Low Voltage Activated T Type Calcium Channels
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Low Voltage Activated T Type Calcium Channels
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Author : Richard W. Tsien
language : en
Publisher:
Release Date : 1998
Low Voltage Activated T Type Calcium Channels written by Richard W. Tsien and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Calcium categories.
T Type Calcium Channels In Basic And Clinical Science
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Author : Stephen W. Schaffer
language : en
Publisher: Springer
Release Date : 2014-11-26
T Type Calcium Channels In Basic And Clinical Science written by Stephen W. Schaffer and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-26 with Science categories.
T-type calcium channels are prevalent in every organ of the body, and are believed to play a part in a variety of physiological processes, including contraction, shape change, secretion, endo- and exocytosis, cell proliferation and differentiation, modulation of enzyme function, and cell cycle progression. As such, research on the roles of these channels in a wide range of diseases has attracted increasing attention in recent years. The purpose of this book is to present a series of unique and comprehensive reviews of our current understanding of T-type calcium channels at the level of the basic sciences as well as the clinical sciences. For key organ systems, information is provided on the correlation between the molecular, biophysical and pharmacological properties of the channels, their cellular mechanisms, and their potential roles in the pathogenesis of various diseases. The compilation presents both commonplace and less well-known findings on these channels in a format designed to appeal to both casual readers and specialists in basic and clinical research on these transporters.
Voltage Gated Calcium Channels
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Author : Gerald Werner Zamponi
language : en
Publisher: Springer Nature
Release Date : 2022-11-07
Voltage Gated Calcium Channels written by Gerald Werner Zamponi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-07 with Science categories.
This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.
The Role Of Sodium And Calcium Permeable T Type Channels In Generating Pacemaking Currents In Invertebrates
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Author : Jennifer Czekus
language : en
Publisher:
Release Date : 2016
The Role Of Sodium And Calcium Permeable T Type Channels In Generating Pacemaking Currents In Invertebrates written by Jennifer Czekus and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Calcium channels categories.
T-type calcium channels (Cav3) play a key role in generating rhythmic action potentials in excitable cells such as the heart pacemaker and sleep-wake cycles in the thalamus. T-type channels are low voltage-activated channels, which can be opened near rest to cause an inward current that leads to membrane voltage rising to threshold to generate rhythmic action potential ring. The upstroke of the ventricular action potential in the vertebrate heart is attributed mostly to the cardiac-specfi c voltage-gated sodium channel, Nav1.5. Sodium channels are not expressed in the invertebrate heart, such as Lymnaea stagnalis. Instead, the major inward conductances of the invertebrate heart are due to voltage-gated calcium channels. The invertebrate pond snail, Lymnaea stagnalis, heart expresses T-type calcium channel, LCav3, which is alternatively-spliced in exon 12, generating a highly sodium selective T-type channel (with exon 12a) compared to a more calcium ion selective channel isoform (with exon 12b). The sodium permeant, LCav3-12a channel is the only T-type channel expressed in the heart, while LCav3-12b is more exclusive to the secretory glands, such as prostate and albumen. Our goal is to understand the functional consequence of differing sodium and calcium ion selectivities of T-type channels for the generation of rhythmic pacemaking in native tissues by conducting elecrophysiology experiments on dissociated ventricle cells and constructing a qualitative mathematical model of the invertebrate ventricular action potential. Mathematical models for both LCav3-12a and LCav3-12b T-type currents were constructed and implemented using current models from the Kyoto model, a guinea pig ventricular action potential model, to reflect the currents found in Lymnaea stagnalis. LCav3-12b had a smaller pacemaking current and showed slower rate of spike generation opposed to LCav3-12a which had a larger current and faster pacemaking activity. Spiking activity was not abolished with simulated T-type current block but had the greatest effect on rate of pacemaking. Simulations involving reduced current conductance or varying ion concentration show that LCav3 was primarily responsible for generating pacemaking activity and initiating the action potential upstroke.
T Type Calcium Currents In Spinal Sensory Integration
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Author : Wen-hsin Ku
language : en
Publisher:
Release Date : 2010
T Type Calcium Currents In Spinal Sensory Integration written by Wen-hsin Ku and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Calcium categories.
Calcium Entry Channels In Non Excitable Cells
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Author : Juliusz Ashot Kozak
language : en
Publisher: CRC Press
Release Date : 2017-07-14
Calcium Entry Channels In Non Excitable Cells written by Juliusz Ashot Kozak and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-14 with Science categories.
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Jasper S Basic Mechanisms Of The Epilepsies
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Author : Jeffrey Noebels
language : en
Publisher: OUP USA
Release Date : 2012-06-29
Jasper S Basic Mechanisms Of The Epilepsies written by Jeffrey Noebels and has been published by OUP USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-29 with Medical categories.
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Ion Channels In Health And Sickness
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Author : Fatima Shad Kaneez
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-10-10
Ion Channels In Health And Sickness written by Fatima Shad Kaneez and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-10 with Science categories.
Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.
Store Operated Calcium Channels
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Author :
language : en
Publisher: Academic Press
Release Date : 2013-07-24
Store Operated Calcium Channels written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-24 with Science categories.
Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject
Structure Function Relationship And Modulation Of The T Type Calcium Channel 1g
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Author : Karel Talavera Perez
language : en
Publisher: Leuven University Press
Release Date : 2004-09
Structure Function Relationship And Modulation Of The T Type Calcium Channel 1g written by Karel Talavera Perez and has been published by Leuven University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-09 with Calcium channels categories.