Lymph Node T Cell Dynamics And Novel Strategies For Hiv Cure
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Lymph Node T Cell Dynamics And Novel Strategies For Hiv Cure
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Author : Constantinos Petrovas
language : en
Publisher: Frontiers Media SA
Release Date : 2019-02-11
Lymph Node T Cell Dynamics And Novel Strategies For Hiv Cure written by Constantinos Petrovas and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-11 with categories.
Currently, more than 36 million people are infected with HIV. Although the introduction of highly active anti-retroviral therapy (HAART) has led to substantial advances in the clinical management of HIV infected individuals, HAART cannot completely eliminate the virus. This is because CD4 T helper cells, harboring the virus, remain dormant reservoirs. These reservoirs are difficult to measure and are present even in HAART-treated HIV infected individuals with undetectable levels of HIV in the blood. A growing body of studies has revealed follicular helper (Tfh) CD4 T cells, a highly differentiated CD4 T cell population localized in immunologically sanctuary sites (follicle/germinal center), as a major reservoir of HIV. The present Frontiers in Immunology eBook compiles 16 timely review articles focusing on the dynamics of major follicular immune cell types in HIV/SIV infection and their potential role for disease pathogenesis and the viral persistence in the lymph node. This eBook provides a comprehensive presentation of recent published work on lymph node and especially Tfh cell dynamics in HIV infection and we hope that it will be useful for our further understanding of how such dynamics affect the interplay between virus and host as well as for the discovery of novel therapeutic targets in the fight against HIV.
Hiv 1 Latency
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Author : Guido Silvestri
language : en
Publisher: Springer
Release Date : 2018-10-11
Hiv 1 Latency written by Guido Silvestri and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-11 with Medical categories.
This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.
Cd4 T Cells In Hiv A Friend Or Foe
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Author : Sunil Kannanganat Sidharthan
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-26
Cd4 T Cells In Hiv A Friend Or Foe written by Sunil Kannanganat Sidharthan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-26 with Medical categories.
Models Of Protection Against Hiv Siv
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Author : Gianfranco Pancino
language : en
Publisher: Academic Press
Release Date : 2011-12-02
Models Of Protection Against Hiv Siv written by Gianfranco Pancino and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-02 with Medical categories.
A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field
Aids Pathogenesis
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Author : H. Schuitemaker
language : en
Publisher: Springer Science & Business Media
Release Date : 2000-03-31
Aids Pathogenesis written by H. Schuitemaker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-03-31 with Medical categories.
Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS). The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection.
Disease Control Priorities Third Edition Volume 6
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Author : King K. Holmes
language : en
Publisher: World Bank Publications
Release Date : 2017-11-06
Disease Control Priorities Third Edition Volume 6 written by King K. Holmes and has been published by World Bank Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-06 with Medical categories.
Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Exploring Novel Approaches To Eliminate Hiv Reservoirs To Achieve A Cure For Hiv
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Author : Renee Marije Van Der Sluis
language : en
Publisher: Frontiers Media SA
Release Date : 2021-04-07
Exploring Novel Approaches To Eliminate Hiv Reservoirs To Achieve A Cure For Hiv written by Renee Marije Van Der Sluis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-07 with Science categories.
Immunopathogenesis Of Hiv Infection
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Author : Anthony S. Fauci
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immunopathogenesis Of Hiv Infection written by Anthony S. Fauci and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies.
Follicular Helper T Cells In Immunity And Autoimmunity
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Author : Georgia Fousteri
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-09
Follicular Helper T Cells In Immunity And Autoimmunity written by Georgia Fousteri and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-09 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Encyclopedia Of Aids
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Author : Thomas J. Hope
language : en
Publisher:
Release Date :
Encyclopedia Of Aids written by Thomas J. Hope and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with AIDS (Disease) categories.