regulatory hurdles and safety issues of drug delivery and targeting systems—crucial considerations in order to achieve licensing approval for these new technologies
Applications Of Nanocomposite Materials In Drug Delivery
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Author : Inamuddin
language : en
Publisher: Woodhead Publishing
Release Date : 2018-06-18
Applications Of Nanocomposite Materials In Drug Delivery written by Inamuddin and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-18 with Technology & Engineering categories.
Applications of Nanocomposite in Drug Delivery discusses and explores the applications of nanocomposites in the area of drug delivery. Starting with a scientific understanding of drug delivery fundamentals, the book explores the utility of nanocomposites in the area of controlled, transdermal, osteo-articular tuberculosis and stimulus sensitive drug delivery applications. The book intricately details and discusses a variety of methods for their preparation, while also highlighting specific applications of nanocomposites in targeted drug delivery. - Discusses nanocomposite and nanotechnology for drug delivery - Outlines the mechanisms involved in targeted drug delivery using nanocomposites - Includes synthesis methods for nanocomposites used in controlled drug delivery - Lists various applications of nanocomposites in drug delivery
Handbook Of Research On Functional Materials
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Author : Charles A. Wilkie
language : en
Publisher: CRC Press
Release Date : 2014-02-06
Handbook Of Research On Functional Materials written by Charles A. Wilkie and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-06 with Technology & Engineering categories.
Handbook of Research on Functional Materials: Principles, Capabilities and Limitations covers a broad range of modern materials and provides industry professionals and researchers in polymer science and technology with a single, comprehensive book summarizing all aspects involved in the modern materials production chain. The book focuses on industrially important materials, analytical techniques, and formulation methods, with chapters covering step-growth, radical, and co-polymerization, crosslinking and grafting, reaction engineering, advanced technology applications, including conjugated, dendritic, and nanomaterial polymers and emulsions, and characterization methods, which includes spectroscopy, light scattering, and microscopy. The book introduces current state-of-the-art technology in modern materials with an emphasis on the rapidly growing technologies. It takes a unique approach by presenting specific materials and then progresses into a discussion of the ways in which these materials and processes are integrated into today’s functioning manufacturing industry. It follows a more quantitative and design-oriented approach than other texts in the market, helping readers gain a better understanding of important concepts. Readers will also discover how material properties relate to the process variables in a given process as well as how to perform quantitative engineering analysis of manufacturing processes.
International Handbook On Adolescent Health And Development
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Author : Andrew L. Cherry
language : en
Publisher: Springer
Release Date : 2016-11-21
International Handbook On Adolescent Health And Development written by Andrew L. Cherry and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-21 with Medical categories.
This comprehensive reference uses an ecological perspective to sort out the complex mix of biological, psychological, social, and other factors influencing adolescent health as well as shaping professional responses to the needs of adolescents. Describing critical concerns at the global level and innovative strategies from selected countries, the book urges readers to develop and support practices and policies to enhance optimal youth development. Expert coverage centers on key areas: the global state of adolescent health and development, adolescent health issues and public health answers, making health systems more responsive to youth, and improving school health services. And bedrock themes such as social determinants of health, young people’s right to health care, and health and gender disparities are discussed throughout these chapters. Included among the topics: • The epidemiology of adolescent health • Adolescent sexual health and sexuality education • Restorative justice and the mental wellbeing of adolescents • Critical issues in adolescent nutrition: needs and recommendations • Towards an adolescent competent workforce • Pairing children with health services: the changing role of school health services in the 21st century The International Handbook on Adolescent Health and Development is essential to medical schools, public schools, and college libraries; teaching faculty; graduate and post-graduate students in public health, medicine, social work, other behavioral sciences and health disciplines (e.g., nursing, allied heath); as well as practitioners interested in better orienting their services to the health needs of adolescents.