Lymphocyte Development
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Lymphocyte Development
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Author : Shiv Pillai
language : en
Publisher: Springer Science & Business Media
Release Date : 2000-08-25
Lymphocyte Development written by Shiv Pillai and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-08-25 with Science categories.
"Lymphocyte Development" presents an extremely up-to-date account of molecular processes involved in the development of lymphocytes. This well written book is based on a graduate course taught by the author. Topics include the selection processes involved in lymphocyte maturation, immune receptor gene rearrangement, signaling pathways involved in cell cycle progression and apoptosis, and the transcriptional regulation of lymphoid ontogeny. The book also covers T cell development and differentiation of helper and cytotoxic T cells as well as the development of Natural Killer lymphocytes. The book finishes with an account of the molecular basis of immunodeficiency syndromes. It will interest researchers in immunology and it will be useful as a supplementary text for a graduate level immunology course.
Molecular Analysis Of B Lymphocyte Development And Activation
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Author : Harinder Singh
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-03-30
Molecular Analysis Of B Lymphocyte Development And Activation written by Harinder Singh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-30 with Medical categories.
The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.
Signal Transduction And The Coordination Of B Lymphocyte Development And Function I
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Author : Louis B. Justement
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Signal Transduction And The Coordination Of B Lymphocyte Development And Function I written by Louis B. Justement and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep ertoire of B cells that has the ability to recognize an almost un limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au toreactive B cells to exist in the periphery where they may com plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re straints that effectively attenuate their ability to respond to self antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.
Molecular Mechanisms Regulating Cytotoxic Lymphocyte Development And Function And Their Associations To Human Diseases
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Author : Konrad Krzewski
language : en
Publisher: Frontiers Media SA
Release Date : 2015-04-22
Molecular Mechanisms Regulating Cytotoxic Lymphocyte Development And Function And Their Associations To Human Diseases written by Konrad Krzewski and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-22 with Cell-mediated cytotoxicity categories.
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Development Of The Gastrointestinal Tract
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Author : Ian R. Sanderson
language : en
Publisher: PMPH-USA
Release Date : 2000
Development Of The Gastrointestinal Tract written by Ian R. Sanderson and has been published by PMPH-USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.
The authors chronicle the development of the gastrointestinal system b eginning with the embryology of the gastrointestinal tract through dev elopment of cells to hormones and enzymes. Each section provides detai led explanation of that stage of development so residents and clinicia ns can better understand the interrelationships of each structure. Spe cial attention is given to the latest cellular information and gene pr omoters in the regulation of intestinal development. Coverage of defec ts due to trauma and infections is also included.
Molecular Biology Of B Cell And T Cell Development
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Author : John G. Monroe
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Molecular Biology Of B Cell And T Cell Development written by John G. Monroe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Science categories.
Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.
Epigenetic Regulation Of Lymphocyte Development
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Author : Cornelis Murre
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-13
Epigenetic Regulation Of Lymphocyte Development written by Cornelis Murre and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-13 with Medical categories.
The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.
Abl Family Kinases In Development And Disease
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Author : Anthony Koleske
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-05-08
Abl Family Kinases In Development And Disease written by Anthony Koleske and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-08 with Science categories.
Abl Family Kinases in Development and Disease provides an overview of the functions of Abl family kinases in Development and Disease. This new title discusses the biochemical, genetic, and cell biological data that elucidate the cellular roles for these kinases in these processes.
Cellular And Molecular Immunology First South Asia Edition E Book
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Author : Abul K. Abbas
language : en
Publisher: Elsevier Health Sciences
Release Date : 2017-08-02
Cellular And Molecular Immunology First South Asia Edition E Book written by Abul K. Abbas and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-02 with Medical categories.
The top required and recommended immunology text worldwide, Cellular and Molecular Immunology by Drs. Abul K. Abbas, Andrew H. H. Lichtman, and Shiv Pillai, is a clear, well-written, and superbly illustrated introduction to the field. The First South Asia Edition retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area. - Highlights the implications of immunologic science for the management of human disease, emphasizing clinical relevance throughout. - Provides a highly visual, full-color description of the key immunologic and molecular processes with a fully updated, comprehensive, and consistent art program. - Helps readers grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions. - Includes summary boxes that assist with rapid review and mastery of key material.
Cellular And Molecular Immunology
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Author : Abul K. Abbas
language : en
Publisher: Elsevier Health Sciences
Release Date : 2017-03-10
Cellular And Molecular Immunology written by Abul K. Abbas and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-10 with Medical categories.
The top required and recommended immunology text worldwide, Cellular and Molecular Immunology by Drs. Abul K. Abbas, Andrew H. H. Lichtman, and Shiv Pillai, is a clear, well-written, and superbly illustrated introduction to the field. The 9th Edition retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area. - Highlights the implications of immunologic science for the management of human disease, emphasizing clinical relevance throughout. - Provides a highly visual, full-color description of the key immunologic and molecular processes with a fully updated, comprehensive, and consistent art program. - Helps readers grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions. - Includes summary boxes that assist with rapid review and mastery of key material. - Features updates from cover to cover, including tumor immunity (tumor antigens, cancer immunotherapy), immune checkpoints, cytosolic sensors for DNA, non-canonical inflammasomes, prionization as a signaling mechanism, monogenic defects in immunity, and more.