Mass Spectrometry In Drug Metabolism
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Using Mass Spectrometry For Drug Metabolism Studies Second Edition
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Author : Walter A. Korfmacher
language : en
Publisher: CRC Press
Release Date : 2009-11-03
Using Mass Spectrometry For Drug Metabolism Studies Second Edition written by Walter A. Korfmacher and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-03 with Science categories.
The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the field, the emergence of cutting-edge approaches, and ways to meet steadily increasing vendor demands. Written by international scientists who are experts in their respective disciplines, this state-of-the-art reference effectively encapsulates current mass spectrometry best practices. The stand-alone chapters cover various topics – from metabolite identification to fast chromatography with UPLC – and in a style that is understandable to experts and field newcomers alike. The second edition of this bestseller includes coverage of new instrumentation and software as well as a wealth of updated information on the latest findings surrounding biomarkers and metabolomics and new chapters on both UPLC and DESI/DART. With more than 180 illustrations and an eight-page color insert, this valuable reference explores multiple modern mass spectrometry techniques and strategies. It includes an excellent overview of the entire drug discovery process plus the latest developments on how mass spectrometry is used to support this endeavor.
Mass Spectrometry In Drug Metabolism
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Author : Frigerio
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mass Spectrometry In Drug Metabolism written by Frigerio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
When a dose of drug is administered, three main phases of drug action may be distingushed. In the "pharmaceutical" phase the dosage form disintegrates, the active substance dissolves and becomes available for absorption. The second phase ("pharmaco kinetic" phase) includes absorption, distribution, metabolism, and excretion. That fraction of the dose which finally reaches the circulation after absorption will be available for biological action in the third, or "pharmacodynamic" phase when the drug reaches the target tissues and a drug-receptor interaction takes place. The objectives in studies of drug metabolism are: (a) to identify the pathways by which drugs are transformed in the body; (b) to ascertain quantitatively the importance of each pathway and intermediate; (c) to identify and quantify endogenous constituents influenced by the drug or its metabolites which may interfere with common metabolic processes. Since metabolites usually differ from their precursors by only a single chemical group, the resulting metabolic pathways generally consist of a series of closely related compounds. Mass spectrometry is uniquely suited for the analysis of drugs and metabolites for several reasons: only a minimal amount of sample preparation is needed, closely related compounds can be analyzed in a single step, structures can often be deduced directly from the mass spectra without the need for pure reference spectra, and constituents can be quantified with relative ease even when present in fractional nanogram quantity.
Mass Spectrometry In Drug Metabolism And Disposition
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Author : Mike S. Lee
language : en
Publisher: John Wiley & Sons
Release Date : 2011-03-16
Mass Spectrometry In Drug Metabolism And Disposition written by Mike S. Lee and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-16 with Science categories.
This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.
Mass Spectrometry In Drug Metabolism
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Author : Alberto Frigerio
language : en
Publisher:
Release Date : 1976
Mass Spectrometry In Drug Metabolism written by Alberto Frigerio and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Drug abuse categories.
Mass Spectrometry In Drug Metabolism And Pharmacokinetics
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Author : Ragu Ramanathan
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-20
Mass Spectrometry In Drug Metabolism And Pharmacokinetics written by Ragu Ramanathan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-20 with Science categories.
This timely reference discusses mass spectrometry in drug metabolism and pharmacokinetic studies. With contributions by professionals from the pharmaceutical industry, this book begins with a review of current mass spectrometry techniques and applications, followed by discussions of various methods for using MS in drug metabolism studies and pharmacokinetics. Highlighting the critical importance of ADME studies for understanding how a drug is absorbed, distributed, metabolized, and excreted by the body, the book s focuses on the use of LC/MS and MALDI-MS. This is a valuable reference for scientists in the pharmaceutical industry, medicine, academia, and even those working in homeland defense.
Mass Spectrometry In Drug Metabolism
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Author : 3Island Press
language : en
Publisher:
Release Date : 1977-03-01
Mass Spectrometry In Drug Metabolism written by 3Island Press and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977-03-01 with categories.
Using Mass Spectrometry For Drug Metabolism Studies Second Edition
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Author : Walter A. Korfmacher
language : en
Publisher: CRC Press
Release Date : 2009-11-03
Using Mass Spectrometry For Drug Metabolism Studies Second Edition written by Walter A. Korfmacher and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-03 with Science categories.
The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicinal chemists and mass spectrometry professionals up to speed with the rapid advances in the field, the emergence of cutting-edge approaches, and ways to meet steadily increasing vendor demands. Written by international scientists who are experts in their respective disciplines, this state-of-the-art reference effectively encapsulates current mass spectrometry best practices. The stand-alone chapters cover various topics – from metabolite identification to fast chromatography with UPLC – and in a style that is understandable to experts and field newcomers alike. The second edition of this bestseller includes coverage of new instrumentation and software as well as a wealth of updated information on the latest findings surrounding biomarkers and metabolomics and new chapters on both UPLC and DESI/DART. With more than 180 illustrations and an eight-page color insert, this valuable reference explores multiple modern mass spectrometry techniques and strategies. It includes an excellent overview of the entire drug discovery process plus the latest developments on how mass spectrometry is used to support this endeavor.
Mass Spectrometry In Drug Discovery
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Author : David T. Rossi
language : en
Publisher: CRC Press
Release Date : 2001-11-07
Mass Spectrometry In Drug Discovery written by David T. Rossi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-07 with Medical categories.
Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates. It provides time- and cost-efficient approaches for the generation and analysis of effective pharmaceuticals, covers advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing, and demonstrates the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents.
Identification And Quantification Of Drugs Metabolites And Metabolizing Enzymes By Lc Ms
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Author : Swapan Chowdhury
language : en
Publisher: Elsevier
Release Date : 2005-11-04
Identification And Quantification Of Drugs Metabolites And Metabolizing Enzymes By Lc Ms written by Swapan Chowdhury and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-04 with Science categories.
As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the gap in the lack of presently available literature by providing a critical review in the current use of liquid chromatography-mass spectrometry (LC-MS) in drug discovery and development. With chapters written by experts with a wide range of practical experience from the pharmaceutical industry, emphasis is placed on techniques and applications. The book also includes chapters on how to utilize LC-MS instrumentation for current drug metabolism problems. This book is intended for those beginning to use LC-MS for drug metabolism studies as well as for those considered advanced practitioners. * Introduces readers to the practical applications of modern liquid chromatography-mass spectrometry (LC-MS) in a wide range of drug metabolism studies· * Provides a comprehensive description of different forms of metabolites, with detailed discussion on the wide range of methodologies used to identify them * Highlights problems associated with drug quantification and offers practical solutions
Mass Spectrometry For Drug Discovery And Drug Development
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Author : Walter A. Korfmacher
language : en
Publisher: John Wiley & Sons
Release Date : 2012-12-12
Mass Spectrometry For Drug Discovery And Drug Development written by Walter A. Korfmacher and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-12 with Science categories.
Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics. Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: HPLC high-resolution mass spectrometry for quantitative assays Mass spectrometry for siRNA Quantitative analysis of peptides Mass spectrometry analysis of biological drugs Applications that support medicinal chemistry investigations Mass spectrometry imaging and profiling Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field. Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.