Marine Compounds And Cancer
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Marine Compounds And Cancer
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Author : Friedemann Honecker
language : en
Publisher: MDPI
Release Date : 2018-10-02
Marine Compounds And Cancer written by Friedemann Honecker and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-02 with categories.
This book is a printed edition of the Special Issue "Marine Compounds and Cancer" that was published in Marine Drugs
Marine Compounds And Cancer
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Author : Friedemann Honecker
language : en
Publisher: Mdpi AG
Release Date : 2021-06-11
Marine Compounds And Cancer written by Friedemann Honecker and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-11 with Science categories.
The very first marine-derived anticancer drug, Cytarabine (aka Ara-C, Cytosar-U(R)), was approved by the FDA in 1969 for the treatment of leukemia. At the beginning of 2021, the list of approved marine-derived anticancer drugs consists of nine substances, five of which received approval within the last two years, demonstrating the rapid evolution of the field. The current book is a collection of scientific articles related to the exponentially growing field of anticancer marine compounds. These articles cover the whole field, from agents with cancer-preventive activity, to novel and previously characterized compounds with anticancer activity, both in vitro and in vivo, as well as the latest status of compounds under clinical development.
Marine Compounds And Cancer
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Author :
language : en
Publisher: Mdpi AG
Release Date : 2015-11-23
Marine Compounds And Cancer written by and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-23 with Health & Fitness categories.
This book is based on a Special Issue called "Marine Compounds and Cancer" (http: //www.mdpi.com/journal/marinedrugs/special_issues/marine-compounds-cancer) of the open access journal, Marine Drugs (ISSN 1660-3397), which was running for two years (2013-2015). It comprises 39 articles in total, a quarter of which are reviews, summarizing the current state of the art in different topics of marineanti-cancer agents. It covers the full scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-canceractivity, both in vitro and in vivo, and the latest status of clinical development of marine agents used in clinical trials.
Marine Compounds And Cancer 2017
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Author : Friedemann Honecker
language : en
Publisher:
Release Date : 2018
Marine Compounds And Cancer 2017 written by Friedemann Honecker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Marine Compounds and Cancer 2017.
Marine Natural Products As Anticancer Agents
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Author : Celso Alves
language : en
Publisher: Mdpi AG
Release Date : 2021-11-12
Marine Natural Products As Anticancer Agents written by Celso Alves and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-12 with Medical categories.
Cancer remains one of the most significant threats to human health and one of the deadliest diseases worldwide, making it crucial to develop new drugs. Over the last few decades, natural products have become one of the key drivers in the development of innovative cancer treatments. Despite drug development from terrestrial resources, the marine environment only recently emerged as a prolific source of unparalleled structurally active metabolites. Due to their excellent scaffold diversity, structural complexity, and ability to act on multiple cell signaling networks involved in carcinogenesis, marine natural products (MNPs) are ideal candidates to inspire the development of novel anticancer medicines. This book gathers nine publications of the Special Issue "Marine Natural Products as Anticancer Agents," providing an excellent overview of the chemical richness offered by marine organisms, such as sponges, myxobacteria, fungi, and soft corals. MNPs or derived products belong to distinct chemical classes, including terpenoids, alkaloids, cyclodepsipeptides, polyketides, and hydroxyphenylacetic acid derivatives. These compounds modulate cancer cell mechanisms in in vitro and in vivo models, exhibiting high specificity and great affinity to interact with biological targets linked to specific intracellular signaling pathways, including mitochondrial dysfunction, autophagy, endoplasmic reticulum stress induction, apoptosis, inflammation, migration, and invasion. This volume provides an exciting overview of marine natural products as potential therapeutic agents for cancer treatment.
Handbook Of Anticancer Drugs From Marine Origin
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Author : Se-Kwon Kim
language : en
Publisher: Springer
Release Date : 2014-11-27
Handbook Of Anticancer Drugs From Marine Origin written by Se-Kwon Kim and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-27 with Science categories.
This timely desk reference focuses on marine-derived bioactive substances which have biological, medical and industrial applications. The medicinal value of these marine natural products are assessed and discussed. Their function as a new and important resource in novel, anticancer drug discovery research is also presented in international contributions from several research groups. For example, the potential role of Spongistatin, Apratoxin A, Eribulin mesylate, phlorotannins, fucoidan, as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae, bacteria, fungus, sponges, seaweeds and other marine animals and plants are illustrated via several mechanisms. In addition, this handbook lists various compounds that are active candidates in chemoprevention and their target actions. The handbook also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.
Marine Natural Products As Anticancer Agents 2 0
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Author : Celso Alves
language : en
Publisher: Mdpi AG
Release Date : 2023-06-12
Marine Natural Products As Anticancer Agents 2 0 written by Celso Alves and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-12 with categories.
Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, "Marine Natural Products as Anticancer Agents 2.0", gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
Official Gazette Of The United States Patent And Trademark Office
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Author :
language : en
Publisher:
Release Date : 1993
Official Gazette Of The United States Patent And Trademark Office written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Trademarks categories.
Studies In Natural Products Chemistry
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Author : Ajai Prakash Gupta
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-06-25
Studies In Natural Products Chemistry written by Ajai Prakash Gupta and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-25 with Science categories.
Cancer is a dreadful human disease, increasing with changing lifestyle, nutrition, and global warming. Its treatments do not have potent medicine as the currently available drugs results in severe side effects. Past activities in this area focused on the natural products derived from medicinal plants. According to the WHO, 80% of the world’s population primarily those from developing countries rely on plant-derived medicines for the health care. Over the past few decades, significant efforts have been made, jointly by pharmaceutical and academic institutions, to isolate and identify new marine-derived natural products. With the advancement of technology and methodology in this area, numerous new compounds have been isolated and several novel anticancer compounds are under clinical investigations. The ocean biomass, covering two-third of the earth, with huge unexplored natural product offers enormous scope and presents an effective alternative in natural product drug discovery. The uniqueness in oceanic mega-diversity is due to spatial as well as temporal competition along with unique habitat with extreme pressure, temperature, and saline conditions. As a result of this, marine organisms have adapted and evolved themselves successfully since centuries in these conditions by producing molecules which are unique in structures, biosynthesis, and function. This “chemical adaptations” is an excellent source of novel chemical entities which is absent in land-based organisms. The past decade has seen more than 10,000 compounds isolated from marine sources which have dramatically increased the number of preclinical anticancers drug under evaluation, and over 300 patents on bioactive natural products from marine sources were granted during this tenure. Efforts, in this direction, became more serious and focused with National Cancer Institute, USA taking a lead role. By collaborative interactions between pharmaceutical companies and research organization, numerous drug-like molecules with several of them having clinical and preclinical potential were discovered. Ecteinascidin-743/ET-743 from Caribbean tunicate and Didemnin and Aplidine from Aplidium albicans are some of the successful examples. Sterols and dietary fibers from seaweeds also hold immense potential. However, investigation of the marine floras chemical entities as drug-like molecule is still in its embryonic stage. The present chapter showcases the past research and reviews the baseline data for promoting further research in this field.
Trabectedin Lurbinectedin And Other Marine Derived Anticancer Alkaloids On Solid Cancer Mechanisms Of Action Clinical Impact And Future Perspectives
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Author : Alberto Zambelli
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-02
Trabectedin Lurbinectedin And Other Marine Derived Anticancer Alkaloids On Solid Cancer Mechanisms Of Action Clinical Impact And Future Perspectives written by Alberto Zambelli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-02 with Medical categories.
