Mass Spectrometry In Biomolecular Sciences


Mass Spectrometry In Biomolecular Sciences
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Mass Spectrometry In Biomolecular Sciences


Mass Spectrometry In Biomolecular Sciences
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Author : Richard M. Caprioli
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Mass Spectrometry In Biomolecular Sciences written by Richard M. Caprioli and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.


Mass Spectrometry in the Biological Sciences covers the most recent technological and applied developments in the area, including both ionization techniques and ion analysis. It introduces and reviews some of the newer ionization methods, describes the major instrumentation involved in mass analysis, and presents the scope of the technology in biology, medicine, and environmental science. Specific examples are given for a number of topics. It also deals with recent achievements in the on-line combination of separation techniques such as gas chromatography, liquid chromatography, and supercritical fluid technology.



Selected Topics In Mass Spectrometry In The Biomolecular Sciences


Selected Topics In Mass Spectrometry In The Biomolecular Sciences
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Author : Richard M. Caprioli
language : en
Publisher: Springer
Release Date : 2011-10-04

Selected Topics In Mass Spectrometry In The Biomolecular Sciences written by Richard M. Caprioli and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-04 with Science categories.


Many fundamental aspects of the methods used in mass spectrometry are here presented by outstanding scientists, with reference to very recent developments. The principles and applications of electrospray, ion spray and MALDI ionization technique are presented, together with optimised GC/MS interfacing systems and tools for quantitative analysis. A comprehensive treatment of modern instrumentation for mass analysis and detection is also included. The major part of the book deals with bioanalytical applications to peptides, proteins, oligonucleotides, polysaccharides, lipids and plant metabolites. Several papers are devoted to the evaluation of adduct formation between DNA and carcinogens. Environmental applications are also included, with examples of some specific cases. Fundamentals and applications are treated with the same degree of depth: the first two parts of the book therefore provide a basis for the understanding of the biomolecular applications section. Audience: Ideal for advanced graduate students of chemistry who have learned some basic mass spectrometry. Also useful for Ph.D. students in chemistry, biology and medicine. Of value to researchers in academic and industrial laboratories.



Clinical Applications Of Mass Spectrometry In Biomolecular Analysis


Clinical Applications Of Mass Spectrometry In Biomolecular Analysis
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Author : Uttam Garg
language : en
Publisher: Springer Nature
Release Date : 2022-09-20

Clinical Applications Of Mass Spectrometry In Biomolecular Analysis written by Uttam Garg and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-20 with Science categories.


This updated volume provides stepwise instructions for the analysis of numerous clinically important analytes by mass spectrometry. Mass spectrometry offers clinical laboratory scientists a number of advantages including increased sensitivity and specificity, multiple component analysis, and limited need for specialized reagents. These techniques are essential in laboratory fields including endocrinology, biochemical genetics, drug analysis, proteomics, and pathogen identification. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Clinical Applications of Mass Spectrometry in Biomolecular Analysis: Methods and Protocols, Second Edition is an ideal resource for clinical laboratory scientists who are already using or thinking of bringing mass spectrometry to their laboratories.



Mass Spectrometry In The Biological Sciences A Tutorial


Mass Spectrometry In The Biological Sciences A Tutorial
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Author : M.L Gross
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Mass Spectrometry In The Biological Sciences A Tutorial written by M.L Gross and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.


The developments in mass spectrometry over the past fifteen years have been impressive in their implications in bioanalytical chemistry. The achievements begin with the inventions of Cf-252 Plasma Desorption Mass Spectrometry by Macfarlane and Fourier Transform Mass Spectrometry by Comisarow and Marshall in the mid 1970s. The former showed the feasibility of producing large gas-phase ions from large biomolecules whereas the latter enhanced the capabilities for ion trapping especially in analytical mass spectrometry. A major achievement was the development by Barber of Fast Atom Bombardment (FAB) mass spectrometry, an advance that heralded a new era in biological mass spectrometry. Contemporary and routine instruments such as magnetic sectors and quadrupoles were rapidly adapted to F AB, and nearly the entire universe of small molecules became amenable to study by mass spectrometry. The introduction of FAB also paved the way for improvement of instrument capability. For example, the upper mass limit of magnet sector mass spectrometers was increased by nearly an order of magnitude by the instrument manufacturers. Furthermore, the technique of tandem mass spectrometry (MS/MS) was given new meaning because important structural information for biomolecules could now be produced for ions introduced by FAB into the tandem instrument. The evolution of MS/MS continues today with the development of ion traps, time-of-flight, and sector instruments equipped with array detection.



Mass Spectrometry In The Biological Sciences


Mass Spectrometry In The Biological Sciences
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Author : A. L. Burlingame
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Mass Spectrometry In The Biological Sciences written by A. L. Burlingame and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.


Leading practitioners describe in detail advanced methods of mass spectrometry used in structural characterization of biomacromolecules of both natural and recombinant origin. They demonstrate by example how these methodologies can solve a wide array of real-world problems in protein biochemistry, immunology, and glycobiology, as well as for human bacterial pathogens, lipids, and nucleic acids. The book offers a unique opportunity to learn these techniques that are revolutionizing the field. Its authoritative assessment in the context of how to solve important and challenging problems in bioscience and medicine ensures a competitive advantage for today's researchers.



Introduction To Mass Spectrometry Of Biomolecules


Introduction To Mass Spectrometry Of Biomolecules
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Author : Marko Jovanović
language : en
Publisher: Nova Science Publishers
Release Date : 2016

Introduction To Mass Spectrometry Of Biomolecules written by Marko Jovanović and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with SCIENCE categories.


The theses, lectures and solved problems within this book give an introduction to principles of mass spectrometry related to the analysis of biomolecules. The book focuses on MS and MS/MS analysis of peptides, oligosaccharides, lipids, glycoconjugates and polyphenols. The basic properties of modern MS ionization techniques and mass analyzers are presented, as well as appropriate MS methods for each class of biomolecules in modern biomedical scientific research. The biggest part of this book is focused on MS/MS analysis of biomolecules: how the MS and MS/MS data are generated, what are the basic strategies for their structural analysis, as well as how to interpret the respective MS and MS/MS data. This book also covers principles and examples of advanced MS/MS analyses, serving as a platform towards an intermediate level of understanding scientific research carried out in the field of structural MS analysis of biomolecules. It is the author's hope that the reader will be able to understand principles of MS analyses related to their scientific and/or analytical interest, as well as design/help to propose MS and MS/MS experiments, as well as interpret the obtained data. This book is primarily written for students with basic knowledge of general, organic and analytical chemistry, and who are interested in applying MS-based methodologies in biomedical research fields, as well as interested in pursuing a career in mass spectrometry. Therefore it is best suited for senior undergraduate students and first/second year Ph.D. students. However, since MS instrumentation is rapidly adopted on all levels of scientific as well as analytical laboratories, the book should prove useful to scientists -- as well as analysts -- interested in applying MS in their upgraded laboratories. The author hopes that the reader, after studying the content presented, will be able to read primary scientific literature containing MS data to learn more about specific topics of interest, as well as be more capable of choosing a MS-related career path. For senior scientists, this book can offer some basic insights related to choosing a post-doc laboratory, or simply easier and more fruitful cooperation with mass spectrometrists.



Recent Developments In Biomolecular Nmr


Recent Developments In Biomolecular Nmr
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Author : Marius Clore
language : en
Publisher: Royal Society of Chemistry
Release Date : 2012-08-21

Recent Developments In Biomolecular Nmr written by Marius Clore and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-21 with Science categories.


NMR spectroscopy is widely used in biomolecular science particularly for structure determination of proteins, nucleic acids and carbohydrates. Much of the innovation within NMR spectroscopy has been within the field of protein NMR spectroscopy, an important technique in structural biology. Filling a gap in the literature, this book draws together experts in the field to discuss the real advances in NMR methods that have occurred or have an impact on the biomolecular field in the last few years. The coverage includes recent developments in using NMR for determination of protein structures, membrane proteins, the dynamics of RNA and advances in NMR in drug discovery. Edited by leading biological NMR spectroscopists, the book is essential reference for researchers in industry and academia interested in or joining this bioanalytical field.



Analyzing Biomolecular Interactions By Mass Spectrometry


Analyzing Biomolecular Interactions By Mass Spectrometry
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Author : Jeroen Kool
language : en
Publisher: John Wiley & Sons
Release Date : 2015-02-09

Analyzing Biomolecular Interactions By Mass Spectrometry written by Jeroen Kool and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-09 with Science categories.


This monograph reviews all relevant technologies based on mass spectrometry that are used to study or screen biological interactions in general. Arranged in three parts, the text begins by reviewing techniques nowadays almost considered classical, such as affinity chromatography and ultrafiltration, as well as the latest techniques. The second part focusses on all MS-based methods for the study of interactions of proteins with all classes of biomolecules. Besides pull down-based approaches, this section also emphasizes the use of ion mobility MS, capture-compound approaches, chemical proteomics and interactomics. The third and final part discusses other important technologies frequently employed in interaction studies, such as biosensors and microarrays. For pharmaceutical, analytical, protein, environmental and biochemists, as well as those working in pharmaceutical and analytical laboratories.



Mass Spectrometry For Biotechnology


Mass Spectrometry For Biotechnology
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Author : Gary Siuzdak
language : en
Publisher: Elsevier
Release Date : 1996-02-12

Mass Spectrometry For Biotechnology written by Gary Siuzdak and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-02-12 with Science categories.


If you investigate biological systems and might use mass spectrometry in your research but need to know more about it, this book is for you. It introduces the fundamental concepts of mass spectrometry and how mass spectrometers work. It also presents recent advancements particularly interesting to bio-researchers in an easy-to-understand manner that does not require extensive background in chemistry, math, or physics. Glossary of basic terms Abundant illustrations Examples of applications Practical tips on using mass spectrometric techniques Useful for peptide, protein, oligonucleotide, and carbohydrate analysis Simplified description of mass spectrometry including: Matrix-Assisted Laser Desorption/Ionization (MALDI) Electrospray Ionization (ESI) Fast Atom/Ion Bombardment (FAB)



Mass Spectrometry Of Biological Materials Second Edition


Mass Spectrometry Of Biological Materials Second Edition
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Author : Barbara S. Larsen
language : en
Publisher: CRC Press
Release Date : 1998-03-02

Mass Spectrometry Of Biological Materials Second Edition written by Barbara S. Larsen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-03-02 with Science categories.


Second Edition provides up-to-the-minute discussions on the application of mass spectrometry to the biological sciences. Shows how and why experiments are performed and furnishes details to facilitate duplication of results.