Mammalian Cell Derived Recombinant Human Growth Hormone
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Mammalian Cell Derived Recombinant Human Growth Hormone
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Author :
language : en
Publisher:
Release Date : 1992
Mammalian Cell Derived Recombinant Human Growth Hormone written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with categories.
Mammalian Cell Derived Recombinant Human Growth Hormone
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Author : N. Stahnke
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1992-01-01
Mammalian Cell Derived Recombinant Human Growth Hormone written by N. Stahnke and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-01-01 with Medical categories.
Mammalian Cell Derived Recombinanat Human Growth Hormone
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Author :
language : en
Publisher:
Release Date : 1992
Mammalian Cell Derived Recombinanat Human Growth Hormone written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Hormones categories.
Cell Culture Engineering
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Author : Wei-Shu Hu
language : en
Publisher: Springer
Release Date : 2006-08-16
Cell Culture Engineering written by Wei-Shu Hu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-16 with Science categories.
Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the ?rst generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the ?rst p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modi?cations on proteins could only be ef?ciently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein therapeutics, chie?y antibodies. In fact, it has been nearly a decade since the market value of mammalian-cell-derived protein therapeutics surpassed that of those produced from E. coli. A common characteristic of recent antibody products is the relatively large dose required for effective therapy, demanding larger quantities for the treatment of a given disease. This, coupled with the broadening repertoire of protein drugs, has rapidly expanded the quantity needed for clinical applications. The increasing demand for protein therapeutics has not been met exclusively by construction of new manufacturing plants and increasing total volume capacity. More - portantly the productivity of cell culture processes has been driven upward by an order of magnitude in the past decade.
Cell Culture Engineering
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Author : Wei-Shu Hu
language : en
Publisher: Springer
Release Date : 2006-08-23
Cell Culture Engineering written by Wei-Shu Hu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-23 with Science categories.
Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the ho- zon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the ?rst generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the ?rst p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modi?cations on proteins could only be ef?ciently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein therapeutics, chie?y antibodies. In fact, it has been nearly a decade since the market value of mammalian-cell-derived protein therapeutics surpassed that of those produced from E. coli. A common characteristic of recent antibody products is the relatively large dose required for effective therapy, demanding larger quantities for the treatment of a given disease. This, coupled with the broadening repertoire of protein drugs, has rapidly expanded the quantity needed for clinical applications. The increasing demand for protein therapeutics has not been met exclusively by construction of new manufacturing plants and increasing total volume capacity. More - portantly the productivity of cell culture processes has been driven upward by an order of magnitude in the past decade.
Cell Line Development
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Author : Mohamed Al-Rubeai
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-08-11
Cell Line Development written by Mohamed Al-Rubeai and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-11 with Medical categories.
Mammalian cell lines command an effective monopoly for the production of therapeutic proteins that require post-translational modifications. This unique advantage outweighs the costs associated with mammalian cell culture, which are far grater in terms of development time and manufacturing when compared to microbial culture. The development of cell lines has undergone several advances over the years, essentially to meet the requirement to cut the time and costs associated with using such a complex hosts as production platforms. This book provides a comprehensive guide to the methodology involved in the development of cell lines and the cell engineering approach that can be employed to enhance productivity, improve cell function, glycosylation and secretion and control apoptosis. It presents an overall picture of the current topics central to expression engineering including such topics as epigenetics and the use of technologies to overcome positional dependent inactivation, the use of promoter and enhancer sequences for expression of various transgenes, site directed engineering of defined chromosomal sites, and examination of the role of eukaryotic nucleus as the controller of expression of genes that are introduced for production of a desired product. It includes a review of selection methods for high producers and an application developed by a major biopharmaceutical industry to expedite the cell line development process. The potential of cell engineering approch to enhance cell lines through the manipulation of single genes that play important roles in key metabolic and regulatory pathways is also explored throughout.
Basic And Applied Aspects Of Biotechnology
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Author : Varsha Gupta
language : en
Publisher: Springer
Release Date : 2016-10-22
Basic And Applied Aspects Of Biotechnology written by Varsha Gupta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-22 with Technology & Engineering categories.
This book explores the journey of biotechnology, searching for new avenues and noting the impressive accomplishments to date. It has harmonious blend of facts, applications and new ideas. Fast-paced biotechnologies are broadly applied and are being continuously explored in areas like the environmental, industrial, agricultural and medical sciences. The sequencing of the human genome has opened new therapeutic opportunities and enriched the field of medical biotechnology while analysis of biomolecules using proteomics and microarray technologies along with the simultaneous discovery and development of new modes of detection are paving the way for ever-faster and more reliable diagnostic methods. Life-saving bio-pharmaceuticals are being churned out at an amazing rate, and the unraveling of biological processes has facilitated drug designing and discovery processes. Advances in regenerative medical technologies (stem cell therapy, tissue engineering, and gene therapy) look extremely promising, transcending the limitations of all existing fields and opening new dimensions for characterizing and combating diseases.
Growth And Lactogenic Hormones
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Author : L. Matera
language : en
Publisher: Gulf Professional Publishing
Release Date : 2002-04-18
Growth And Lactogenic Hormones written by L. Matera and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-18 with Medical categories.
For more than seventy years evidence has accumulated documenting the existence of a bi-directional communication network between growth hormone and the immune system. In the past twenty years there has been a tremendous proliferation of information detailing the workings of the growth hormone and insulin-like growth factor axis. A multitude of growth factors and binding proteins have been identified. More and more evidence supporting the important role of the growth hormone IGF network in the well functioning of the normal immune system has been documented. Clearly the challenge today is not to prove, but to understand, the neuroimmune regulatory role of GLH in its entire complexity. The ultimate goal of this volume and of all the other volumes of this series is to promote the understanding of the science and to ease human suffering.
Safety Of Biological Products Prepared From Mammalian Cell Culture
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Author : Fred Brown
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1998
Safety Of Biological Products Prepared From Mammalian Cell Culture written by Fred Brown and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
This volume reflects the proceedings of the WHO Consultation on the Safety of Biological Products Prepared from Mammalian Cell Substrates, and forms the basis upon which the revised WHO requirements were formulated and accepted by the 1996 Expert Committee on Biological Standardization (ECBS). Primary cells, diploid cells, and continuous cell lines (CCLs) are considered both in terms of potential risks and as appropriate methods to reduce and control those risks during the manufacturing process. Also discussed is the past clinical experience with products derived from these three types of cell substrates. Bringing together contributions by international experts in the field, this volume is important reading for cell and molecular biologists, and all those concerned with the development and manufacture of biological products.
Large Scale Mammalian Cell Culture Technology
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Author : Lubiniecki
language : en
Publisher: Routledge
Release Date : 2018-05-02
Large Scale Mammalian Cell Culture Technology written by Lubiniecki and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-02 with Medical categories.
An interdisciplinary approach, integrating biochemistry, biology, genetics, and engineering for the effective production of protein pharmaceuticals. The volume offers a biological perspective of large-scale animal cell culture and examines diverse processing strategies, process management, regulator